The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Egorova I.F.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Sukhacheva T.V.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Serov R.A.

Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva RAMN, Moskva

Skopin I.I.

A.N. Bakoulev Research Center for Cardiovascular Surgery of RAS (director — acad.of RAS L.A. Bokeria), Moscow, Russia

Nikitina T.G.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Mironenko V.A.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Irodova N.L.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Kuts E.V.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Cardiomyocyte structural rearrangement in patients with dilated cardiomyopathy and valvular heart disease

Authors:

Egorova I.F., Sukhacheva T.V., Serov R.A., Skopin I.I., Nikitina T.G., Mironenko V.A., Irodova N.L., Kuts E.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2012;74(4): 3‑7

Read: 1353 times

Download PDF (RU)
Contact the author
Table of contents

CARDIOMYOCYTE STRUCTURAL REARRANGEMENT IN PATIENTS WITH DILATED CARDIOMYOPATHY AND VALVULAR HEART DISEASE
CARDIOMYOCYTE STRUCTURAL REARRANGEMENT IN PATIENTS WITH DILATED CARDIOMYOPATHY AND VALVULAR HEART DISEASE

To cite this article:

Egorova IF, Sukhacheva TV, Serov RA, et al. . Cardiomyocyte structural rearrangement in patients with dilated cardiomyopathy and valvular heart disease. Russian Journal of Archive of Pathology. 2012;74(4):3‑7. (In Russ.)

 
Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Light and electron microscopies were used to analyze cardiomyocyte structural changes in the dilated left ventricle in patients with dilated cardiomyopathy and valvular heart diseases. The patients were found to have cardiomyocyte hypertrophy and ultrastructural rearrangement with a tissue-specific reduction. There was hypertrophic cardiomyocyte lengthening that continued after these cells stopped growing thicker, as well as occurred due to the loss of myofibrils, which increased during the cell rearrangement, and directly correlated with the lower ejection fraction and higher end-systolic volume of the left ventricle.

Keywords:

cardiac dilation
cardiomyocyte sizes and ultrastructure

Authors:

Egorova I.F.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Sukhacheva T.V.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Serov R.A.

Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva RAMN, Moskva

Skopin I.I.

A.N. Bakoulev Research Center for Cardiovascular Surgery of RAS (director — acad.of RAS L.A. Bokeria), Moscow, Russia

Nikitina T.G.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Mironenko V.A.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Irodova N.L.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Kuts E.V.

FGBU "Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva" RAMN, Moskva

Close metadata

References:

  1. Egorova I.F., Serov R.A., Plotnikova L.R., Amirkulov B.D. Utrata miofibrill - proyavlenie otnositel'noi dedifferentsirovki gipertrofirovannykh kardiomiotsitov. Morfologiya 2004; 126: 5: 37-40.
  2. Egorova I.F., Sukhacheva T.V., Serov R.A. Uvelichenie dliny kardiomiotsitov kak element dilatatsii polostei gipertrofirovannogo serdtsa (obzor literatury). Byul NTsSSKh im. A.N. Bakuleva RAMN "Serdechno-sosudistye zabolevaniya" 2011; 12: 1: 35-42.
  3. Beltrami C. A., Finato N., Rocco M. et al. The cellular basis of dilated cardiomyopathy in humans. J Mol Cell Cardiol 1995; 27: 1: 291-305.
  4. Ferrans V.J. Ultrastructure of degenerated muscle cells in patients with cardiac hypertrophy. In: Riecker G., Weber A., Goodwin J., eds. Myocardial failure (International Boehringer Mannheim symposia). Berlin: 1977; 185-200.
  5. Gerdes A.M., Kellerman S.E., Moore J.A. et al. Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy. Circulation 1992; 86: 426-430.
  6. Gerdes A.M. Cardiac myocyte remodeling in hypertrophy and progression to failure. J Card Fail 2002; 8: 6: Suppl: 264-268.
  7. Grossman W., Jones D., McLaurin L.P. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 1975; 56: 56-64.
  8. Kajstura J., Zhang X., Liu Y. et al. The cellular basis of pacing-induced dilated cardiomyopathy: myocyte cell loss and myocyte cellular reactive hypertrophy. Circulation 1995; 92: 2306-2317.
  9. Kawamura K. Cardiac hypertrophy - scanned architecture, ultrastructure and cytochemistry of myocardial cells. Jpn Circ J 1982; 46: 9: 1012-1030.
  10. Kunkel B., Lapp H., Kober G. et al. Light-microscopic evaluation of myocardial biopsies. In: Kaltenbach M., Loogen F., Olsen E.G.J., eds. Cardiomyopathy and myocardial biopsy. Berlin 1978; 62-70.
  11. Kunkel B., Schneider M. Myocardial structure and left ventricular function in hypertrophic and dilative cardiomyopathy and aortic valve disease. Z Kardiol 1987; 76: Suppl. 3: 9-13.
  12. Sawada K., Kawamura K. Architecture of myocardial cells in human cardiac ventricles with concentric and eccentric hypertrophy as demonstrated by quantitative scanning electron microscopy. Heart Vessels 1991; 6: 3: 129-142.
  13. Schaper J., Froede R., Hein St. et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 1991; 83: 504-514.
  14. Tamura T., Onodera T., Said S. et al. Correlation of myocyte lengthening to chamber dilation in the spontaneously hypertensive heart failure (SHHF) rat. J Mol Cell Cardiol 1998; 30: 11: 2175-2181.
  15. Vliegen H.W., van der Laarse A., Huysman J.A.N. et al. Morphometric quantification of myocyte dimensions validated in normal growing rat hearts and applied to hypertrophic human hearts. Cadiovasc Res 1987; 21: 352-357.
  16. Wang X., Li F., Gerdes A.M. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs. I. Regional hemodynamics and myocyte remodeling. J Mol Cell Cardiol 1999; 31: 307-317.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.