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Двойной удар

Двойной удар

Авторы:
Никита Владимирович Соловей

Журнал: Non nocere. Новый терапевтический журнал. 2026;(5):114-118.

Прочитано: 92 раза

Резюме

Рассеянный склероз и вирус Эпштейна – Барр: инфекция плюс аутоиммунитет.

Дата публикации: 29.05.2026

Литература / References
  1. Pender MP. Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infection. Autoimmun Rev. 2009;8(7):563-568. https://doi.org/10.1016/j.autrev.2009.01.017
  2. Alanazi A. Epstein-Barr Virus (EBV) and Multiple Sclerosis Disease: A Biomedical Diagnosis. Comput Intell Neurosci. 2022 Aug 18;2022:3762892. https://doi.org/10.1155/2022/3762892
  3. Bjornevik K, Münz C, Cohen JI, Ascherio A. Epstein-Barr virus as a leading cause of multiple sclerosis: mechanisms and implications. Nat Rev Neurol. 2023;19(3):160-171. https://doi.org/10.1038/s41582-023-00775-5
  4. Mohammadzamani M, Kazemzadeh K, Chand S, et al. Insights into the interplay between Epstein-Barr virus (EBV) and multiple sclerosis (MS): A state-of-the-art review and implications for vaccine development. Health Sci Rep. 2024;7(2):e1898. https://doi.org/10.1002/hsr2.1898
  5. Soldan SS, Lieberman PM. Epstein-Barr virus and multiple sclerosis. Nat Rev Microbiol. 2023;21(1):51-64. https://doi.org/10.1038/s41579-022-00770-5
  6. Afrasiabi A, Ahlenstiel C, Swaminathan S, Parnell GP. The interaction between Epstein-Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunities. Clin Transl Immunology. 2023;12(6):e1454. https://doi.org/10.1002/cti2.1454
  7. Houen G, Trier NH, Frederiksen JL. Epstein-Barr Virus and Multiple Sclerosis. Front Immunol. 2020;11:587078. https://doi.org/10.3389/fimmu.2020.587078
  8. Hedström AK. Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection. Front Immunol. 2023;14:1212676. https://doi.org/10.3389/fimmu.2023.1212676
  9. Vasileiou ES, Fitzgerald KC. Multiple Sclerosis Pathogenesis and Updates in Targeted Therapeutic Approaches. Curr Allergy Asthma Rep. 2023;23(9):481-496. https://doi.org/10.1007/s11882-023-01102-0
  10. Aloisi F, Cross AH. MINI-review of Epstein-Barr virus involvement in multiple sclerosis etiology and pathogenesis. J Neuroimmunol. 2022;371:577935. https://doi.org/10.1016/j.jneuroim.2022.577935
  11. Warner HB, Carp RI. Multiple sclerosis and Epstein-Barr virus. Lancet. 1981;2(8258):1290. https://doi.org/10.1016/s0140-6736(81)91527-0
  12. Thomas OG, Rickinson A, Palendira U. Epstein-Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism. Clin Transl Immunology. 2023;12(5): e1451. https://doi.org/10.1002/cti2.1451
  13. Wahbeh F, Sabatino JJ. Epstein-Barr Virus in Multiple Sclerosis: Past, Present, and Future. Neurol Neuroimmunol Neuroinflamm. 2025;12(6):e200460. https://doi.org/10.1212/NXI.0000000000200460
  14. Giovannoni G, James L, Adeniran AA, et al. The case for targeting latent and lytic Epstein-Barr virus infection in multiple sclerosis. Brain. 2025;148(9):3057-3071. https://doi.org/10.1093/brain/awaf170
  15. Park DJ. A unifying model for multiple sclerosis. Clin Exp Med. 2025;25(1):133. https://doi.org/10.1007/s10238-025-01666-3
  16. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995;80(5):695-705. https://doi.org/10.1016/0092-8674(95)90348-8
  17. Olmez O, Baba C, Abasiyanik Z, Ozakbas S. Epstein-Barr virus antibody in newly diagnosed multiple sclerosis patients and its association with relapse severity and lesion location. Mult Scler Relat Disord. 2022;68:104149. https://doi.org/10.1016/j.msard.2022.104149
  18. Vietzen H, Kühner LM, Berger SM, et al. Epstein-Barr Virus Antibodies to Differentiate Multiple Sclerosis From Other Neuroinflammatory Diseases. JAMA Neurol. 2026;83(5):461-470. https://doi.org/10.1001/jamaneurol.2026.0240
  19. Aloisi F, Giovannoni G, Salvetti M. Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy. Lancet Neurol. 2023;22(4):338-349. https://doi.org/10.1016/S1474-4422(22)00471-9
  20. Debuysschere C, Nekoua MP, Hober D. Markers of Epstein-Barr Virus Infection in Patients with Multiple Sclerosis. Microorganisms. 2023;11(5):1262. https://doi.org/10.3390/microorganisms11051262
  21. Dyer Z, Tscharke D, Sutton I, Massey J. From bedside to bench: how existing therapies inform the relationship between Epstein-Barr virus and multiple sclerosis. Clin Transl Immunology. 2023;12(2):e1437. https://doi.org/10.1002/cti2.1437
  22. Serafini B, Benincasa L, Rosicarelli B, Aloisi F. EBV infected cells in the multiple sclerosis brain express PD-L1: How the virus and its niche may escape immune surveillance. J Neuroimmunol. 2024;389:578314. https://doi.org/10.1016/j.jneuroim.2024.578114
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