The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Kulikov A.V.

Shifman E.M.

M.F. Vladimirsky Moscow Regional Research Clinical Institute, Ministry of Health of the Moscow Region, Moscow, Russia

Protsenko D.N.

GBUZ «City clinical hospital named after S.S. Yudin» of Moscow health department, Moscow, Russia;
FGBOU VO «Russian national research medical University named after N.I. Pirogov» of Ministry of health of Russia, Moscow, Russia

Schegolev A.V.

N.N. Burdenko Main Military Clinical Hospital, Moscow, Russia ,SM Kirov Military Medical Academy, St. Petersburg, Russia

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Artymuk N.V.

kafedra akusherstva i ginekologii #2 Kemerovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Belokrinitskaia T.E.

Kafedra akusherstva i ginekologii fakul'teta povysheniia kvalifikatsii i poslediplomnoĭ podgotovki spetsialistov Chitinskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Zabolotskikh I.B.

FGBOU VO «Kuban State Medical University» Ministry of Health of Russia, Krasnodar, Russia

Ovezov A.M.

MONIKI, Moscow, Russia

Ronenson A.M.

SBIH TR «Regional Clinical Perinatal Center named E.M. Bakunina», Tver, Russia

Filippov O.S.

Departament razvitiia meditsinskoĭ pomoshchi detiam i sluzhby rodovspomozheniia Ministerstva zdravookhraneniia i sotsial'nogo razvitiia Rossiĭskoĭ Federatsii, Moskva

Shlyapnikov S.A.

Mechnikov North-West State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg

Initial septic shock therapy in obstetrics (clinical guidelines)

Authors:

Kulikov A.V., Shifman E.M., Protsenko D.N., Schegolev A.V., Adamyan L.V., Artymuk N.V., Belokrinitskaia T.E., Zabolotskikh I.B., Ovezov A.M., Ronenson A.M., Filippov O.S., Shlyapnikov S.A.

More about the authors

Read: 5212 times


To cite this article:

Kulikov AV, Shifman EM, Protsenko DN, et al. . Initial septic shock therapy in obstetrics (clinical guidelines). Russian Journal of Anesthesiology and Reanimatology. 2019;(5):5‑21. (In Russ.)
https://doi.org/10.17116/anaesthesiology20190515

Recommended articles:
Neurometabolic therapy with Cere­brolysin in patients with sepsis-associated ence­phalopathy. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):46-54
Nutritional support for sepsis: is there a single concept?. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):70-78
Biomarkers of acute cere­bral damage in complex diagnosis of sepsis-associated ence­phalopathy. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):6-13
Resting energy expe­nditure asse­ssment needs in patients with pancreatogenic sepsis. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):26-33
The role of neutrophils in the mechanisms of sepsis. Russian Journal of Archive of Pathology. 2024;(6):82-91
Septic complications after abdo­minal deli­very (literature review). Russian Journal of Human Reproduction. 2024;(6):108-117
Prognostic model of a patient with sepsis readiness to early mobi­lization with assi­stance. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(2):26-26

References:

