We examined 72 patients with headache of tension (HAT), 56 women and 16 men, aged from 18 to 45 years (mean age 32,7±8,5 years). Frequent HAT was diagnosed in 48 cases and chronic HAT - in 24 cases. Clinical-psychological and electroencephalographic study was conducted before and after the treatment with adaptol. The results were compared to those of the control group. This group included 30 patients treated with alprazolam. Two clinical variants of the disease were singled out: asthenic (25 patients) and anxiety (47 patients). The correctness of the identification was confirmed by electroencephalographic data. The higher efficacy of adaptol was noted in frequent HAT. During the treatment, there was the reduction of severity of cephalgia syndrome and of anxiety and asthenic scores as well, while depression scores did not change. Adaptol was more effective compared to alprazolam.