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Tarakanova O.V.

City Clinical Oncology Hospital One Moscow Healthcare Department

Slavnova E.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Cytological diagnosis of salivary gland tumors

Authors:

Tarakanova O.V., Slavnova E.N.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2022;11(5): 78‑88

DOI: 10.17116/onkolog20221105178

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Table of contents

CYTOLOGICAL DIAGNOSIS OF SALIVARY GLAND TUMORS
CYTOLOGICAL DIAGNOSIS OF SALIVARY GLAND TUMORS

To cite this article:

Tarakanova OV, Slavnova EN. Cytological diagnosis of salivary gland tumors. P.A. Herzen Journal of Oncology. 2022;11(5):78‑88. (In Russ.)
https://doi.org/10.17116/onkolog20221105178

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Relying on literature data, the authors illuminate the current approaches to the cytological diagnosis of salivary gland tumors, which are based on the 2017 Milan classification. The latter identifies 6 diagnostic categories that cover a wide range of non-neoplastic and neoplastic diseases of this localization. The proposed classification not only contains cytological differential diagnostic criteria for various salivary gland tumor and non-tumor diseases, but also, on the strength of literature data, correlates the diagnostic categories with the risk of malignancy and the clinical standards for the treatment of patients.

Keywords:

fine-needle aspiration biopsy of the salivary glands
non-neoplastic diseases of the salivary glands
benign salivary gland tumors
salivary gland tumors of uncertain malignant
malignant salivary gland tumors

Authors:

Tarakanova O.V.

City Clinical Oncology Hospital One Moscow Healthcare Department

Slavnova E.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Received:

08.02.2022

Accepted:

18.02.2022

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References:

  1. Colella G, Cannavale R, Flamminio F, Foschini MP. Fine-needle aspiration cytology of salivary gland lesions: a systematic review. J Oral Maxillofac Surg. 2010;68(9):2146-2153. https://doi.org/10.1016/j.joms.2009.09.064
  2. Griffith CC, Pai RK, Schneider F, Duvvuri U, Ferris RL, Johnson JT, Seethala RR. Salivary gland tumor fine-needle aspiration cytology: a proposal for a risk stratification classification. Am J Clin Pathol. 2015;143(6):839-853.  https://doi.org/10.1309/AJCPMII6OSD2HSJA
  3. Liu CC, Jethwa AR, Khariwala SS, Johnson J, Shin JJ. Sensitivity, specificity, and posttest probability of parotid fine-needle aspiration: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2016;154(1):9-23.  https://doi.org/10.1177/0194599815607841
  4. Rossi ED, Wong LQ, Bizzarro T, Petrone G, Mule A, Fadda G, Baloch ZM. The impact of FNAC in the management of salivary gland lesions: institutional experiences leading to a risk-based classification scheme. Cancer Cytopathol. 2016;124(6):388-396.  https://doi.org/10.1002/cncy.21710
  5. Eom HJ, Lee JH, Ko MS, Choi YJ, Yoon RG, Cho KJ, Nam SY, Baek JH. Comparison of fine-needle aspiration and core needle biopsy under ultrasonographic guidance for detecting malignancy and for the tissue-specific diagnosis of salivary gland tumors. AJNR Am J Neuroradiol. 2015;36(6):1188-1193. https://doi.org/10.3174/ajnr.A4247
  6. Mairembam P, Jay A, Beale T, Morley S, Vaz F, Kalavrezos N, Kocjan G. Salivary gland FNA cytology: role as a triage tool and an approach to pitfalls in cytomorphology. Cytopathology. 2016;27(2):91-96.  https://doi.org/10.1111/cyt.12232
  7. Rossi ED, Faquin WC, Baloch Z, Barkan GA, Foschini MP, Pusztaszeri M, Vielh P, Kurtycz DFI. The Milan System for Reporting Salivary Gland Cytopathology: analysis and suggestions of initial survey. Cancer Cytopathol. 2017;125(10):757-766.  https://doi.org/10.1002/cncy.21898
  8. Wei S, Layfield LJ, LiVolsi VA, Montone KT, Baloch ZW. Reporting of fine needle aspiration (FNA) specimens of salivary gland lesions: a comprehensive review. Diagn Cytopathol. 2017;45(9):820-827.  https://doi.org/10.1002/dc.23716
  9. Ali SZ, Cibas ED, eds. The Bethesda system for reporting thyroid cytopathology. Definitions, criteria and explanatory notes. New York: Springer Science + Business Media, LLC; 2010. https://doi.org/10.1007/978-0-387-87666-5
  10. Pastore A, Borin M, Malagutti N, Di Laora A, Beccati D, Delazer AL, Bianchini C, Stomeo F, Ciorba A, Pelucchi S. Preoperative assessment of salivary gland neoplasms with fine needle aspiration cytology and echography: a retrospective analysis of 357 cases. Int J Immunopathol Pharmacol. 2013;26(4):965-971.  https://doi.org/10.1177/039463201302600416
  11. Droese M. Cytological diagnosis of sialadenosis, sialadenitis, and parotid cysts by fine-needle aspiration biopsy. Adv Otorhinolaryngol. 1981;26:49-96.  https://doi.org/10.1159/000395290
  12. Eveson JW, Nagao T. Diseases of the salivary glands. Ch. 10. In: Barnes L, ed. Surgical pathology of the head and neck. Vol. 1. 3rd ed. New York: Informa Healthcare; 2009;475-648. 
  13. Stanley MW, Bardales RH, Beneke J, Korourian S, Stern SJ. Sialolithiasis. Differential diagnostic problems in fine-needle aspiration cytology. Am J Clin Pathol. 1996;106(2):229-233.  https://doi.org/10.1093/ajcp/106.2.229
  14. Bhatti RM, Stelow EB. IgG4-related disease of the head and neck. Adv Anat Pathol. 2013;20(1):10-16.  https://doi.org/10.1097/PAP.0b013e31827b619e
  15. Nasuti JF, Gupta PK, Fleisher SR, LiVolsi VA. Nontyrosine crystalloids in salivary gland lesions: report of seven cases with fine-needle aspiration cytology and follow-up surgical pathology. Diagn Cytopathol. 2000;22(3):167-171. https://doi.org/10.1002/(sici)1097-0339(20000301)22:3<167::aid-dc7>3.0.co;2-p "> 3.0.co;2-p" target="_blank">https://doi.org/10.1002/(sici)1097-0339(20000301)22:3<167::aid-dc7>3.0.co;2-p
  16. Pantanowitz L, Goulart RA, Cao QJ. Salivary gland crystalloids. Diagn Cytopathol. 2006;34(11):749-750.  https://doi.org/10.1002/dc.20539
  17. Michelow P, Dezube BJ, Pantanowitz L. Fine needle aspiration of salivary gland masses in HIV-infected patients. Diagn Cytopathol. 2012;40(8):684-690.  https://doi.org/10.1002/dc.21597
  18. Rooper LM, Onenerk M, Siddiqui MT, Faquin WC, Bishop JA, Ali SZ. Nodular oncocytic hyperplasia: can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease? Cancer Cytopathol. 2017;125(8):627-634.  https://doi.org/10.1002/cncy.21865
  19. Allison DB, McCuiston AM, Kawamoto S, Eisele DW, Bishop JA, Maleki Z. Cystic major salivary gland lesions: utilizing fine needle aspiration to optimize the clinical management of a broad and diverse differential diagnosis. Diagn Cytopathol. 2017;45(9):800-807.  https://doi.org/10.1002/dc.23780
  20. Zerpa VZ, Gonzales MTC, Porras GA, Acuna MM, Ferriol EE, Galofre JD. Precisión diagnóstica de la citología por punción aspiración con aguja fina en tumores de la glándula parótida. [Diagnostic accuracy of fine needle aspiration cytology in parotid tumours]. Acta Otorrinolaringol Esp. 2014;65(3):157-161.  https://doi.org/10.1016/j.otorri.2013.12.002