  1. Septicheskie oslozhneniya v akusherstve. Klinicheskie rekomendatsii (protokoly lecheniya) MZ RF №15-4/10/2-738 ot 06.02.17. 59 s.
  2. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-810. https://doi.org/10.1001/jama.2016.0287
  3. World Health Organization. Statement on maternal sepsis. Geneva: WHO; 2017. Accessed 20 Feb 2017. 4 p.
  4. Bonet M, Nogueira Pileggi V, Rijken MJ, Coomarasamy A, et al. Towards a consensus definition of maternal sepsis: results of a systematic review and expert consultation. Reprod Health. 2017 May 30;14(1):67. https://doi.org/10.1186/s12978-017-0321-6
  5. Society for Maternal-Fetal Medicine (SMFM), Plante LA, Pacheco LD, Louis JM. SMFM Consult Series #: Sepsis during pregnancy and the puerperium. Am J Obstet Gynecol. 2019 Jan 23. pii: S0002-9378(19)30246-7. https://doi.org/10.1016/j.ajog.2019.01.216
  6. Turner MJ. Maternal sepsis is an evolving challenge. Int J Gynaecol Obstet. 2019 Jul;146(1):39-42. https://doi.org/10.1002/ijgo.12833
  7. Foeller ME, Gibbs RS. Maternal sepsis: new concepts, new practices. Curr Opin Obstet Gynecol. 2019 Apr;31(2):90-96. https://doi.org/10.1097/GCO.0000000000000523
  8. Osterbur K, Mann FA, Kuroki K, DeClue A. Multiple organ dysfunction syndrome in humans and animals. J Vet Intern Med. 2014 Jul-Aug;28(4):1141-1151. https://doi.org/10.1111/jvim.12364
  9. Karasu E, Nilsson B, Köhl J, Lambris JD, Huber-Lang M. Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction. Front Immunol. 2019 Mar 21;10:543. https://doi.org/10.3389/fimmu.2019.00543
  10. Ziesmann MT, Marshall JC. Multiple Organ Dysfunction: The Defining Syndrome of Sepsis. Surg Infect (Larchmt). 2018 Feb/Mar;19(2):184-190. https://doi.org/10.1089/sur.2017.298
  11. Cecconi M, De Backer D, Antonelli M, Beale R, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014 Dec;40(12):1795-1815. https://doi.org/10.1007/s00134-014-3525-z
  12. Arulkumaran N, Singer M. Puerperal sepsis. Best Pract Res Clin Obstet Gynaecol. 2013 Dec;27(6):893-902. https://doi.org/10.1016/j.bpobgyn.2013.07.004
  13. Buddeberg BS, Aveling W. Puerperal sepsis in the 21st century: progress, new challenges and the situation worldwide. Postgrad Med J. 2015 Oct;91(1080):572-578. https://doi.org/10.1136/postgradmedj-2015-133475
  14. Adorno M. Sepsis in the Obstetric Client. Crit Care Nurs Clin North Am. 2018 Sep;30(3):415-422. https://doi.org/10.1016/j.cnc.2018.05.012
  15. Miko E, Meggyes M, Doba K, Barakonyi A, et al. Immune Checkpoint Molecules in Reproductive Immunology. Front Immunol. 2019 Apr 18;10:846. https://doi.org/10.3389/fimmu.2019.00846
  16. Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019 Jan 11;4(31). pii: eaat6114. https://doi.org/10.1126/sciimmunol.aat6114
  17. Rambaldi MP, Weiner E, Mecacci F, Bar J, et al. Immunomodulation and preeclampsia. Best Pract Res Clin Obstet Gynaecol. 2019 Jun 24. pii:S1521-6934(19)30084-7. https://doi.org/10.1016/j.bpobgyn.2019.06.005
  18. Mohamed-Ahmed O, Nair M, Acosta C, Kurinczuk JJ, et al. Progression from severe sepsis in pregnancy to death: a UK population-based case-control analysis. BJOG. 2015 Oct;122(11):1506-1515. https://doi.org/10.1111/1471-0528.13551
  19. Al-Ostad G, Kezouh A, Spence AR, Abenhaim HA. Incidence and risk factors of sepsis mortality in labor, delivery and after birth: population-based study in the USA. J Obstet Gynaecol Res. 2015 Aug;41(8):1201-1206. https://doi.org/10.1111/jog.12710
  20. Chebbo A, Tan S, Kassis C, Tamura L, Carlson RW. Maternal Sepsis and Septic Shock. Crit Care Clin. 2016 Jan;32(1):119-135. https://doi.org/10.1016/j.ccc.2015.08.010
  21. Eschenbach DA. Treating spontaneous and induced septic abortions. Obstet Gynecol. 2015 May;125(5):1042-1048. https://doi.org/10.1097/AOG.0000000000000795
  22. Knowles SJ, O’Sullivan NP, Meenan AM, Hanniffy R, et al. Maternal sepsis incidence, aetiology and outcome for mother and fetus: a prospective study. BJOG. 2015 Apr;122(5):663-671. https://doi.org/10.1111/1471-0528.12892
