The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Vasil'ev N.V.

FGBNU "Tomskiĭ NII onkologii", Tomsk, Rossiia, 634028

Lymph node metastasis of osteosarcomas

Authors:

Vasil'ev N.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2016;78(4): 58‑63

DOI: 10.17116/patol201678458-62

Read: 8678 times

Contact the author
Table of contents

LYMPH NODE METASTASIS OF OSTEOSARCOMAS
LYMPH NODE METASTASIS OF OSTEOSARCOMAS

To cite this article:

Vasil'ev NV. Lymph node metastasis of osteosarcomas. Russian Journal of Archive of Pathology. 2016;78(4):58‑63. (In Russ.)
https://doi.org/10.17116/patol201678458-62

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Mali­gnancy of fibrous dysplasia of the calvarial bone in patient with McCune-Albright syndrome: clinical obse­rvation and lite­rature review. Burdenko's Journal of Neurosurgery. 2025;(4):87-97
Abstract:

Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its classification as clinical stage IV tumor. The risk factors for lymph node metastases in patients with bone sarcomas are age (≥64 years), gender (female), nosological entity (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), tumor depth (muscle, bone), and the size of primary tumor (>5 сm). The mechanism of lymph node metastasis of osteosarcomas seems to be related to mesenchymal-to-epithelial transition.

Keywords:

osteosarcoma
lymph node metastasis
risk factors for metastases
mesenchymal-to-epithelial transition

Authors:

Vasil'ev N.V.

FGBNU "Tomskiĭ NII onkologii", Tomsk, Rossiia, 634028

Close metadata

References:

