
Есть мнение
Журнал: Non nocere. Новый терапевтический журнал. 2026;(9):82-87.
Прочитано: 69 раз
Резюме
Влияние женских половых гормонов на экспрессию Toll-подобных рецепторов и репликацию ВИЧ-1.
Дата публикации: 13.10.2026
Литература / References
- Kawai T, Ikegawa M, Ori D, Akira S. Decoding Toll-like receptors: Recent insights and perspectives in innate immunity. Immunity. 2024;57(4):649-673. https://doi.org/10.1016/j.immuni.2024.03.004
- Carty M, Guy C, Bowie AG. Detection of Viral Infections by Innate Immunity. Biochem Pharmacol. 2021;183:114316. https://doi.org/10.1016/j.bcp.2020.114316
- Mekue LM, Nkenfou CN, Ngoufack MN, et al. Receptor 2 and 6 in the mother to child transmission of human immunodeficiency virus type-1. Biochem Mol Biol J. 2018;4(1):10. https://doi.org/10.21767/2471-8084.100059
- Lu W, Wang L, Xing J. Editorial: Antiviral innate immune sensing, regulation, and viral immune evasion. Front Immunol. 2024;14:1358542. https://doi.org/10.3389/fimmu.2023.1358542
- Heggelund L, Müller F, Lien E, et al. Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication. Clin Infect Dis. 2004;39(2):264-269. https://doi.org/10.1086/421780
- Browne EP. The Role of Toll-Like Receptors in Retroviral Infection. Microorganisms. 2020;8(11):1787. https://doi.org/10.3390/microorganisms8111787
- Nguyen H, Gazy N, Venketaraman V. A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response to Mycobacterium tuberculosis and Co-Infection with HIV. Int J Mol Sci. 2020;21(17):6148. https://doi.org/10.3390/ijms21176148
- Klein SL, Roberts CW. Sex and gender differences in infection and treatments for infectious diseases. Cham: Springer International Publishing; 2015. https://doi.org/10.1007/978-3-319-16438-0
- Nosik M, Ryzhov K, Rymanova I, et al. Dynamics of Plasmatic Levels of Pro- and Anti-Inflammatory Cytokines in HIV–Infected Individuals with M. tuberculosis Co-Infection. Microorganisms. 2021;9(11):2291. https://doi.org/10.3390/microorganisms9112291
- Shi Y, Ma J, Li S, et al. Sex difference in human diseases: mechanistic insights and clinical implications. Signal Transduct Target Ther. 2024;9(1):238. https://doi.org/10.1038/s41392-024-01929-7
- Addo MM, Altfeld M. Sex-based differences in HIV type 1 pathogenesis. J Infect Dis. 2014;209 Suppl 3(Suppl 3):S86-92. https://doi.org/10.1093/infdis/jiu175
- Rozman M, Zidovec-Lepej S, Jambrosic K, Babić M, Drmić Hofman I. Role of TLRs in HIV-1 Infection and Potential of TLR Agonists in HIV-1 Vaccine Development and Treatment Strategies. Pathogens. 2023; 12(1):92. https://doi.org/10.3390/pathogens12010092
- Donninelli G, Gessani S, Del Cornò M. Interplay between HIV-1 and Toll-like receptors in human myeloid cells: friend or foe in HIV-1 pathogenesis? J Leukoc Biol. 2016;99(1):97-105. https://doi.org/10.1189/jlb.4VMR0415-160R
- Hernández JC, Stevenson M, Latz E, Urcuqui-Inchima S. HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. AIDS Res Hum Retroviruses. 2012;28(10):1313-1328. https://doi.org/10.1089/aid.2011.0297
- Nosik M, Berezhnaya E, Bystritskaya E, et al. Female Sex Hormones Upregulate the Replication Activity of HIV-1 Sub-Subtype A6 and CRF02_AG but Not HIV-1 Subtype B. Pathogens. 2023;12(7):880. https://doi.org/10.3390/pathogens12070880
- Bolduc JF, Ouellet M, Hany L, Tremblay MJ. Toll-Like Receptor 2 Ligation Enhances HIV-1 Replication in Activated CCR6+ CD4+ T Cells by Increasing Virus Entry and Establishing a More Permissive Environment to Infection. J Virol. 2017;91(4):e01402-16. https://doi.org/10.1128/JVI.01402-16
- Del Cornò M, Cappon A, Donninelli G, Varano B, Marra F, Gessani S. HIV-1 gp120 signaling through TLR4 modulates innate immune activation in human macrophages and the biology of hepatic stellate cells. J Leukoc Biol. 2016;100(3):599-606. https://doi.org/10.1189/jlb.4A1215-534R
- Joshi A, Punke EB, Mehmetoglu-Gurbuz T, Peralta DP, Garg H. TLR9 polymorphism correlates with immune activation, CD4 decline and plasma IP10 levels in HIV patients. BMC Infect Dis. 2019;19(1):56. https://doi.org/10.1186/s12879-019-3697-9
- Vallejo A, Molina-Pinelo S, de Felipe B, et al. Brief Report: Toll-like Receptor 9-1635A/G Polymorphism Is Associated With HIV-1 Rebound After Four Weeks of Interruption of Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2020;85(2):252-256. https://doi.org/10.1097/QAI.0000000000002437
- Panel on Antiretroviral Guidelines for Adults and Adolescents. Women With HIV. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV. Department of Health and Human Services. Updated 12.09.2024. (date of access: August 10, 2026) https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/special-populations-women-hiv
- Panel on Antiretroviral Guidelines for Adults and Adolescents. Virologic Failure. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV. Department of Health and Human Services. Updated 12.09.2024. (date of access: August 10, 2026) https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/virologic-failure