  23. Netto CM, Whitten M, Shetty N. Postpartum sepsis. Br J Hosp Med (Lond). 2015 Aug;76(8):118-121. https://doi.org/10.12968/hmed.2015.76.8.C118
  24. Oud L. Pregnancy-associated severe sepsis. Curr Opin Obstet Gynecol. 2016 Apr;28(2):73-8. https://doi.org/10.1097/GCO.0000000000000250
  25. Say L, Chou D, Gemmill A, Tunçalp Ö, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014 Jun;2(6): e323-333. https://doi.org/10.1016/S2214-109X(14)70227-X
  26. Committee on Obstetric Practice. Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection. Obstet Gynecol. 2017 Aug;130(2):e95-e101. https://doi.org/10.1097/AOG.0000000000002236
  27. Burlinson CEG, Sirounis D, Walley KR, Chau A. Sepsis in pregnancy and the puerperium. Int J Obstet Anesth. 2018 Jun 16. pii: S0959-289X(17)30463-6. https://doi.org/10.1016/j.ijoa.2018.04.010
  28. Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther. 2012 Jun;10(6):701-706. https://doi.org/10.1586/eri.12.50
  29. Kendle AM, Louis J. Recognition and Treatment of Sepsis in Pregnancy. J Midwifery Womens Health. 2018 May;63(3):347-351. https://doi.org/10.1111/jmwh.12740
  30. Bauer ME, et al. Maternal sepsis mortality and morbidity during hospitalization for delivery: temporal trends and independent associations for severe sepsis. Anesth Analg. 2013 Oct;117(4):944-950. https://doi.org/10.1213/ANE.0b013e3182a009c3
  31. Pacheco LD, Saade GR, Hankins GD. Severe sepsis during pregnancy. Clin Obstet Gynecol. 2014 Dec;57(4):827-834. https://doi.org/10.1097/GRF.0000000000000066
  32. Vincent JL, Jones G, David S, Olariu E, Cadwell KK. Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis. Crit Care. 2019 May 31;23(1):196. https://doi.org/10.1186/s13054-019-2478-6
  33. Luhr R, Cao Y, Söderquist B, Cajander S. Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002—2016. Crit Care. 2019 Jul 3;23(1):241. https://doi.org/10.1186/s13054-019-2528-0
  34. Materinskaya smertnost' v Rossiiskoi Federatsii v 2016 godu (metodicheskoe pis'mo Ministerstva zdravookhraneniya Rossiiskoi Federatsii) №15-4/10/2-7339 ot 23.10.17. 90 s.
  35. Barton JR, Sibai BM Severe sepsis and septic shock in pregnancy. Obstet Gynecol. 2012 Sep;120(3):689-706. https://doi.org/10.1097/AOG.0b013e318263a52d
  36. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644-1655. https://doi.org/10.1378/chest.101.6.1644
  37. Levy MM, Fink MP, Marshall JC, Abraham E, et al. SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003 Apr;31(4):1250-1256. https://doi.org/10.1097/01.CCM.0000050454.01978.3B
  38. Rhodes A, Evans LE, Alhazzani W, Levy MM, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. https://doi.org/10.1007/s00134-017-4683-6
  39. Keeley A, Hine P, Nsutebu E. The recognition and management of sepsis and septic shock: a guide for non-intensivists. Postgrad Med J. 2017 Oct;93(1104):626-634. https://doi.org/10.1136/postgradmedj-2016-134519
  40. Parfitt SE, Hering SL. Recognition and Management of Sepsis in the Obstetric Patient. AACN Adv Crit Care. 2018 Fall;29(3):303-315. https://doi.org/10.4037/aacnacc2018171
  41. Richter DC, Heininger A, Schmidt K, Schmoch T, et al. Diagnostic Approaches in Sepsis — Part 1: General Diagnostic Principles, Focus Identification and Source Control. Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Jan;54(1):22-36. https://doi.org/10.1055/a-0625-5507
  42. Sepsis: recognition, diagnosis and early management: © NICE (2017) Sepsis: recognition, diagnosis and early management. BJU Int. 2018 Apr;121(4):497-514. https://doi.org/10.1111/bju.14179
  43. Jiang J, Yang J, Mei J, Jin Y, Lu Y. Head-to-head comparison of qSOFA and SIRS criteria in predicting the mortality of infected patients in the emergency department: a meta-analysis. Scand J Trauma Resusc Emerg Med. 2018 Jul 11;26(1):56. https://doi.org/10.1186/s13049-018-0527-9