  21. El-Naggar AK, JKC C, Grandis JR, Takata T, Slootweg PJ, eds. WHO classification of head and neck tumours. WHO classification of tumours. Vol. 9. 4th ed. France, Lyon: World Health Organization. IARC publications; 2017.
  22. Brandwein MS, Huvos AG. Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 1991;15(6):514-528.  https://doi.org/10.1097/00000478-199106000-00002
  23. Wakely PE Jr. Oncocytic and oncocytic-like lesions of the head and neck. Ann Diagn Pathol. 2008;12(3):220-230.  https://doi.org/10.1016/j.anndiagpath.2008.04.007
  24. Walaas L, Kindblom LG. Lipomatous tumors: a correlative cytologic and histologic study of 27 tumors examined by fine needle aspiration cytology. Hum Pathol. 1985;16(1):6-18.  https://doi.org/10.1016/s0046-8177(85)80208-2
  25. Mooney EE, Layfield LJ, Dodd LG. Fine-needle aspiration of neural lesions. Diagn Cytopathol. 1999;20(1):1-5. https://doi.org/10.1002/(sici)1097-0339(199901)20:1<1::aid-dc1>3.0.co;2-j "> 3.0.co;2-j" target="_blank">https://doi.org/10.1002/(sici)1097-0339(199901)20:1<1::aid-dc1>3.0.co;2-j
  26. Tyagi R, Dey P. Diagnostic problems of salivary gland tumors. Diagn Cytopathol. 2015;43(6):495-509.  https://doi.org/10.1002/dc.23255
  27. Wang H, Fundakowski C, Khurana JS, Jhala N. Fine-needle aspiration biopsy of salivary gland lesions. Arch Pathol Lab Med. 2015;139(12):1491-1497. https://doi.org/10.5858/arpa.2015-0222-RA
  28. Vander Poorten V, Triantafyllou A, Thompson LDR, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, et al. Salivary acinic cell carcinoma: reappraisal and update. Eur Arch Otorhinolaryngol. 2016;273(11):3511-3531. https://doi.org/10.1007/s00405-015-3855-7
  29. Bishop JA, Yonescu R, Batista DAS, Westra WH, Ali SZ. Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathol. 2013;121(5):228-233.  https://doi.org/10.1002/cncy.21245
  30. Skalova A, Michal M, Simpson RH. Newly described salivary gland tumors. Mod Pathol. 2017;30(suppl 1):27-43.  https://doi.org/10.1038/modpathol.2016.167
  31. Bishop JA. Mammary analog secretory carcinoma of salivary glands: review of a new entity with an emphasis on differential diagnosis. Pathol Case Rev. 2015;20(1):7-12.  https://doi.org/10.1097/PCR.0000000000000073
  32. Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31(1):44-57.  https://doi.org/10.1097/01.pas.0000213314.74423.d8
  33. Kleinsasser O, Klein HJ, Hübner G. Speichelgangearcinome. Ein den Milchgangcarcinomen der Brustdrüse analoge Gruppe von Speichldrüsentumoren. [Salivary duct carcinoma. A group of salivary gland tumors analogous to mammary duct carcinoma]. Arch Klin Exp Ohren Nasen Kehlkopfheilkd. 1968;192(1):100-105. 
  34. Schneider M, Rizzardi C. Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions. Arch Pathol Lab Med. 2008;132(2):278-282.  https://doi.org/10.5858/2008-132-278-LCOTPG
  35. Hipp JA, Jing X, Zarka MA, Schmitt AC, Siddiqui MT, Wakely P Jr, Bishop J, Ali SZ. Cytomorphologic characteristics and differential diagnoses of lymphoepithelial carcinoma of the parotid. J Am Soc Cytopathol. 2016;5(2):93-99.  https://doi.org/10.1016/J.JASC.2015.09.216
  36. Seethala RR. An update on grading of salivary gland carcinomas. Head Neck Pathol. 2009;3(1):69-77.  https://doi.org/10.1007/s12105-009-0102-9
  37. Petersson F. High-grade transformation («dedifferentiation») — malignant progression of salivary gland neoplasms, including carcinoma ex pleomorphic adenoma: a review. Pathol Case Rev. 2015;20(1):27-37.  https://doi.org/10.1097/PCR.0000000000000076
  38. Nagao T. «Dedifferentiation» and high-grade transformation in salivary gland carcinomas. Head Neck Pathol. 2013;7(suppl 1):37-47.  https://doi.org/10.1007/s12105-013-0458-8
  39. Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Rinaldo A, Strojan P, Haigentz M Jr, Mendenhall WM, Takes RP, Vander Poorten V, Ferlito A. Salivary mucoepidermoid carcinoma revisited. Eur Arch Otorhinolaryngol. 2015;272(4):799-819.  https://doi.org/10.1007/s00405-014-3053-z
  40. Coca-Pelaz A, Rodrigo JP, Bradley PJ, Vander Poorten V, Triantafyllou A, Hunt JL, Strojan P, Rinaldo A, Haigentz M Jr, Takes RP, et al. Adenoid cystic carcinoma of the head and neck — an update. Oral Oncol. 2015;51(7):652-661.  https://doi.org/10.1016/j.oraloncology.2015.04.005
  41. Savera AT, Sloman A, Huvos AG, Klimstra DS. Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients. Am J Surg Pathol. 2000;24(6):761-774.  https://doi.org/10.1097/00000478-200006000-00001
  42. Chute DJ, Stelow EB. Cytology of head and neck squamous cell carcinoma variants. Diagn Cytopathol. 2010;38(1):65-80.  https://doi.org/10.1002/dc.21134
  43. Wang H, Hoda RS, Faquin W, Rossi ED, Hotchandani N, Sun T, Pusztaszeri M, Bizzarro T, Bongiovanni M, Patel V, et al. FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: a multi-institutional study of 184 cases. Cancer Cytopathol. 2017;125(2):91-103.  https://doi.org/10.1002/cncy.21798
  44. Soft tissue tumors — basic information, Ch. 1. In: Ekerman M, Domanski HA. The cytology of soft tissue tumours. Monographs in clinical cytology. vol. 16. Basel: Karger; 2003;1.  https://doi.org/10.1159/000073149
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