The influence of gel-like recombinant interferon -2b on the clinical course of acute respiratory infection and the state of mucosal immunity in the pregnant women

Meshcheriakova A.K.

Laboratoriia vaktsinoprofilaktiki i immunoterapii allergicheskikh zabolevaniĭ NIIVS im. I.I. Mechnikova RAMN, Moskva, Rossiia, 105064

Kostinov M.P.

Laboratoriia vaktsinoprofilaktiki i immunoterapii allergicheskikh zabolevaniĭ NII vaktsin i syvorotok im. I.I. Mechnikova RAMN, Moskva

Magarshak O.O.

Laboratoriia vaktsinoprofilaktiki i immunoterapii allergicheskikh zabolevaniĭ NIIVS im. I.I. Mechnikova RAMN, Moskva, Rossiia, 105064

Guseva T.S.

NII pidemiologii i mikrobiologii im. N.F. Gamalei Minzdrava RF, Moskva, Rossiia, 123098

Parshina O.V.

NII pidemiologii i mikrobiologii im. N.F. Gamalei Minzdrava RF, Moskva, Rossiia, 123098

The influence of gel-like recombinant interferon -2b on the clinical course of acute respiratory infection and the state of mucosal immunity in the pregnant women

Authors:

Meshcheriakova A.K., Kostinov M.P., Magarshak O.O., Guseva T.S., Parshina O.V.

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Journal: Russian Bulletin of Otorhinolaryngology. 2014;(6): 50‑53

DOI: 10.17116/otorino2014650-53

Downloaded: 19

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To cite this article:

Meshcheriakova AK, Kostinov MP, Magarshak OO, Guseva TS, Parshina OV. The influence of gel-like recombinant interferon -2b on the clinical course of acute respiratory infection and the state of mucosal immunity in the pregnant women. Russian Bulletin of Otorhinolaryngology. 2014;(6):50‑53. (In Russ.)
https://doi.org/10.17116/otorino2014650-53

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)

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The objective of the present study was to evaluate the state of local immunity of the mucous membrane in the nose of the pregnant women presenting with acute respiratory infection (ARI). A total of 55 women with this condition were examined at the outpatient basis starting from week 14 of the gestation period. Viferon gel was administered intranasally to 34 such patients. The clinical and immunological effectiveness of the application of the topical form of this recombinant interferon -2b preparation in these patients was evaluated. It is concluded that the inclusion of Viferon in the combined treatment of ARI in the pregnant women significantly decreases the frequency of bacterial complications. Simultaneously, this preparation reduces the IL-8 level in the nasal secretion in comparison with its initial value.

Keywords:

pregnant women

mucosal immunity

interferon -2b

Authors:

Meshcheriakova A.K.

Laboratoriia vaktsinoprofilaktiki i immunoterapii allergicheskikh zabolevaniĭ NIIVS im. I.I. Mechnikova RAMN, Moskva, Rossiia, 105064

Kostinov M.P.

Laboratoriia vaktsinoprofilaktiki i immunoterapii allergicheskikh zabolevaniĭ NII vaktsin i syvorotok im. I.I. Mechnikova RAMN, Moskva

Magarshak O.O.

Laboratoriia vaktsinoprofilaktiki i immunoterapii allergicheskikh zabolevaniĭ NIIVS im. I.I. Mechnikova RAMN, Moskva, Rossiia, 105064

Guseva T.S.

NII pidemiologii i mikrobiologii im. N.F. Gamalei Minzdrava RF, Moskva, Rossiia, 123098

Parshina O.V.

NII pidemiologii i mikrobiologii im. N.F. Gamalei Minzdrava RF, Moskva, Rossiia, 123098

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