  44. Shankar-Hari M, Phillips GS, Levy ML, et al. Sepsis Definitions Task Force. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):775-787. https://doi.org/10.1001/jama.2016.0289
  45. Song JU, Sin CK, Park HK, Shim SR, Lee J. Performance of the quick Sequential (sepsis-related) Organ Failure Assessment score as a prognostic tool in infected patients outside the intensive care unit: a systematic review and meta-analysis. Crit Care. 2018 Feb 6;22(1):28. https://doi.org/10.1186/s13054-018-1952-x
  46. Bowyer L, Robinson HL, Barrett H, Crozier TM, et al. SOMANZ guidelines for the investigation and management sepsis in pregnancy. Aust N Z J Obstet Gynaecol. 2017 Oct;57(5):540-551. https://doi.org/10.1111/ajo.12646
  47. Maitra S, Som A, Bhattacharjee S. Accuracy of quick Sequential Organ Failure Assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria for predicting mortality in hospitalized patients with suspected infection: a meta-analysis of observational studies. Clin Microbiol Infect. 2018 Nov;24(11):1123-1129. https://doi.org/10.1016/j.cmi.2018.03.032
  48. Serafim R, Gomes JA, Salluh J, Póvoa P. A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality: A Systematic Review and Meta-Analysis. Chest. 2018 Mar;153(3):646-655. https://doi.org/10.1016/j.chest.2017.12.015
  49. Jiang J, Yang J, Mei J, Jin Y, Lu Y. Head-to-head comparison of qSOFA and SIRS criteria in predicting the mortality of infected patients in the emergency department: a meta-analysis. Scand J Trauma Resusc Emerg Med. 2018 Jul 11;26(1):56. https://doi.org/10.1186/s13049-018-0527-9
  50. Bauer ME, Housey M, Bauer ST, Behrmann S, et al. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study. Anesth Analg. 2018 Aug 29. https://doi.org/10.1213/ANE.0000000000003709
  51. Song JU, Sin CK, Park HK, Shim SR, Lee J. Performance of the quick Sequential (sepsis-related) Organ Failure Assessment score as a prognostic tool in infected patients outside the intensive care unit: a systematic review and meta-analysis. Crit Care. 2018 Feb 6;22(1):28. https://doi.org/10.1186/s13054-018-1952-x
  52. Khwannimit B, Bhurayanontachai R, Vattanavanit V. Comparison of the performance of SOFA, qSOFA and SIRS for predicting mortality and organ failure among sepsis patients admitted to the intensive care unit in a middle-income country. J Crit Care. 2018 Apr;44:156-160. https://doi.org/10.1016/j.jcrc.2017.10.023
  53. Raith EP, Udy AA, Bailey M, Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE). Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit. JAMA. 2017 Jan 17;317(3):290-300. https://doi.org/10.1001/jama.2016.20328
  54. De Oliveira VM, Moraes RB, Stein AT, Wendland EM. Accuracy of C — Reactive protein as a bacterial infection marker in critically immunosuppressed patients: A systematic review and meta-analysis. J Crit Care. 2017 Dec;42:129-137. https://doi.org/10.1016/j.jcrc.2017.07.025
  55. Yang HS, Hur M, Yi A, Kim H, Lee S, Kim SN. Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis. PLoS One. 2018 Jan 24;13(1):e0191486. https://doi.org/10.1371/journal.pone.0191486
  56. Baumann BM, Greenwood JC, Lewis K, et al. Combining qSOFA criteria with initial lactate levels: Improved screening of septic patients for critical illness. Am J Emerg Med. 2019 Jul 4. pii: S0735-6757(19)30450-4. https://doi.org/10.1016/j.ajem.2019.07.003
  57. Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 Update. Crit Care Med. 2018 Jun;46(6):997-1000. https://doi.org/10.1097/CCM.0000000000003119
  58. Vardon-Bounes F, Ruiz S, Gratacap MP, Garcia C, et al. Platelets Are Critical Key Players in Sepsis. Int J Mol Sci. 2019 Jul 16;20(14). pii: E3494. https://doi.org/10.3390/ijms20143494
  59. Assinger A, Schrottmaier WC, Salzmann M, Rayes J. Platelets in Sepsis: An Update on Experimental Models and Clinical Data. Front Immunol. 2019 Jul 17;10:1687. https://doi.org/10.3389/fimmu.2019.01687
