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Kopishinskaia S.V.

Kafedra nevrologii, psikhiatrii i narkologii fakul'teta povysheniia kvalifikatsii vracheĭ GBOU VPO "Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia", Nizhniĭ Novgorod

Gustov A.V.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia

Kolchanova T.V.

Pavlovo Central Regional Hospital, Nizhny Novgorod

Immunohistochemical examination of skin biopsy specimens with calculation of C fibers in the diagnosis of polyneuropathy

Authors:

Kopishinskaia S.V., Gustov A.V., Kolchanova T.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2015;77(2): 43‑49

DOI: 10.17116/patol201577243-49

Views: 1269

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To cite this article:

Kopishinskaia SV, Gustov AV, Kolchanova TV. Immunohistochemical examination of skin biopsy specimens with calculation of C fibers in the diagnosis of polyneuropathy. Russian Journal of Archive of Pathology. 2015;77(2):43‑49. (In Russ.)
https://doi.org/10.17116/patol201577243-49

Подписка 2025 (Russian Journal of Archive of Pathology)
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The paper discusses the anatomy of innervation of the skin, the epidermis and dermis in particular, which are related to pain, the markers of skin nerves and cells. It gives data on the diagnosis of fine unmyelinated fibers, by immunohistochemically examining skin biopsy specimens. The paper also describes the morphometry of skin nerves: intraepidermal nerve fibers, dermal nerve fibers, and autonomic nerve fibers. It discusses whether a skin biopsy specimen may be used to diagnose polyneuropathies of different etiology: diabetic, immune, HIV-related, and hereditary ones.

Keywords:

immunohistochemistry of skin biopsy specimen; unmyelinated C fibers
ubiquitin C-terminal hydroxylase
PGP 95
intraepidermal nerve fibers

Authors:

Kopishinskaia S.V.

Kafedra nevrologii, psikhiatrii i narkologii fakul'teta povysheniia kvalifikatsii vracheĭ GBOU VPO "Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia", Nizhniĭ Novgorod

Gustov A.V.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia

Kolchanova T.V.

Pavlovo Central Regional Hospital, Nizhny Novgorod

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