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Bykova V.P.

Otdel zabolevaniĭ ukha, laboratoriia patologicheskoĭ anatomii LOR-organov NKTs otorinolaringologii FMBA Rossii

Daĭkhes N.A.

Nauchno-klinicheskiĭ tsentr otorinolaringologii FMBA Rossii, Moskva

Platonova G.A.

Clinical Hospital, Moscow, Russia

Bakhtin A.A.

Research Clinical Centre for Otorhinolaryngology, Federal Biomedical Agency of the Russian Federation, Moscow, Russia

Kornienko R.A.

LOR-otdelenie Tsentral'nogo gospitalia GUVD, Moskva, Rossiia, 127299

Romanenko S.G.

Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii im. L.I. Sverzhevskogo Departamenta zdravookhraneniia Moskvy, Moskva, Rossiia, 117152

Nazhmudinov I.I.

Research and Clinical Department of the Diseases of Upper Respiratory Tracts, Research and Clinical Centre of Otorhinolaryngology, Russian Federal Medico-Biological Agency, Moscow, Russia

Tumor-like amyloidosis of the upper respiratory tract

Authors:

Bykova V.P., Daĭkhes N.A., Platonova G.A., Bakhtin A.A., Kornienko R.A., Romanenko S.G., Nazhmudinov I.I.

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Journal: Russian Journal of Archive of Pathology. 2019;81(5): 74‑79

DOI: 10.17116/patol20198105174

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To cite this article:

Bykova VP, Daĭkhes NA, Platonova GA, Bakhtin AA, Kornienko RA, Romanenko SG, Nazhmudinov II. Tumor-like amyloidosis of the upper respiratory tract. Russian Journal of Archive of Pathology. 2019;81(5):74‑79. (In Russ.)
https://doi.org/10.17116/patol20198105174

Подписка 2025 (Russian Journal of Archive of Pathology)
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The paper describes 11 cases of local tumor-like amyloidosis (LTA) of the upper respiratory tract, among which laryngeal amyloidosis was most common. The clinical diagnosis of suspected local amyloidosis was made in only two cases. The diagnosis of local amyloidosis was established at a morphological examination of a distant neoplasm, by using special Congo red staining followed by polarizing microscopy. Attention is drawn to the localization and sequence of amyloid deposition and morphological changes related to the age of patients and the duration of the disease. The paper discusses the nature of local amyloidosis as stromal vascular proteinosis with the deposition of AL amyloid (immunoglobulin light chain amyloid) that are formed apparently by local immunocytes of the mucosa-associated lymphoid tissue (MALT) system. It emphasizes the need for the clinical monitoring of patients with LTA to rule out systemic amyloidosis.

Keywords:

upper respiratory tract amyloidosis
systemic and local forms
morphological diagnosis in clinical diagnosis

Authors:

Bykova V.P.

Otdel zabolevaniĭ ukha, laboratoriia patologicheskoĭ anatomii LOR-organov NKTs otorinolaringologii FMBA Rossii

Daĭkhes N.A.

Nauchno-klinicheskiĭ tsentr otorinolaringologii FMBA Rossii, Moskva

Platonova G.A.

Clinical Hospital, Moscow, Russia

Bakhtin A.A.

Research Clinical Centre for Otorhinolaryngology, Federal Biomedical Agency of the Russian Federation, Moscow, Russia

Kornienko R.A.

LOR-otdelenie Tsentral'nogo gospitalia GUVD, Moskva, Rossiia, 127299

Romanenko S.G.

Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii im. L.I. Sverzhevskogo Departamenta zdravookhraneniia Moskvy, Moskva, Rossiia, 117152

Nazhmudinov I.I.

Research and Clinical Department of the Diseases of Upper Respiratory Tracts, Research and Clinical Centre of Otorhinolaryngology, Russian Federal Medico-Biological Agency, Moscow, Russia

List of references:

  1. Serov VV, Shamov IA. Amyloidosis (Amiloidoz). Moscow: Meditsina, 1977. (In Russ.)
  2. Saltykow BB, Warshavskii VA, Berestova AI, Litvitskii PF, Kogan EA. Dystrophy. In: Paltsev MA, Paukov VS, Ulumbekov EG, eds. Pathology. Textbook (Patologiya. Rukovodstvo). Moscow: GEOTAR-Media, 2002;27-33. (In Russ.)
  3. Naiki H, Okoshi T, Ozawa D, Yamaguchi I, Hasegawa K. Molecular pathogenesis of human amyloidosis: lesson from ß2-microglobulin-related amyloidosis. Pathol Int. 2016;66(4):193-201. https://doi.org/10.1111/pin.12394
  4. Thompson LD, Derringer GA, Wenig BM. Amyloidosis of the larynx: a clinicopathologic study of 11 cases. Mod Pathol. 2000;13(5):528-535. https://doi.org/10.1038/modpathol.3880092
  5. Daikhes NA, Bykova VP, Ponomarev AB, Davudov KhSh. Clinical pathology of the larynx (Klinicheskaya patologiya gortani). Moscow: MIA, 2009 (In Russ.)
  6. Thompson LD. Head and neck pathology. Goldblum JR, ed. Churchill Livingstone, Elsevier, 2006.
  7. Wenig BM, Childers ELB, Richardson VS, Seethala RR, Thompson LD. Non-neoplastic diseases of the head and neck. Atlas of nontumor pathology. King DW, ed. AFIP ARP Press, 2017. Received 19.12.18

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