  60. Shim BS, Yoon YH, Kim JY, et al. Clinical Value of Whole Blood Procalcitonin Using Point of Care Testing, Quick Sequential Organ Failure Assessment Score, C-Reactive Protein and Lactate in Emergency Department Patients with Suspected Infection. J Clin Med. 2019 Jun 12;8(6). pii: E833. https://doi.org/10.3390/jcm8060833
  61. Pan J, Peng M, Liao C, Hu X, Wang A, Li X. Relative efficacy and safety of early lactate clearance-guided therapy resuscitation in patients with sepsis: A meta-analysis. Medicine (Baltimore). 2019 Feb;98(8):e14453. https://doi.org/10.1097/MD.0000000000014453
  62. Tan M, Lu Y, Jiang H, Zhang L. The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: A systematic review and meta-analysis. J Cell Biochem. 2019 Apr;120(4):5852-5859. https://doi.org/10.1002/jcb.27870
  63. Shafiq N, Gautam V, Pandey AK, et al. A meta-analysis to assess usefulness of procalcitonin-guided antibiotic usage for decision making. Indian J Med Res. 2017 Nov;146(5):576-584. https://doi.org/10.4103/ijmr.IJMR_613_15
  64. Wirz Y, Meier MA, Bouadma L, Luyt CE, et al. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit Care. 2018 Aug 15;22(1):191. https://doi.org/10.1186/s13054-018-25-7
  65. Chengfen Y, Tong L, Xinjing G, Zhibo L, Lei X. Accuracy of procalcitonin for diagnosis of sepsis in adults: a Meta-analysis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Sep;27(9):743-749.
  66. Westwood M, Ramaekers B, Whiting P, Tomini F, et al. Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015 Nov;19(96):v-xxv,1-236. https://doi.org/10.3310/hta19960
  67. Bartoletti M, Antonelli M, Bruno Blasi FA, Casagranda I, et al. Procalcitonin-guided antibiotic therapy: an expert consensus. Clin Chem Lab Med. 2018 Jul 26;56(8):1223-1229. https://doi.org/10.1515/cclm-2018-0259
  68. Blumenthal EA, Hooshvar N, McQuade M, McNulty J. A Validation Study of Maternal Early Warning Systems: A Retrospective Cohort Study. Am J Perinatol. 2019 Mar 11. https://doi.org/10.1055/s-0039-1681097
  69. Robbins T, Shennan A, Sandall J. Modified early obstetric warning scores: A promising tool but more evidence and standardization is required. Acta Obstet Gynecol Scand. 2019 Jan;98(1):7-10. https://doi.org/10.1111/aogs.13448
  70. Ryan HM, Jones MA, Payne BA, Sharma S, et al. Validating the Performance of the Modified Early Obstetric Warning System Multivariable Model to Predict Maternal Intensive CareUnit Admission. J Obstet Gynaecol Can. 2017 Sep;39(9):728-733.e3. https://doi.org/10.1016/j.jogc.2017.01.028
  71. Agarwal R, Yadav RK, Mohta M, Sikka M, et al. Sepsis in Obstetrics Score (SOS) utility and validation for triaging patients with obstetric sepsis in the emergency department: Evidence from a low income health care setting. Obstet Med. 2019 Jun;12(2):90-96. https://doi.org/10.1177/1753495X18761522
  72. Albright CM, Has P, Rouse DJ, Hughes BL. Internal Validation of the Sepsis in Obstetrics Score to Identify Risk of Morbidity From Sepsis in Pregnancy. Obstet Gynecol. 2017 Oct;130(4):747-755. https://doi.org/10.1097/AOG.0000000000002260
  73. Aarvold AB, Ryan HM, Magee LA, von Dadelszen P, et al. Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients. Crit Care Med. 2017 Jan;45(1):e49-e57. https://doi.org/10.1097/CCM.0000000000002018
  74. Plante LA. Management of Sepsis and Septic Shock for the Obstetrician-Gynecologist. Obstet Gynecol Clin North Am. 2016 Dec;43(4):659-678. https://doi.org/10.1016/j.ogc.2016.07.010
  75. Ding XF, Yang ZY, Xu ZT, Li LF, et al. Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials. J Transl Med. 2018 Nov 29;16(1):331. https://doi.org/10.1186/s12967-018-1700-7
  76. Chen X, Zhu W, Tan J, Nie H, et al. Early outcome of early-goal directed therapy for patients with sepsis or septic shock: a systematic review and meta-analysis of randomized controlled trials. Oncotarget. 2017 Apr 18;8(16):27510-27519. https://doi.org/10.18632/oncotarget.15550
