Radiobiological models and clinical radiation oncology

Stolbovoy A.V.; Zalyalov I.F.

doi:https://doi.org/10.17116/onkolog20165688-96

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Abstract:

The paper presents basic radiobiological models in radiation oncology as the theories that predict the effect in normal tissues and in tumors during their ionizing radiation. It shows their mathematical basis leaning upon an event in a certain cell, as well as they are applied to the practice of radiation therapy to calculate the dose of radiation and the number of fractions per treatment cycle in order to adjust the dose sufficient for tumor destruction, by preserving the viability or physiological function of normal tissues and organs. The paper considers how the radiobiological models allow one to compare the biological effect of irradiation in a variety of dose adjustment over time, i.e. during different fractionation modes and how they are used to represent physical quantities (e.g. an absorbed dose) as clinical indicators, such as a biologically effective dose, tumor control probability, and normal tissue complication probability, which are used to optimize radiation plans. It gives the history of radiobiological models and the current view on their role in the practice of radiotherapy.

Keywords:

radiobiological model

time—dose—fractionation factor

biologically effective dose

tumor control probability

normal tissue complication probability

Authors:

Stolbovoy A.V.

Department of Radiology, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow, Russia

Zalyalov I.F.

Department of Radiology, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow, Russia

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References:

Grubbé E. Priority in the therapeutic use of X-rays. Radiology. 1933;21(2):156-162. doi:10.1148/21.2.156
Foray N. Victor Despeignes (1866—1937): how a hygienist became the first radiation oncologist. Cancer Radiothér. 2013;17(3):244-254. doi:10.1016/j.canrad.2013.01.012
Wang C. The progress of radiobiological models in modern radiotherapy with emphasis on the uncertainty issue. Mutat Res. 2010;704(1-3):175-181. doi:10.1016/j.mrrev.2010.02.001
Ternovoi S. Fundamentals of radiation diagnosis and therapy. National leadership [Osnovy luchevoi diagnostiki i terapii. Natsional'noe rukovodstvo]. Moscow: GEOTAR-Media; 2012. (In Russ.)
Gunderson L, Tepper J, Bogart J. Clinical radiation oncology. Philadelphia, Pa.: Saunders/Elsevier; 2012.
Ellis F. Nominal standard dose and the ret. Br J Radiol. 1971;44(518):101-108. doi:10.1259/0007-1285-44-518-101
Klimanov V. Radiobiological and dosimetric planning of radiation and radionuclide therapy [Radiobiologicheskoe i dozimetricheskoe planirovanie luchevoi i radionuklidnoi terapii]. Part 1. Uchebnoe posobie. Moscow: NIYaU MIFI; 2011. (In Russ.)
Trufanov G. Radiation therapy. Textbook [Luchevaya terapiya. Uchebnik]. Moscow: GEOTAR-Media; 2012. (In Russ.)
Orton C. Errors in applying the NSD concept. Radiology. 1975;115(1):233-235. doi:10.1148/115.1.233
Ruderman A, Vainberg M, Zholkiver K. Remote gamma therapy of malignant tumors [Distantsionnaya gamma-terapiya zlokachestvennykh opukholei]. Moscow: Meditsina; 1977. (In Russ.)
Thames H, Bentzen S, Turesson I, Overgaard M, Van den Bogaert W. Time-dose factors in radiotherapy: a review of the human data. Radiother Oncol. 1990;19(3):219-235. doi:10.1016/0167-8140(90)90149-q
van Luijk P, Bijl H, Konings A, Kogel A, Schippers J. Data on dose-volume effects in the rat spinal cord do not support existing NTCP models. Int J Radiat Oncol Biol Phys. 2005;61(3):892-900. doi:10.1016/j.ijrobp.2004.10.035
Rafla S, Abachi F. A quantitative comparative study of radiation damage in normal tissues and squamous cell carcinoma (A critical look at NSD). Int J Radiat Oncol Biol Phys. 1978;4:232-233. doi:10.1016/0360-3016(78)90447-9
Orton C, Ellis F. A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol. 1973;46(547):529-537. doi:10.1259/0007-1285-46-547-529
Fadeeva M, Kostromina K, Datsenko V. Factors-time dose fractionation and their use in radiation therapy of malignant tumors. Guidelines [Faktory vremya-doza-fraktsionirovanie i ikh ispol'zovanie v luchevoi terapii zlokachestvennykh opukholei. Metodicheskie rekomendatsii]. Moscow: MZ SSSR; 1990. (In Russ.)
Prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT): contents. J ICRU. 2010;10(1):NP. doi:10.1093/jicru/ndq002
