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Kirilochev O.O.

Astrakhan State Medical University, Astrakhan, Russia;
Astrakhan Regional Clinical Psychiatric Hospital, Astrakhan, Russia

Umerova A.R.

Astrakhan State Medical University, Astrakhan, Russia

Dorfman I.P.

Astrakhan State Medical University, Astrakhan, Russia

Khryashchev A.V.

Astrakhan State Medical University, Astrakhan, Russia;
Astrakhan Regional Clinical Psychiatric Hospital, Astrakhan, Russia

The drug-drug interactions in a psychiatric hospital

Authors:

Kirilochev O.O., Umerova A.R., Dorfman I.P., Khryashchev A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5): 26‑30

DOI: 10.17116/jnevro20171175126-30

Views: 3026

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To cite this article:

Kirilochev OO, Umerova AR, Dorfman IP, Khryashchev AV. The drug-drug interactions in a psychiatric hospital. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5):26‑30. (In Russ.)
https://doi.org/10.17116/jnevro20171175126-30

 
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An analysis of 132 drugs used in a psychiatric hospital for the estimation of the possibility of drug-drug interactions has been carried out. It has been established that one in five potential combination has a drug-drug interaction with clinically significant interactions being more frequent. Psychotropic drugs occupy a leading position in the number of such interactions. This analysis is able to improve the safety of the combined pharmacotherapies by choosing an alternative drug, correction of dose or active monitoring of the clinical condition of the patient, including laboratory and instrumental data.

Keywords:

combined pharmacotherapies
drug-drug interactions
adverse drug reactions

Authors:

Kirilochev O.O.

Astrakhan State Medical University, Astrakhan, Russia;
Astrakhan Regional Clinical Psychiatric Hospital, Astrakhan, Russia

Umerova A.R.

Astrakhan State Medical University, Astrakhan, Russia

Dorfman I.P.

Astrakhan State Medical University, Astrakhan, Russia

Khryashchev A.V.

Astrakhan State Medical University, Astrakhan, Russia;
Astrakhan Regional Clinical Psychiatric Hospital, Astrakhan, Russia

List of references:

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  2. Längle G, Steinert T, Weiser P, Schepp W, Jaeger S, Pfiffner C, Frasch K, Eschweiler GW, Messer T, Croissant D, Becker T, Kilian R. Effects of polypharmacy on outcome in patients with schizophrenia in routine psychiatric treatment. Acta Psychiatrica Scandinavica. 2012;125(5):372-381. doi:10.1111/j.1600-0447.2012.01835.x
  3. Sychev D, Otdelenov V, Danilina K, Anikin G, Arslanbekova S. Drug interactions and polypragmasy in a physician’s practice. Vrach. 2013;5:5-9. (In Russ.).
  4. Sychev DA, Otdelenov VA. Drug—drug interactions in the practice of an internist: The opinion of a clinical pharmacologist. Spravochnik Poliklinicheskogo Vracha. 2014;12:18-21. (In Russ.).
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  10. Teixeira JJ, Crozatti MT, dos Santos CA, Romano-Lieber NS. Potential drug-drug interactions in prescriptions to patients over 45 years of age in primary care, southern Brazil. PLoS One. 2012;7(10):47062. doi:10.1371/journal.pone.0047062
  11. Laursen TM, Munk-Olsen T, Vestergaard M. Life expectancy and cardiovascular mortality in persons with schizophrenia. Current Opinion in Psychiatry. 2012;25(2):83-88. doi:10.1097/YCO.0b013e32835035ca
  12. Magro L, Moretti U, Leone R. Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions. Expert Opinion on Drug Safety. 2012;11(1):83-94. doi:10.1517/14740338.2012.631910
  13. Murtaza G, Khan MY, Azhar S, Khan SA, Khan TM. Assessment of potential drug-drug interactions and its associated factors in the hospitalized cardiac patients. Saudi Pharmaceutical Journal. 2016;24(2):220-225. doi:10.1016/j.jsps.2015.03.009
  14. Oertle M. Frequency and nature of drug-drug interactions in a Swiss primary and secondary acute care hospital. Swiss Medical Weekly. 2012;142:13522. doi:10.4414/smw.2012.13522
  15. URL: http://www.drugs.com/drug_interactions.php Access date: 01.10.2016.

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