  77. PRISM Investigators, Rowan KM, Angus DC, Bailey M, Barnato AE, et al. Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis. N Engl J Med. 2017 Jun;8;376(23):2223-2234. https://doi.org/10.1056/NEJMoa1701380
  78. Park SK, Shin SR, Hur M, Kim WH, et al. The effect of early goal-directed therapy for treatment of severe sepsis or septic shock: A systemic review and meta-analysis. J Crit Care. 2017 Apr;38:115-122. https://doi.org/10.1016/j.jcrc.2016.10.019
  79. Kalil AC, Johnson DW, Lisco SJ, Sun J. Early Goal-Directed Therapy for Sepsis: A Novel Solution for Discordant Survival Outcomes in Clinical Trials. Crit Care Med. 2017 Apr;45(4):607-614. https://doi.org/10.1097/CCM.0000000000002235
  80. Coccolini F, Sartelli M, Catena F, Ceresoli M, Montori G, Ansaloni L. Early goal-directed treatment versus standard care in management of early septic shock: Meta-analysis of randomized trials. J Trauma Acute Care Surg. 2016 Nov;81(5):971-978. https://doi.org/10.1097/TA.0000000000001246
  81. Liu B, Ding X, Yang J. Effect of early goal directed therapy in the treatment of severe sepsis and/or septic shock. Curr Med Res Opin. 2016 Nov;32(11):1773-1782. https://doi.org/10.1080/03007995.2016.1206872
  82. Lu J, Wang X, Chen Q, Chen M, Cheng L, Dai L, Jiang H, Sun Z. The effect of early goal-directed therapy on mortality in patients with severe sepsis and septic shock: a meta-analysis. J Surg Res. 2016 May 15;202(2):389-397. https://doi.org/10.1016/j.jss.2015.12.048
  83. Xu JY, Chen QH, Liu SQ, Pan C, et al.The Effect of Early Goal-Directed Therapy on Outcome in Adult Severe Sepsis and Septic Shock Patients: A Meta-Analysis of Randomized Clinical Trials. Anesth Analg. 2016 Aug;123(2):371-381. https://doi.org/10.1213/ANE.0000000000001278
  84. Pruinelli L, Westra BL, Yadav P, Hoff A, et al. Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock. Crit Care Med. 2018 Apr;46(4):500-505. https://doi.org/10.1097/CCM.0000000000002949
  85. Johnston ANB, Park J, Doi SA, Sharman V, et al. Effect of Immediate Administration of Antibiotics in Patients With Sepsis in Tertiary Care: A Systematic Review and Meta-analysis. Clin Ther. 2017 Jan;39(1):190-202.e6. https://doi.org/10.1016/j.clinthera.2016.12.003
  86. Whiles BB, Deis AS, Simpson SQ. Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients. Crit Care Med. 2017 Apr;45(4):623-629. https://doi.org/10.1097/CCM.0000000000002262
  87. Sungkar Y, Considine J, Hutchinson A. Implementation of guidelines for sepsis management in emergency departments: A systematic review. Australas Emerg Care. 2018 Nov;21(4):111-120. https://doi.org/10.1016/j.auec.2018.10.003
  88. Kumar A, Roberts D, Wood KE, Light B, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 2006;34:1589-1596. https://doi.org/10.1097/01.CCM.0000217961.75225.E9
  89. Kalil AC, Johnson DW, Lisco SJ, Sun J. Early Goal-Directed Therapy for Sepsis: A Novel Solution for Discordant Survival Outcomes in Clinical Trials. Crit Care Med. 2017 Apr;45(4):607-614. https://doi.org/10.1097/CCM.0000000000002235
  90. Seymour CW, Kahn JM, Martin-Gill C, Callaway CW, et al. Delays From First Medical Contact to Antibiotic Administration for Sepsis. Crit Care Med. 2017 Feb;23. https://doi.org/10.1097/CCM.0000000000002264
  91. Zhou X, Su LX, Zhang JH, Liu DW, Long Y. Rules of anti-infection therapy for sepsis and septic shock. Chin Med J (Engl). 2019 Mar 5;132(5):589-596. https://doi.org/10.1097/CM9.0000000000000101
  92. Seymour CW, Kennedy JN, Wang S, Chang CH, et al. Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. JAMA. 2019 May;28;321(20):2003-2017. https://doi.org/10.1001/jama.2019.5791
  93. Liu VX, Fielding-Singh V, Greene JD, Baker JM, et al. The Timing of Early Antibiotics and Hospital Mortality in Sepsis. Am J Respir Crit Care Med. 2017 Oct;1;196(7):856-863. https://doi.org/10.1164/rccm.201609-1848OC