Koga S. A brief introduction of ICRP publication 44: Protection of the patient in radiation therapy. Jpn J Health Phys. 1985;20(4):417-422. doi:10.5453/jhps.20.417
Lindenbraten L, Korolyuk I. Nuclear medicine [Meditsinskaya radiologiya]. 2nd ed. Moscow: Meditsina; 2000. (In Russ.)
Withers H, Taylor J, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 1988;27(2):131-146. doi:10.3109/02841868809090333
Khan F. Treatment planning in radiation oncology. Philadelphia: Lippincott Williams & Wilkins; 2007.
Yarmonenko S, Vainson A. Radiobiology of humans and animals [Radiobiologiya cheloveka i zhivotnykh]. Moscow: Vysshaya shkola; 2004. (In Russ.)
Chadwick K, Leenhouts H. The molecular theory of radiation biology. Berlin, Heidelberg: Springer-Verlag; 1981.
Beyzadeoglu M, Ozyigit G, Ebruli C. Basic radiation oncology. Dordrecht: Springer; 2010.
Ballarini F. From DNA radiation damage to cell death: theoretical approaches. J Nucleic Acids. 2010;2010:350608. doi:10.4061/2010/350608
Radiation Oncology/Radiobiology/Basic Radiobiology — Wikibooks, open books for an open world. Enwikibooksorg. Accessed: March 6, 2016. Available at: http://en.wikibooks.org/wiki/Radiation_Oncology/Radiobiology/Basic_Radiobiolo-gy
Tsujii H, Kamada T, Shirai T, Noda K, Tsuji H, Karasawa K, eds. Carbo-ion radiotherapy. Tokyo, Heidelberg, New York, Dordrecht, London: Springer; 2014.
Astroorg. Accessed March 6, 2016. Available at: https://www.astro.org/AudioUpload/Updated7.Radiobiology-behind-Dose-Fractionation_ATB.ppt
Brenner D, Sachs R, Peters L, Withers H, Hall E. We forget at our peril the lessons built into the α/β model. Int J Radiat Oncol Biol Phys. 2012;82(4):1312-1314. doi:10.1016/j.ijrobp.2011.12.045
Pavlov A. Linear-quadratic model calculations isoefficiency doses, and evaluating the antitumor effect of radiation reactions and complications of radiation therapy of malignant tumors. Manual for physicians [Lineino-kvadratichnaya model' v raschetakh izoeffektivnykh doz, v otsenke protivoopukholevogo effekta i luchevykh reaktsii, i oslozhnenii pri luchevoi terapii zlokachestvennykh opukholei. Posobie dlya vrachei]. Moscow: RMAPO MZ i SR RF; 2004. (In Russ.)
Barendsen G. Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys. 1982;8(11):1981-1997. doi:10.1016/0360-3016(82)90459-x
Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB et al. Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys. 2010;76(3,Suppl.):S3-9.
Emami B, Lyman J, Brown A et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21(1):109-122. doi:10.1016/0360-3016(91)90171-y
Yarmonenko S. Now you need to tell the tale. Meditsinskaya radiologiya i radiatsionnaya bezopasnost'. 2005;(1):74-78. (In Russ.)
Klepper L. Determination of the optimal conditions for a system of radiation «tumor tissue + normal tissue (tumor bed)». Meditsinskaya fizika. 2015;(2):23-30. (In Russ.)
Klepper L. The justification of gipofraktsionirovaniya in radiation therapy of early breast cancer on the basis of mathematical modeling. Meditsinskaya fizika. 2015;(3):8-14. (In Russ.)
Stolyarova I, Vinokurov V. Problems of patients after treatment of cervical cancer (prevention and treatment of post-radiation complications).In: Tyulyandin S., Moiseenko V., eds. Practical oncology. Selected lectures [Prakticheskaya onkologiya. Izbrannye lektsii]. Sankt-Petersburg: «Tsentr TOMM»; 2004:700-708. (In Russ.)
Vinogradov V. Radiobiological bases of occurrence of radiation damage and their classification. In: Moiseenko V, Urmancheeva A, Khanson K, eds. Lectures on basic and clinical oncology [Lektsii po fundamental'noi i klinicheskoi onkologii]. Sankt-Petersburg: «Izdatel'stvo N-L»; 2014:598. (In Russ.)
Pasov V, Kurpesheva A, Terekhov O. Local radiation injuries in cancer patients (conservative treatment). In: Tsyb A, Mardynskii Yu, eds. Therapeutic radiology. Guidelines for doctors [Terapevticheskaya radiologiya. Rukovodstvo dlya vrachei]. Moscow: «MK»; 2010:519. (In Russ.)
Baumann M, Bentzen S. Clinical manifestations of normal-tissue damage. In: Steel G, ed. Basic clinical radiobiology. 3rd ed. London: H.Arnold; 2002:115.
www.rcr.ac.uk. 2006. Accessed March 6, 2016. Available at: https://www.rcr.ac.uk/sites/default/files/publication/Dose-Fractionation_Final.pdf
Statement from the 1987 como meeting of the international commission on radiological protection. Ann ICRP. 1987;17(4):i-v. doi:10.1016/0146-6453(87)90006-6
Radiation protection in medicine. Ann ICRP. 2007;37(6):1. doi:10.1016/j.icrp.2008.07.001
Radiotherapy in cancer management. A practical manual. London: WHO, Chapman&Hall Medical; 1997.