  1. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, eds. WHO Classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC; 2013.
  2. Hogendoorn PCW. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010;21(Suppl.5):v204-v213. doi:10.1093/annonc/mdq223
  3. Thampi S, Matthay KK, Goldsby R, DuBois SG. Adverse impact of regional lymph node involvement in osteosarcoma. Eur J Cancer. 2013;49(16):3471-3476. doi:10.1016/j.ejca.2013.06.023
  4. Layfield LJ, Emerson L, Crim JR, Randall L. Squamous differentiation and cytokeratin expression in an osteosarcoma: a case report and review of the literature. Clin Med Pathol. 2008;1:55-59. Available et: http://creativecommons.org/licenses/by/3.0/
  5. Qureshi SS, Puri A, Agarwal M, Desai S, Jambhekar N. Recurrent giant cell tumor of bone with simultaneous regional lymph node and pulmonary metastases. Skeletal Radiol. 2005;34(4):225-228.  doi:10.1007/s00256-004-0824-4
  6. Hatori M, Ohtani H, Yamada N, Uzuki M, Kokubun S. Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report. Jpn J Clin Oncol. 2001;31(11):562-566.
  7. Lee N Y-T, Moore TM, Schwinn CP. Metastasis of sarcomatous lesion in regional lymph node. J Surg Oncol. 1982;20(1):53-58.
  8. Applebaum MA, Goldsby R, Neuhaus J, DuBois SG. Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement. Pediatr Blood Cancer. 2012;59(4):617-620.  doi:10.1002/pbc.24053
  9. Caceres E, Zaharia M, Calderon R. Incidence of regional lymph node metastasis in operable osteogenic sarcoma. Semin Surg Oncol. 1990;6(4):231-239.
  10. Jeffree GM, Price CHG, Sissons HA. The metastatic patterns of osteosarcoma. Br J Cancer. 1975;32:87-107.
  11. Yanagawa T, Saito K, Takagishi K. Risk factors for lymphatic metastasis of malignant bone and soft-tissue tumors: a retrospective cohort study of 242 patients. Medicine (Baltimore). 2014;93(27):e225. doi:10.1097/MD.0000000000000225
  12. Arkadera A, Morris CD. Lymphatic spread of pagetic osteogenic sarcoma detected by bone scan. Cancer Imaging. 2008;8:131-134.  doi:10.1102/1470-7330.2008.0021
  13. Chen JY, Sittampalam K, Selvarajan S, Tan MH. Atypical presentation of high-grade intramedullary osteosarcoma with bilateral cervical, supraclavicular, and axillary lymphadenopathy: a case report and literature review. Proc Singapore Healthcare. 2013;22(4):277-283.
  14. Dirik Y, Cinar A, Yumrukcal F, Eralp L. Popliteal lymph node metastasis of tibial osteoblastic osteosarcoma. Int J Surg Case Rep. 2014;5:840-844.  doi:10.1016/j.ijscr.2014.09.029
  15. Tobias JD, Pratt CB, Parham DM, Green AA, Rao B. The significance of calcifical regional lymph nodes at the time of diagnosis of osteosarcoma. Orthopedics. 1985;8:49-52.
  16. Weingrad DN, Rosenberg SA. Early lymphatic spread of osteogenic and soft-tissue sarcomas. Surgery. 1978;84(2):231-240.
  17. Zwaga T, Bovee JMG, Kroon HM. Osteosarcoma of the femur with skip, lymph node, and lung metastases. Radiographics. 2008;28:277-283.  doi:10.1148/rg.281075015
  18. Gulia A, Puri A, Jain S, Rekhi B, Juvekar S. Extraskeletal osteosarcoma with synchronous regional lymph node and soft tissue metastasis: a rare presentation of an uncommon tumour. Eur J Orthop Surg Traumatol. 2013;23(Suppl.2):317-321.  doi:10.1007/s00590-012-1097-6
  19. Huvos AG, Rosen G, Dabska M, Marcove RC. Mesenchymal chondrosarcoma. Cancer. 1983;51(7):1230-1237. doi:10.1002/1097-0142(19830401)51:7%3C1230::aid-cncr2820510710%3E3.0.co;2-q
  20. Herget GW, Uhl M, Opitz OG, Adler CP, Südkamp NP, Knöller S. The many faces of chondrosarcoma of bone. Acta Chir Orthop Traumatol Cech. 2011;78(6):501-509.
  21. Borbas P, Leithner A, Sadoghi P, Berndt A. Clonality assessment in a case of multifocal adamantinoma and a review of the literature. Case Rep Med. 2012;2012:ID 605685. doi:10.1155/2012/605685
  22. Ramaswamy AS, Chatura KR, Chandrasekhar HR. Metastatic or metachronous adamantinoma: An Enigma. Int J Appl Basic Med Res. 2012;2(2):132-135.  doi:10.1155/2012/605685
  23. Mokhtari S, Mirafsharieh A. Clear cell chondrosarcoma of the head and neck. Head Neck Oncol. 2012;4:13.  doi:10.1186/1758-3284-4-13
  24. Grunewald TGP, von Luettichau I, Weirich G, Wawer A, Behrends U, Prodinger PM et al. Sclerosing epithelioid fibrosarcoma of the bone: a case report of high resistance to chemotherapy and a survey of the literature. Sarcoma. 2010;2010:ID 431627. doi:10.1155/2010/431627
