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Sivolap Yu.P.

Sechenov First Moscow State Medical University (Sechenov University)

Treatment of alcohol withdrawal syndrome

Authors:

Sivolap Yu.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6): 139‑144

DOI: 10.17116/jnevro2021121061139

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Table of contents

TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME
TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME

To cite this article:

Sivolap YuP. Treatment of alcohol withdrawal syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6):139‑144. (In Russ.)
https://doi.org/10.17116/jnevro2021121061139

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
A pilot study of asso­ciations of markers of glial and neuronal dege­neration with executive functions in alco­hol use diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):74-79
Abstract:

Alcohol withdrawal arises in result of long-lasting or short, but massive, alcohol abuse, manifests itself with oppressive symptoms and in some cases is complicated by seizures, hallucinosis and delirium tremens that may be life-threatening for patients. The leading neurochemical factors underlying alcohol withdrawal syndrome and its complications are lack of GABA and excessive glutamate activity, which is important for therapy choice. The first-line drugs in the treatment of alcohol withdrawal syndrome and alcoholic delirium are benzodiazepines, which have the maximum pharmacological similarity with ethanol. Other medications, including barbiturates, anticonvulsants, propofol, dexmedetomidine, and antipsychotics, may be used as alternatives to and in addition to benzodiazepines, especially in the case of protracted delirium with therapeutic resistance. Certain prospects in the treatment of alcohol withdrawal syndrome are associated with ethylmethylhydroxypyridine succinate, which is a bit similar to benzodiazepines in its pharmacology.

Keywords:

alcohol use disorders
alcohol withdrawal syndrome
alcohol seizures
alcohol hallucinosis
delirium tremens
benzodiazepines

Authors:

Sivolap Yu.P.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

23.04.2021

Accepted:

07.05.2021

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References:

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