The clinical and morphological features of neuroendocrine carcinoma of the stomach and results of its surgical treatment

Vashakmadze L.A.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

ORCID: 0000-0002-3719-5388

Belous T.A.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF

Khomyakov V.M.

Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia

SPIN RSCI: 4081-7701
Scopus AuthorID: 56740937000
ORCID: 0000-0001-8301-4528

Cheremisov V.V.

Thoracoabdominal Surgical Department of P.A. Gertsen Moscow Research Oncology Institute, Health Ministry of the Russian Federation

The clinical and morphological features of neuroendocrine carcinoma of the stomach and results of its surgical treatment

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Vashakmadze L.A., Frank G.A., Belous T.A., Khomyakov V.M., Cheremisov V.V.

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Journal: P.A. Herzen Journal of Oncology. 2012;1(3): 4‑7

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To cite this article:

Vashakmadze LA, Frank GA, Belous TA, Khomyakov VM, Cheremisov VV. The clinical and morphological features of neuroendocrine carcinoma of the stomach and results of its surgical treatment. P.A. Herzen Journal of Oncology. 2012;1(3):4‑7. (In Russ.)

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The authors studied the results of treatment in 58 patients with neuroendocrine carcinoma (NEC) of the stomach in the period 1999 to 2011. Surgical treatment was performed in 55 (94.8%) of the 58 patients, medical treatment was done in 1 patient. An immunohistochemical study using a wide panel of markers was conducted to morphologically verify the diagnosis. The one- and three-year survival rates were 61.3 and 34.7%, respectively. The low survival rates are due to the predominance (70%) of patients with Stages III-IV disease and to the high aggressiveness of this tumor type, which suggests that the patients with locally advanced and metastatic NEC of the stomach even after radical surgery have a very poor prognosis. Gastric NEC is a high-grade tumor with an aggressive clinical course.

Keywords:

neuroendocrine cancer

neuroendocrine carcinoma

adenoneuroendocrine carcinoma

Authors:

Vashakmadze L.A.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

ORCID: 0000-0002-3719-5388

Belous T.A.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF

Khomyakov V.M.

Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia

SPIN RSCI: 4081-7701
Scopus AuthorID: 56740937000
ORCID: 0000-0001-8301-4528

Cheremisov V.V.

Thoracoabdominal Surgical Department of P.A. Gertsen Moscow Research Oncology Institute, Health Ministry of the Russian Federation

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