Extracorporeal detoxification in complex treatment of severe acute pancreatitis

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Acute pancreatitis is one of the most life-threatening urgent surgical diseases. Mortality rate in severe acute pancreatitis is still high. Nevertheless, mortality is being decreased over the past decades. Endogenous intoxication is the main pathogenetic factor causing multiple organ failure in severe acute pancreatitis. Therefore, detoxification therapy is particularly important aspect in the complex treatment. Extracorporeal detoxification is potentially the most effective for endogenous intoxication and prevention of progression of multiple organ lesion. To date, clear approaches to these techniques have not been formed in the early phase of disease. We have analyzed literature data devoted to extracorporeal detoxification in severe acute pancreatitis and determined the recommendations for these techniques in intensive care.

Keywords:

severe acute pancreatitis

hemofiltration

hemodiafiltration

plasma exchange

Authors:

Marukhov A.V.

Kirov Military Medical Academy

Khoroshilov S.E.

Negovsky Research Institute of General Reanimatology of the Federal Research and Clinical Center for Reanimatology and Rehabilitology;
Burdenko Main Military Clinical Hospital

SPIN RSCI: 7071-6642
Scopus AuthorID: 56737015600
ResearcherID: V-1770-2017
ORCID: 0000-0002-0427-8099

Zakharov M.V.

Kirov Military Medical Academy

Nikulin A.V.

Negovsky Research Institute of General Reanimatology of the Federal Research and Clinical Center for Reanimatology and Rehabilitology;
Burdenko Main Military Clinical Hospital

Chubchenko N.V.

Kirov Military Medical Academy

Received:

29.05.2020

Accepted:

15.06.2020

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