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Sidko A.R.

National Medical Research Center of Cardiology

Osmak G.Zh.

National Medical Research Center of Cardiology;
Pirogov Russian National Research Medical University

Titov B.V.

National Medical Research Center of Cardiology;
Pirogov Russian National Research Medical University

Sukhinina T.S.

National Medical Research Center of Cardiology

Favorova O.O.

Pirogov Russian National Research Medical University

Polymorphic variants of the PIK3CA, CDKN2B-AS1 and AGTR1 genes associated with age of myocardial infarction onset

Authors:

Sidko A.R., Osmak G.Zh., Titov B.V., Sukhinina T.S., Favorova O.O.

More about the authors

Journal: Russian Cardiology Bulletin. 2021;16(1): 43‑48

DOI: 10.17116/Cardiobulletin20211601143

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Table of contents

POLYMORPHIC VARIANTS OF THE PIK3CA, CDKN2B-AS1 AND AGTR1 GENES ASSOCIATED WITH AGE OF MYOCARDIAL INFARCTION ONSET
POLYMORPHIC VARIANTS OF THE PIK3CA, CDKN2B-AS1 AND AGTR1 GENES ASSOCIATED WITH AGE OF MYOCARDIAL INFARCTION ONSET

To cite this article:

Sidko AR, Osmak GZh, Titov BV, Sukhinina TS, Favorova OO. Polymorphic variants of the PIK3CA, CDKN2B-AS1 and AGTR1 genes associated with age of myocardial infarction onset. Russian Cardiology Bulletin. 2021;16(1):43‑48. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20211601143

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

We have previously reported age-dependent approach to assessing the risk of myocardial infarction (MI). This method was based on analysis of carriage of allelic variants of genes determining susceptibility to this polygenic disease.

OBJECTIVE

To assess the relationship of MI onset age and carriage of genetic variants PTEN (rs701848), AKT1 (rs2494731), TP53 (rs1042522), PIK3CA (rs6443624), VEGFA (rs3025039), CDKN2B-AS1 (rs518394 and rs564398), AGTR1 (rs5186) and MIR126 (rs4636297).

MATERIAL AND METHODS

Genotyping of DNA samples from the peripheral blood of 289 Russian patients with a known age of MI onset was carried out by using of real-time polymerase chain reaction. Survival curves for carriers of various genetic variants were analyzed using R and Python 3 languages.

RESULTS

We found a significant association of polymorphic variants C*rs5186 of the AGTR1 gene (HR=1.43, p=0.023), A*rs66443624 of the PIK3CA gene (HR=1.42, p=0.01), C*rs518394 of the CDKN2B-AS1 gene (HR=1.70, p=0.000038) with MI onset age. MI occurs 3—8 years earlier in carriers of these variants compared to carriers of alternative genotypes.

CONCLUSION

These data may be used to improve the modern coronary risk assessment scales.

Keywords:

myocardial infarction
single nucleotide polymorphisms
age-related diseases
survival analysis

Authors:

Sidko A.R.

National Medical Research Center of Cardiology

Osmak G.Zh.

National Medical Research Center of Cardiology;
Pirogov Russian National Research Medical University

Titov B.V.

National Medical Research Center of Cardiology;
Pirogov Russian National Research Medical University

Sukhinina T.S.

National Medical Research Center of Cardiology

Favorova O.O.

Pirogov Russian National Research Medical University

Received:

20.01.2021

Accepted:

14.02.2021

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