  94. Johnston ANB, Park J, Doi SA, Sharman V, et al. Effect of Immediate Administration of Antibiotics in Patients With Sepsis in Tertiary Care: A Systematic Review and Meta-analysis. Clin Ther. 2017 Jan;39(1):190-202.e6. https://doi.org/10.1016/j.clinthera
  95. Guo Y, Gao W, Yang H, Ma C, Sui S. De-escalation of empiric antibiotics in patients with severe sepsis or septic shock: A meta-analysis. Heart Lung. 2016 Sep-Oct;45(5):454-459. https://doi.org/10.1016/j.hrtlng.2016.06.001
  96. Sawyer RG, Claridge JA, Nathens AB, Rotstein OD, et. al. STOP-IT Trial Investigators. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med. 2015 May;21;372(21):1996-2005. https://doi.org/10.1056/NEJMoa1411162
  97. Pepper DJ, Sun J, Cui X, Welsh J, et al. Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service’s Sepsis Bundle (SEP-1). Crit Care Med. 2019 Jul;31. https://doi.org/10.1097/CCM.0000000000003892
  98. Programma SKAT (Strategiya Kontrolya antimikrobnoi terapii pri okazanii statsionarnoi meditsinskoi pomoshchi). Rossiiskie klinicheskie rekomendatsii. Moskva; 2017. 131 c.
  99. Lewis SR, Pritchard MW, Evans DJ, Butler AR, et al. Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database Syst Rev. 2018 Aug;3;8:CD000567. https://doi.org/10.1002/14651858.CD000567.
  100. Jiang L, Jiang S, Zhang M, Zheng Z, Ma Y. Albumin versus other fluids for fluid resuscitation in patients with sepsis: a meta-analysis. PLoS One. 2014 Dec;4;9(12):e114666. https://doi.org/10.1371/journal.pone.0114666
  101. Rochwerg B, Alhazzani W, Sindi A, Heels-Ansdell D, et al. Fluids in Sepsis and Septic Shock Group. Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med. 2014 Sep;2;161(5):347-355. https://doi.org/10.7326/M14-0178
  102. Allen JM, Feild C, Shoulders BR, Voils SA. Recent Updates in the Pharmacological Management of Sepsis and Septic Shock: A Systematic Review Focused on Fluid Resuscitation, Vasopressors, and Corticosteroids. Ann Pharmacother. 2019 Apr;53(4):385-395. https://doi.org/10.1177/1060028018812940
  103. Lu Y, Zhang H, Teng F, Xia WJ, et al. Early Goal-Directed Therapy in Severe Sepsis and Septic Shock: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. J Intensive Care Med. 2018 May;33(5):296-309. https://doi.org/10.1177/0885066616671710
  104. Silversides JA, Major E, Ferguson AJ, Mann EE, et al. Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis. Intensive Care Med. 2017 Feb;43(2):155-170. https://doi.org/10.1007/s00134-016-4573-3
  105. Hammond DA, Lam SW, Rech MA, Smith MN, et al. Balanced Crystalloids Versus Saline in Critically Ill Adults: A Systematic Review and Meta-analysis. Ann Pharmacother. 2019 Jul;31:1060028019866420. https://doi.org/10.1177/1060028019866420
  106. Serpa Neto A, Veelo DP, Peireira VG, de Assunção MS, et al. Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review and meta-analysis of the literature. J Crit Care. 2014 Feb;29(1):185.e1-7. https://doi.org/10.1016/j.jcrc.2013.09.031
  107. Allen JM, Feild C, Shoulders BR, Voils SA. Recent Updates in the Pharmacological Management of Sepsis and Septic Shock: A Systematic Review Focused on Fluid Resuscitation, Vasopressors, and Corticosteroids. Ann Pharmacother. 2019 Apr;53(4):385-395. https://doi.org/10.1177/1060028018812940
  108. Belletti A, Benedetto U, Biondi-Zoccai G, Leggieri C, et al. The effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials. J Crit Care. 2017 Feb;37:91-98. https://doi.org/10.1016/j.jcrc.2016.08.010
  109. Gamper G, Havel C, Arrich J, Losert H, et al. Vasopressors for hypotensive shock. Cochrane Database Syst Rev. 2016 Feb;15;2:CD003709. https://doi.org/10.1002/14651858.CD003709
  110. Avni T, Lador A, Lev S, Leibovici L, et al. Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 3;10(8):e0129305. https://doi.org/10.1371/journal.pone.0129305
