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Kurdyumova N.V.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Savin I.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Ershova O.N.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Aleksandrova I.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Sazykina S.Yu.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Gadjieva O.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Danilov G.V.

N.N. Burdenko National Medical Research Center of Neurosurgery under Ministry of Health of the Russi, 125047, Moscow, Russia

Shifrin M.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Fursova N.K.

State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia

Nosocomial meningitis caused by Acinetobacter baumannii in ICU patients

Authors:

Kurdyumova N.V., Savin I.A., Ershova O.N., Aleksandrova I.A., Sazykina S.Yu., Gadjieva O.A., Danilov G.V., Shifrin M.A., Fursova N.K.

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Journal: Russian Journal of Anesthesiology and Reanimatology. 2019;(4): 43‑49

DOI: 10.17116/anaesthesiology201904143

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To cite this article:

Kurdyumova NV, Savin IA, Ershova ON, et al. . Nosocomial meningitis caused by Acinetobacter baumannii in ICU patients. Russian Journal of Anesthesiology and Reanimatology. 2019;(4):43‑49. (In Russ.)
https://doi.org/10.17116/anaesthesiology201904143

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ABSTRACT Aim — to establish clinical features, predictors of unfavorable outcome, and analyze the treatment strategy for patients with nosocomial meningitis (NM) caused by A.baumannii (ABM) in ICU. Materials and methods. The results of CNS infections prospective surveillance in the intensive care unit (ICU) of the FSAI “NMRC for neurosurgery named after N.N. Burdenko” of the Ministry of Health of Russia during the 6-year period. Results. The overall incidence of NM was 9.45% [95% CI 8.25%-10.65%] for severe patients. In 33 patients with NM A. baumannii was obtained from CSF by microbilogical cultiring. The average proportion of A. baumannii among all NM causative agents was 22.1%. The average length of stay in the ICU was 48 days. Mortality in the group of patients with ABM was 48.4%. ABM manifested by pronounced inflammatory changes in CSF, fever, and impairment of consciousness. First line therapy with the maximum carbapenem dose was reasonable. Treatment could be more effective when antibiotics were injected into CSF additionally. Conclusion. Nosocomial meningitis caused by A. baumannii are associated with a high mortality rate and prolonged patient’s stay in the ICU. Pronounced inflammatory changes in CSF, fever, as well as impairment of consciousness are crucial in the diagnostics of ABM. The treatment is effective with maximum dose of intravenous carbapenems in combination with administration of antibiotics in CSF directly. ABM was associated with the high rate of A. baumannii resistance to carbapenems.

Keywords:

nosocomial meningitis
Acinetobacter baumannii
ICU
neurosurgery

Authors:

Kurdyumova N.V.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Savin I.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Ershova O.N.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Aleksandrova I.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Sazykina S.Yu.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Gadjieva O.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Danilov G.V.

N.N. Burdenko National Medical Research Center of Neurosurgery under Ministry of Health of the Russi, 125047, Moscow, Russia

Shifrin M.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Fursova N.K.

State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia

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