The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Kazubskaya T.P.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Kozlova V.M.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia;
Research Centre for Medical Genetics, Moscow, Russia
Kondrat'eva T.T.
FGBU "Moskovskiĭ onkologicheskiĭ nauchnyĭ tsentr im. N.N. Blokhina" RAMN, Moskva
Pavlovskaya A.I.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Marakhonov A.V.
FGBU "Meditsinskiĭ geneticheskiĭ nauchnyĭ tsentr" RAMN, Moskva
Baranova A.V.
FGBU "Meditsinskiĭ geneticheskiĭ nauchnyĭ tsentr" RAMN, Moskva
Ivanova N.I.
Kafedra otorinolaringologii
Stepanova A.A.
FGBU "Meditsinskiĭ geneticheskiĭ nauchnyĭ tsentr" RAMN, Moskva
Poliakov A.V.
Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN, Moskva
Belev N.F.
Institut onkologii Moldovy, Kishinev
Brzhezovsky V.Zh.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Follicular cell (papillary and follicular) thyroid carcinoma, genetic inheritance, and molecular diagnostic markers
Journal: Russian Journal of Archive of Pathology. 2014;76(5): 3‑12
Views: 7611
Downloaded: 152
To cite this article:
Kazubskaya TP, Kozlova VM, Kondrat'eva TT, et al. . Follicular cell (papillary and follicular) thyroid carcinoma, genetic inheritance, and molecular diagnostic markers. Russian Journal of Archive of Pathology. 2014;76(5):3‑12. (In Russ.)
Objective - to determine the genetic forms of follicular cell thyroid carcinoma (FCTC) (papillary and follicular thyroid carcinoma (PTC and FTC)), to identify criteria to individually predict the development of the same disease for relatives, and to assess the role of molecular markers in the diagnosis, prognosis, and treatment of this disease. Subjects and methods. One hundred and ninety adult patients aged 20 to 84 years with histologically verified PTC and FTC and 20 children (12 patients with PTC and 8 with benign thyroid tumors) aged 2 to 16 years were examined. To assess the role of the BRAF gene as a molecular marker for thyroid carcinoma, DNA was isolated from the thyroid tumor tissue of 29 patients, which had been obtained by fine-needle aspiration biopsy (FNAB) and scraping and swabbing the cytological specimen previously showing an area containing tumor cells. A BRAF с.1799Т>А (р.V600E) mutation in the FNAB specimens was tested by allele-specific ligation, followed by PCR amplification. Results. The examinees' families were found to have a segregation of benign thyroid tumor and nontumor diseases (13.6%). Neoplasias of different sites were observed in 15% of the patients' relatives. Multiple primary tumors were detected in 6.1% of the patients and in 25% of the examined children (3/12). PTC was ascertained to accumulate as two clinical forms in the families. One form belongs to familial PTC (FPTC) in which two or three generations of relatives in the family are afflicted by only PTC and have a more severe phenotype of the disease. The other includes an association of FPTC with papillary kidney cancer. Furthermore, FPTC and PTC may be a component of multitumor syndromes, such as multiple endocrine neoplasia type 1, Cowden syndrome, and familial adenomatous polyposis. The familial hereditary forms of FCTC were generally revealed in 4.2% of the patients. BRAF v600E mutations were found in only 3 patients with Stages II and III PTC and were not in all the 12 children with PTC. Conclusion. The found clinical manifestation of the hereditary forms of FCTC permits the identification of people at high risk for this disease. No correlation between somatic BRAF mutations with a less favorable course in PTC can be noticed because there are few observations. Analysis of published data on the role of molecular markers in FCTC has shown that the existing specific somatic changes complement information in the differential cytological diagnosis when examining FNAB specimens.
Keywords:
Authors:
Kazubskaya T.P.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Kozlova V.M.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia;
Research Centre for Medical Genetics, Moscow, Russia
Kondrat'eva T.T.
FGBU "Moskovskiĭ onkologicheskiĭ nauchnyĭ tsentr im. N.N. Blokhina" RAMN, Moskva
Pavlovskaya A.I.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
Marakhonov A.V.
FGBU "Meditsinskiĭ geneticheskiĭ nauchnyĭ tsentr" RAMN, Moskva
Baranova A.V.
FGBU "Meditsinskiĭ geneticheskiĭ nauchnyĭ tsentr" RAMN, Moskva
Ivanova N.I.
Kafedra otorinolaringologii
Stepanova A.A.
FGBU "Meditsinskiĭ geneticheskiĭ nauchnyĭ tsentr" RAMN, Moskva
Poliakov A.V.
Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN, Moskva
Belev N.F.
Institut onkologii Moldovy, Kishinev
Brzhezovsky V.Zh.
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.