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Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Poliakova V.O.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Oskolkova S.A.

Academician B.V. Petrovsky Russian Surgery Research Center, Moscow, Russia

Abramyan A.V.

B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia

Ivanova A.G.

otdelenie patologoanatomicheskoe I

Krylova Iu.S.

Gavrilenko A.V.

B.V. Petrovsky Russian Scientific Center of Surgery, Moscow, Russia;
Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of the Russia, Moscow, Russia

Expression of matrix metalloproteinases and their inhibitors in the internal carotid artery wall in pathological tortuosity

Authors:

Pal'tseva E.M., Poliakova V.O., Oskolkova S.A., Abramyan A.V., Ivanova A.G., Krylova Iu.S., Gavrilenko A.V.

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Journal: Russian Journal of Archive of Pathology. 2016;78(3): 26‑31

DOI: 10.17116/patol201678326-31

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EXPRESSION OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN THE INTERNAL CAROTID ARTERY WALL IN PATHOLOGICAL TORTUOSITY
EXPRESSION OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN THE INTERNAL CAROTID ARTERY WALL IN PATHOLOGICAL TORTUOSITY

To cite this article:

Pal'tseva EM, Poliakova VO, Oskolkova SA, Abramyan AV, Ivanova AG, Krylova IuS, Gavrilenko AV. Expression of matrix metalloproteinases and their inhibitors in the internal carotid artery wall in pathological tortuosity. Russian Journal of Archive of Pathology. 2016;78(3):26‑31. (In Russ.)
https://doi.org/10.17116/patol201678326-31

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The principal morphological sign of fibromuscular dysplasia in pathological tortuosity (PT) of the internal carotid artery (ICA) is the fragmentation of elastic fibers that are degraded by matrix metalloproteinases 2 and 9 (MMP-2, MMP-9). Nevertheless, the role of MMPs and their inhibitors in the pathogenesis of ICA PT remains completely unexplored. Objective: to investigate the expression of elastin-degrading MMPs and their inhibitors in the wall of the ICA in PT by immunohistochemistry and confocal laser scanning microscopy. Methods. Immunohistochemical examination was made using antibodies to MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2. MMP-9 and TIMP-1 levels were determined by confocal laser scanning microscopy. Results. Immunohistochemical examination revealed a statistically significant predominance of high concentrations of MMP-2 and MMP-9 and a low level of their inhibitor TIMP-1 in ICA PT, while simultaneous obvious accumulation of both markers was most often identified in the control group (p<0.05). Analysis of MMP-2/TIMP-2 and MMP-9/TIMP-2 ratios showed the prevalence of the simultaneously high expression of both proteins in ICA PT and in the control group too. The similar data were also obtained by confocal microscopy: the control group showed elevated MMP-9 and TIMP-1 expressions and the ICA PT control displayed a high proteinase and low inhibitor levels (p<0.05). Conclusion. Elastic fiber fragmentation in ICA PT is due to imbalance between MMPs and their inhibitors; namely, the prevalence of MMP-2 and MMP-9 over their inhibitor TIMP-1, which leads to the degradation of extracellular matrix components, primarily elastin.

Keywords:

pathological tortuosity of the internal carotid artery
matrix metalloproteinase 2
matrix metalloproteinase 9
tissue inhibitor of matrix metalloproteinases 1
tissue inhibitor of matrix metalloproteinases 2

Authors:

Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Poliakova V.O.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Oskolkova S.A.

Academician B.V. Petrovsky Russian Surgery Research Center, Moscow, Russia

Abramyan A.V.

B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia

Ivanova A.G.

otdelenie patologoanatomicheskoe I

Krylova Iu.S.

Gavrilenko A.V.

B.V. Petrovsky Russian Scientific Center of Surgery, Moscow, Russia;
Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of the Russia, Moscow, Russia

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References:

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