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Kaldyrkaeva O.S.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Arzamastsev E.V.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Terekhova O.A.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Afanasieva E.Yu.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Levitskaya E.L.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Kydryavtseva E.V.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Polyektova V.P.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Gaisinyuk T.V.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Borisova E.Ya.

MIREA — Russian Technological University

Borisova N.Yu.

MIREA — Russian Technological University

Asilova N.Yu.

MIREA — Russian Technological University

Zubin E.M.

MIREA — Russian Technological University

Krylov A.V.

MIREA — Russian Technological University

Antiarrhythmic properties and toxicological characteristics of N-(2-(2-(dialkylamino)ethoxy)ethyl)carboxamides

Authors:

Kaldyrkaeva O.S., Arzamastsev E.V., Terekhova O.A., Afanasieva E.Yu., Levitskaya E.L., Kydryavtseva E.V., Polyektova V.P., Gaisinyuk T.V., Borisova E.Ya., Borisova N.Yu., Asilova N.Yu., Zubin E.M., Krylov A.V.

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Journal: Russian Cardiology Bulletin. 2022;17(2): 47‑54

DOI: 10.17116/Cardiobulletin20221702147

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Table of contents

ANTIARRHYTHMIC PROPERTIES AND TOXICOLOGICAL CHARACTERISTICS OF N-(2-(2-(DIALKYLAMINO)ETHOXY)ETHYL)CARBOXAMIDES
ANTIARRHYTHMIC PROPERTIES AND TOXICOLOGICAL CHARACTERISTICS OF N-(2-(2-(DIALKYLAMINO)ETHOXY)ETHYL)CARBOXAMIDES

To cite this article:

Kaldyrkaeva OS, Arzamastsev EV, Terekhova OA, et al. . Antiarrhythmic properties and toxicological characteristics of N-(2-(2-(dialkylamino)ethoxy)ethyl)carboxamides. Russian Cardiology Bulletin. 2022;17(2):47‑54. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221702147

Подписка 2025-2 (Russian Cardiology Bulletin)
 
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Heart rhythm disturbances have a special place among cardiovascular diseases and often cause sudden death and various dangerous complications. Modern antiarrhythmic drugs belonging to different classes of chemical compounds often have trivial efficacy and pro-arrhythmic action that significantly limits their use in certain clinical cases. Screening of new original compounds of N-(2-(2-(dialkylamino)ethoxy)ethyl)carboxamide class and subsequent pharmacological and toxicological analysis allowed identifying the compounds with antiarrhythmic properties and high antiarrhythmic indices. These compounds have a great practical interest for synthesis of new drugs for prevention and treatment of cardiac arrhythmias.

Keywords:

aminoamides
arrhythmia
new drugs
antiarrhythmic drugs
antiarrhythmic index
toxicological studies
pharmacological studies

Authors:

Kaldyrkaeva O.S.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Arzamastsev E.V.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Terekhova O.A.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Afanasieva E.Yu.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Levitskaya E.L.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Kydryavtseva E.V.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Polyektova V.P.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Gaisinyuk T.V.

National Medical Research Centre of Cardiology named after academician E.I. Chazov

Borisova E.Ya.

MIREA — Russian Technological University

Borisova N.Yu.

MIREA — Russian Technological University

Asilova N.Yu.

MIREA — Russian Technological University

Zubin E.M.

MIREA — Russian Technological University

Krylov A.V.

MIREA — Russian Technological University

Received:

28.03.2022

Accepted:

14.04.2022

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