The association between rs699947 polymorphism of VEGF-A gene with the development of cardiovascular complications within 1 year after myocardial infarction with ST elevation. The results of a prospective study

Magamedkerimova F.A.; Ivantsov E.N.; Khasanov N.R.

doi:https://doi.org/10.17116/Cardiobulletin20191401154

Magamedkerimova F.A.

Department of introduction into internal medicine of Kazan State Medical University, Kazan, Russia

Ivantsov E.N.

Department of introduction into internal medicine of Kazan State Medical University, Kazan, Russia

Khasanov N.R.

Department of introduction into internal medicine of Kazan State Medical University, Kazan, Russia

The association between rs699947 polymorphism of VEGF-A gene with the development of cardiovascular complications within 1 year after myocardial infarction with ST elevation. The results of a prospective study

Authors:

Magamedkerimova F.A., Ivantsov E.N., Khasanov N.R.

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Journal: Russian Cardiology Bulletin. 2019;14(1): 54‑59

DOI: 10.17116/Cardiobulletin20191401154

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To cite this article:

Magamedkerimova FA, Ivantsov EN, Khasanov NR. The association between rs699947 polymorphism of VEGF-A gene with the development of cardiovascular complications within 1 year after myocardial infarction with ST elevation. The results of a prospective study. Russian Cardiology Bulletin. 2019;14(1):54‑59. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20191401154

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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Abstract:

This prospective study included 135 patients with STEMI hospitalized in the Emergency Cardiac Care Department at the Centre of Emergency Medicine, in Kazan. Patients were observed over the course of one year (average duration of follow-up: 340±7 days). Ischemic and haemorrhagic events occurring during the observation period were recorded. The aim of the study was to assess the contribution of rs699947 polymorphism in the VEGF-A gene to the development of various complications within 1 year in patients after ST-segment elevation myocardial infarction. During the study, 17 patients were lost to follow-up, with the final analysis comprising data from 118 patients. The AA genotype in the VEGF-A gene is associated with a significant increase in the risk of cardiovascular events in patients in the first year after STEMI. The presence of the AA genotype in the VEGF-A gene should be considered an important genetic risk factor for cardiovascular death, myocardial infarction, stroke (p=0.019; OR 5.35 [1.40—20.51]) and all-cause death (p=0.01; OR 6.77 [1.65—27.79]) in patients in the first year after STEMI.

Keywords:

rs699947

VEGF-A gene

ST-segment elevation myocardial infarction

cardiovascular events

Authors:

Magamedkerimova F.A.

Department of introduction into internal medicine of Kazan State Medical University, Kazan, Russia

Ivantsov E.N.

Department of introduction into internal medicine of Kazan State Medical University, Kazan, Russia

Khasanov N.R.

Department of introduction into internal medicine of Kazan State Medical University, Kazan, Russia

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References:

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