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Turgunov Ye.M.

Karaganda Medical University

Ogizbayeva A.V.

Karaganda Medical University

Mugazov M.M.

Karaganda Medical University

Asamidanova S.G.

Karaganda Medical University

Biomarkers of intestinal wall damage in multiple organ dysfunction syndrome

Authors:

Turgunov Ye.M., Ogizbayeva A.V., Mugazov M.M., Asamidanova S.G.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(2): 114‑120

DOI: 10.17116/anaesthesiology2024021114

Read: 1234 times

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Table of contents

BIOMARKERS OF INTESTINAL WALL DAMAGE IN MULTIPLE ORGAN DYSFUNCTION SYNDROME
BIOMARKERS OF INTESTINAL WALL DAMAGE IN MULTIPLE ORGAN DYSFUNCTION SYNDROME

To cite this article:

Turgunov YeM, Ogizbayeva AV, Mugazov MM, Asamidanova SG. Biomarkers of intestinal wall damage in multiple organ dysfunction syndrome. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):114‑120. (In Russ.)
https://doi.org/10.17116/anaesthesiology2024021114

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Abstract:

Increased intestinal wall permeability and impaired barrier function in ICU patients are due to microcirculation disorders, ischemia and hypoxia of intestinal wall. As a result, bacteria and/or their endotoxins penetrate the damaged intestinal wall, enhance immune response and can lead to systemic inflammation, multiple organ dysfunction syndrome, sepsis and even death. This review is devoted to mechanisms of intestinal barrier disruption and the most effective serum biomarkers of intestinal wall damage: zonulin, intestinal fatty acid binding protein (I-FABP) and regenerating islet-derived 3-alpha (REG3α), citrulline. Despite various study limitations, these biomarkers are interesting candidates for identifying patients with high risk of complications and screening for timely intensive care measures. These approaches can reduce ICU-stay and mortality.

Keywords:

multiple organ dysfunction syndrome
MODS
biomarkers of intestinal wall damage
I-FABP
REG3α
zonulin
citrulline

Authors:

Turgunov Ye.M.

Karaganda Medical University

Ogizbayeva A.V.

Karaganda Medical University

Mugazov M.M.

Karaganda Medical University

Asamidanova S.G.

Karaganda Medical University

Received:

03.11.2023

Accepted:

12.12.2023

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