  111. Zhou F, Mao Z, Zeng X, Kang H, et al. Vasopressors in septic shock: a systematic review and network meta-analysis. Ther Clin Risk Manag. 2015 Jul;14;11:1047-1059. https://doi.org/10.2147/TCRM.S80060
  112. Bai X, Yu W, Ji W, et al. Early versus delayed administration of norepinephrine in patients with septic shock. Crit Care. 2014 Oct;3;18(5):532. https://doi.org/10.1186/s13054-014-0532-y
  113. Fang F, Zhang Y, Tang J, Lunsford LD, et al. Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis. JAMA Intern Med. 2019 Feb;1;179(2):213-223. https://doi.org/10.1001/jamainternmed.2018.5849
  114. Rochwerg B, Oczkowski SJ, Siemieniuk RAC, Agoritsas T, et al. Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis. Crit Care Med. 2018 Sep;46(9):1411-1420. https://doi.org/10.1097/CCM.0000000000003262
  115. Xu R, Wang Q, Huang Y, Wu L, et al. Do low-dose corticosteroids improve survival or shock reversal from septic shock in adults? Meta-analysis with trial sequential analysis. J Int Med Res. 2018 Jul;46(7):2513-2524. https://doi.org/10.1177/0300060518774985
  116. Rygård SL, Butler E, Granholm A, Møller MH, et al. Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Med. 2018 Jul;44(7):1003-1016. https://doi.org/10.1007/s00134-018-5197-6
  117. Gibbison B, López-López JA, Higgins JP, Miller T, Angelini GD, Lightman SL, Annane D. Corticosteroids in septic shock: a systematic review and network meta-analysis. Crit Care. 2017 Mar:28;21(1):78. https://doi.org/10.1186/s13054-017-1659-4
  118. Yao YY, Lin LL, Gu HY, Wu JY, et al. Are Corticosteroids Beneficial for Sepsis and Septic Shock? Based on Pooling Analysis of 16 Studies. Front Pharmacol. 2019 Jul;12;10:714. https://doi.org/10.3389/fphar.2019.00714
  119. Arias J, Levy B, De Backer D. Fifty Years of Management of Vasodilatory Shock. Int Anesthesiol Clin. 2019 Spring;57(2):31-47. https://doi.org/10.1097/AIA.0000000000000226
  120. Yu L, Sun R. Evaluation and treatment of sepsis-induced myocardial dysfunction: a systematic study. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Mar;31(3):378-380. https://doi.org/10.3760/cma.j.issn.2095-4352.2019.03.025
  121. Stratton L, Berlin DA, Arbo JE. Vasopressors and Inotropes in Sepsis. Emerg Med Clin North Am. 2017 Feb;35(1):75-91. https://doi.org/10.1016/j.emc.2016.09.005
  122. Pinto-Lopes R, Sousa-Pinto B, Azevedo LF. Single dose versus multiple dose of antibiotic prophylaxis in caesarean section: a systematic review and meta-analysis. BJOG. 2017 Mar;124(4):595-605. https://doi.org/10.1111/1471-0528.14373
  123. Bollig C, Nothacker M, Lehane C, Motschall E, et al. Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review. Acta Obstet Gynecol Scand. 2018 May;97(5):521-535. https://doi.org/10.1111/aogs.13276
  124. Zhang C, Zhang L, Liu X, Zhang L, et al. Timing of Antibiotic Prophylaxis in Elective Caesarean Delivery: A Multi-Center Randomized Controlled Trial and Meta-Analysis. PLoS One. 2015 Jul 6;10(7):e0129434. https://doi.org/10.1371/journal.pone.0129434
  125. Martin EK, Beckmann MM, Barnsbee LN, Halton KA, et al. Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta-analyses. BJOG. 2018 Jul;125(8):956-964. https://doi.org/10.1111/1471-0528.15125
  126. Shea SK, Soper DE. Prevention of Cesarean Delivery Surgical Site Infections. Obstet Gynecol Surv. 2019 Feb;74(2):99-110. https://doi.org/10.1097/OGX.0000000000000645
  127. Van Schalkwyk J, Van Eyk N. No. 247-Antibiotic Prophylaxis in Obstetric Procedures. J Obstet Gynaecol Can. 2017 Sep;39(9):e293-e299. https://doi.org/10.1016/j.jogc.2017.06.007 WHO recommendations for prevention and treatment of maternal peripartum infections. 28-th of September 2015;70:44.
  128. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 199: Use of Prophylactic Antibiotics in Labor and Delivery. Obstet Gynecol. 2018 Sep;132(3):e103-e119. https://doi.org/10.1097/AOG.0000000000002833

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.