Predictive significance of hla-dq2.2 genotype for children with celiac disease

Shapovalova N.S.; Novikova V.P.; Revnova M.O.; Nasyrov R.A.; Lapin S.V.; Kholopova I.V.; Klikunova K.A.

doi:https://doi.org/10.17116/dokgastro201870416

Shapovalova N.S.

Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia

Novikova V.P.

Saint-Petersburg State Pediatric Medical University, Saint- Petersburg, Russia

Revnova M.O.

St. Petersburg State Pediatric Medical, Russia, 194044, St. Petersburg, St. Litovskaya 2

Nasyrov R.A.

St. Petersburg State Pediatric Medical, Russia, 194044, St. Petersburg, St. Litovskaya 2

Lapin S.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

ORCID: 0000-0002-4998-3699

Kholopova I.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

Klikunova K.A.

St. Petersburg State Pediatric Medical, Russia, 194044, St. Petersburg, St. Litovskaya 2

Predictive significance of hla-dq2.2 genotype for children with celiac disease

Authors:

Shapovalova N.S., Novikova V.P., Revnova M.O., Nasyrov R.A., Lapin S.V., Kholopova I.V., Klikunova K.A.

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Journal: Russian Journal of Evidence-Based Gastroenterology. 2018;7(4): 6‑11

DOI: 10.17116/dokgastro201870416

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To cite this article:

Shapovalova NS, Novikova VP, Revnova MO, Nasyrov RA, Lapin SV, Kholopova IV, Klikunova KA. Predictive significance of hla-dq2.2 genotype for children with celiac disease. Russian Journal of Evidence-Based Gastroenterology. 2018;7(4):6‑11. (In Russ.)
https://doi.org/10.17116/dokgastro201870416

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)

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Abstract:

Currently, there are attempts to reveal the correlation between genotype of patients with celiac disease (CD) and severity/course of disease. Aim — to analyze serological and morphological features of duodenal mucous membrane in CD children with DQ2.2 genotype. Material and methods. There were 47 children with CD diagnosed according to ESPHGAN criteria. In all children, antibodies to tissue transglutaminase-2 (TTG) and deamidated gliadin peptide were determined, morphometric study of duodenal mucous membrane specimens and genotyping were carried out. Children were divided into two groups depending on genotype: group I consisted of 18 children with DQ2.2 genotype, group II — 29 children with other genotypes. Results. Increased level of TTG antibodies was observed in all patients in group I. Moderate increase was noted in 55.6% of group I and in 27.6% of group II (p=0.07); significant elevation occurred in 44.4% of group I and in 3.4% of group II (p=0.001). In addition, duodenal mucous membrane atrophy Marsh 3b was more common in group I (27.8%) compared with group II (0%, p=0.006). Group I was characterized by more severe atrophic changes of duodenal mucous membrane. Conclusion. It is assumed that DQ2.2 genotype may be considered as a predictor of more severe serological (significant increase of TTG-2 antibodies) and morphological changes in children with CD.

Keywords:

celiac disease

HLA-DQ22

tissue transglutaminase

Authors:

Shapovalova N.S.

Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia

Novikova V.P.

Saint-Petersburg State Pediatric Medical University, Saint- Petersburg, Russia

Revnova M.O.

St. Petersburg State Pediatric Medical, Russia, 194044, St. Petersburg, St. Litovskaya 2

Nasyrov R.A.

St. Petersburg State Pediatric Medical, Russia, 194044, St. Petersburg, St. Litovskaya 2

Lapin S.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

ORCID: 0000-0002-4998-3699

Kholopova I.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

Klikunova K.A.

St. Petersburg State Pediatric Medical, Russia, 194044, St. Petersburg, St. Litovskaya 2

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References:

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