  25. Brewer P, Sumathi V, Grimer RJ, Carter SR, Tillman RM, Abudu A et al. Primary leiomyosarcoma of bone: analysis of prognosis. Sarcoma. 2012;2012:ID 636849. doi:10.1155/2012/636849
  26. Shiraishi J, Mukai M, Yabe H, Shibata R, Yamada T, Miura K et al. Primary bone carcinosarcoma: chondrosarcoma and squamous cell carcinoma with keratin pearl formation. Pathol Int. 2005;55:504-509.
  27. Chen Y, Shen D, Sun K, Bao D, Song Q, Wang G et al. Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome. Tumori. 2011;97(5):585-589.
  28. Sopta EGJ, Tulic EV, Mijucic EP, Mamontov E, Mandic N. Solitary lymph node metastasis without local recurrence of primary chordoma. Eur Spine J. 2009;18(Suppl.2):S191-S195. doi:10.1007/s00586-008-0800-0
  29. Chou WC, Hung YS, Lu CH, Yeh KY, Sheu S, Liaw CC. De novo dedifferentiated chordoma of the sacrum: a case report and review of the literature. Chang Gung Med J. 2009;32(3):330-335.
  30. Van Akkooi ACJ, van Geel AN, Bessems JHJM, den Bakker MA. Extra-axial chordoma. J Bone Jt Surg. 2006;88-B:1232-1234. doi:10.1302/0301-620X.88B9
  31. Viswanathan S, Jambhekar NA. Metastatic giant cell tumor of bone are there associated factors and best treatment modalities? Clin Orthop Relat Res. 2010;468:827-833.  doi:10.1007/s11999-009-0966-8
  32. Hong SW, Choi HY. Malignant giant cell tumor of the skull. J Korean Neurosurg Soc. 2004;36:324-327.
  33. Edwards JR, Williams K, Kindblom L-G, Meis-Kindblom JM, Hogendoorn P, Hughes D et al. Lymphatic and bone. Hum Pathol. 2008;39(1):49-55.  doi:10.1016/j.humpath.2007.04.022
  34. Tallroth K. Lymphatic dissemination of bone and soft tissue sarcomas: a lymphographic investigation. Acta Radiol. 1976;Suppl.349:1-84.
  35. Manskikh VN, Perelmuter VM. Collateral presentation of antigens as physiological prototype for lymph node metastases. Biochemistry (Moscow). 2013;78(3):314-323.  doi:10.1134/S0006297913030152
  36. Perelmuter VM, Manskikh VN. Preniche as missing link of the metastatic niche concept explaining organ-preferential metastasis of malignant tumors and the type of metastatic disease. Biochemistry (Moscow). 2012;77(1):111-118.  doi:10.1134/S0006297912010142
  37. Niinaka Y, Harada K, Fujimuro M, Oda M, Haga A, Hosoki M et al. Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. Cancer Res. 2010;70(22):9483-9493. doi:10.1158/0008-5472.CAN-09-3880
  38. Yang J, Du X, Wang G, Sun Y, Chen K, Zhu X et al. Mesenchymal to epithelial transition in sarcomas. Eur J Cancer. 2014;50(3):593-601.  doi:10.1016/j.ejca.2013.11.006
  39. Fitzgerald MP, Gourronc F, Teoh MLT, Provenzano MJ, Case J, Martin JA et al. Human chondrosarcoma cells acquire an epithelial-like gene expression pattern via an epigenetic switch: evidence for mesenchymal-epithelial transition during sarcomagenesis. Sarcoma. 2011;2011:ID 598218. doi:10.1155/2011/598218
  40. Deyrup AT, Montag AG. Epithelioid and epithelial neoplasms of bone. Arch Pathol Lab Med. 2007;131:205-216.
  41. Cacciatore M, Dei Tos AP. Challenging epithelioid mesenchymal neoplasms: mimics and traps. Pathology. 2014;46(2):126-134.  doi:10.1097/PAT.0000000000000063
  42. Deyrup AT. Epithelioid lesions. Surg Pathol. 2011;4(3):865-885.  doi:10.1016/j.path.2011.08.007
  43. Dabbs DJ. Diagnostic iimmunohistochemistry. Theranostic and genomic applications. Philadelphia: Saunders Elsevier; 2010.
  44. Schuetz AN, Rubin BP, Goldblum JR, Shehata B, Weiss SW, Liu W et al. Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. Mod Pathol. 2005;18:1403-1410. doi:10.1038/modpathol.3800435
  45. Greco N, Schott T, Mu X, Rothenberg A, Voigt C, McGough RL et al. ALDH activity correlates with metastatic potential in primary sarcomas of bone. J Cancer Ther. 2014;5(4):331-338.  doi:10.4236/jct.2014.54040
  46. Okada K, Hasegawa T, Yokoyama R, Beppu Y, Itoi E. Prognostic relevance of rosette-like features in osteosarcoma. J Clin Pathol. 2003;56:831-834.
  47. Greene F, Page D, Fleming F, Fritz AG. American Joint Committee on Cancer: Cancer staging manual. 6th ed. New York: Springer; 2002:221-226.
  48. Madsen EH. Lymph node metastases from osteoblastic osteogenic sarcoma visible on plain films. Skeletal Radiol. 1979;4:216-218.  doi:10.1007/bf00347216
  49. Miller ME, Emerson L, Clayton F, Bentz BG, Data RE, Salzman KL et al. Extraosseous Ewing’s sarcoma. J Clin Oncol. 2007;25(30):4845-4848. doi:10.1200/JCO.2007.13.0930
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.