ЖурналыПодпискаАрхивКнигиПроектыО насРекламаДоставка/ОплатаКонтакты
+7 (495) 482-43-29
  • Главная
  • / Журналы
  • / Вернуться в журнал
  • / Содержание номера
  • / Статья
Тяжелое дыхание

Тяжелое дыхание

Авторы:
Элла Георгиевна Арчегова,
Залина Руслановна Гусова,
Елизавета Олеговна Дзантиева

Журнал: Non nocere. Новый терапевтический журнал. 2026;(5):102-107.

Прочитано: 98 раз

Резюме

Бронхиальная астма у пациентов с ожирением: современные представления о проблеме.

Дата публикации: 29.05.2026

Литература / References
  1. Бронхиальная астма: рубрикатор клинических рекомендаций / Министерство здравоохранения Российской Федерации. – Электрон. дан. — 2024. — ID: 359_3. (дата обращения: 12.02.2026). https://cr.minzdrav.gov.ru/view-cr/359_3
  2. Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315-323. https://doi.org/10.1164/rccm.200906-0896OC
  3. Ожирение: рубрикатор клинических рекомендаций / Министерство здравоохранения Российской Федерации. – Электрон. дан. — 2024. — ID: 28_3. (дата обращения: 12.02.2026). https://cr.minzdrav.gov.ru/view-cr/28_3
  4. Баланова Ю.А., Шальнова С.А., Деев А.Д. и др. Ожирение в российской популяции — распространенность и ассоциации с факторами риска хронических неинфекционных заболеваний. Российский кардиологический журнал. 2018;(6):123-130. https://doi.org/10.15829/1560-4071-2018-6-123-130
  5. Claessen H, Brenner H, Drath C, Arndt V. Repeated measures of body mass index and risk of health related outcomes. Eur J Epidemiol. 2012;27(3):215-224. https://doi.org/10.1007/s10654-012-9669-7
  6. Parasuaraman G, Ayyasamy L, Aune D, et al. The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies. Sci Rep. 2023;13(1):7745. https://doi.org/10.1038/s41598-023-31373-6
  7. Jiang D, Wang L, Bai C, Chen O. Association between abdominal obesity and asthma: a meta-analysis. Allergy Asthma Clin Immunol. 2019;15:16. https://doi.org/10.1186/s13223-019-0333-6
  8. Chen Z, Salam MT, Alderete TL, et al. Effects of Childhood Asthma on the Development of Obesity among School-aged Children. Am J Respir Crit Care Med. 2017;195(9):1181-1188. https://doi.org/10.1164/rccm.201608-1691OC
  9. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol (1985). 2010;108(1):206-211. https://doi.org/10.1152/japplphysiol.00694.2009
  10. Mafort TT, Rufino R, Costa CH, Lopes AJ. Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function. Multidiscip Respir Med. 2016;11:28. https://doi.org/10.1186/s40248-016-0066-z
  11. Dixon AE, Peters U. The effect of obesity on lung function. Expert Rev Respir Med. 2018;12(9):755-767. https://doi.org/10.1080/17476348.2018.1506331
  12. Сергеева В.А. Патофизиология дыхания при ожирении. Пульмонология. 2021;31(6):808-815. https://doi.org/10.18.93/0869-01892021-31-6-808-815
  13. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest. 2006;130(3):827-833. https://doi.org/10.1378/chest.130.3.827
  14. Sood A, Ford ES, Camargo CA Jr. Association between leptin and asthma in adults. Thorax. 2006;61(4):300-305. https://doi.org/10.1136/thx.2004.031468
  15. Strissel KJ, Stancheva Z, Miyoshi H, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007;56(12):2910-2918. https://doi.org/10.2337/db07-0767
  16. Fjeldborg K, Christiansen T, Bennetzen M, J Møller H, Pedersen SB, Richelsen B. The macrophage-specific serum marker, soluble CD163, is increased in obesity and reduced after dietary-induced weight loss. Obesity (Silver Spring). 2013;21(12):2437-2443. https://doi.org/10.1002/oby.20376
  17. Al-Daghri NM, Al-Attas OS, Bindahman LS, et al. Soluble CD163 is associated with body mass index and blood pressure in hypertensive obese Saudi patients. Eur J Clin Invest. 2012;42(11):1221-1226. https://doi.org/10.1111/j.1365-2362.2012.02714.x
  18. Ouedraogo R, Gong Y, Berzins B, et al. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest. 2007;117(6):1718-1726. https://doi.org/110.1172/JCI29623
  19. Nie Z, Jacoby DB, Fryer AD. Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats. Am J Respir Cell Mol Biol. 2014;51(2):251-261. https://doi.org/10.1165/rcmb.2013-0452OC
  20. Al-Alwan A, Bates JH, Chapman DG, et al. The nonallergic asthma of obesity. A matter of distal lung compliance. Am J Respir Crit Care Med. 2014;189(12):1494-1502. https://doi.org/10.1164/rccm.201401-0178OC
  21. Chapman DG, Irvin CG, Kaminsky DA, Forgione PM, Bates JH, Dixon AE. Influence of distinct asthma phenotypes on lung function following weight loss in the obese. Respirology. 2014;19(8):1170-1177. https://doi.org/10.1111/resp.12368
  22. Bantulà M, Roca-Ferrer J, Arismendi E, Picado C. Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation. J Clin Med. 2021;10(2):169. https://doi.org/10.3390/jcm10020169
  23. Dixon AE, Holguin F, Sood A, et al. An official American Thoracic Society Workshop report: Obesity and asthma. Proc. Am. Thorac. Soc. 2010;7(5):325-335. https://doi.org/10.1513/pats.200903013ST
  24. Camargo CA Jr, Boulet LP, Sutherland ER, et al. Body mass index and response to asthma therapy: fluticasone propionate / salmeterol versus montelukast. J Asthma. 2010;47(1):76-82. https://doi.org/10.3109/02770900903338494
  25. Sutherland ER, Lehman EB, Teodorescu M, Wechsler ME; National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma. J Allergy Clin Immunol. 2009;123(6):1328-1334.e1. https://doi.org/10.1016/j.jaci.2009.04.005
  26. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006;27(3):495-503. https://doi.org/10.1183/09031936.06.00077205
  27. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med. 2007;101(11):2240-2247. https://doi.org/10.1016/j.rmed.2007.06.031
  28. Telenga ED, Tideman SW, Kerstjens HA, et al. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy. 2012;67(8):1060-1068. https://doi.org/10.1111/j.1398-9995.2012.02855.x
  29. Dias-Júnior SA, Reis M, de Carvalho-Pinto RM, Stelmach R, Halpern A, Cukier A. Effects of weight loss on asthma control in obese patients with severe asthma. Eur Respir J. 2014;43(5):1368-1377. https://doi.org/10.1183/09031936.00053413
  30. Macgregor AM, Greenberg RA. Effect of Surgically Induced Weight Loss on Asthma in the Morbidly Obese. Obes Surg. 1993;3(1):15-21. https://doi.org/10.1381/096089293765559700
  31. Maniscalco M, Zamparelli AS, Vitale DF, et al. Long-term effect of weight loss induced by bariatric surgery on asthma control and health related quality of life in asthmatic patients with severe obesity: A pilot study. Respir Med. 2017;130:69-74. http://doi.org/10.1016/j.rmed.2017.06.010
  32. Toh JJ, Pasupathy S, Poopalalingam RA, Koh MS. Can bariatric surgery be performed safely in patients with severe treatment-resistant asthma? Obes Surg. 2014;24(2):334-336. http://doi.org/10.1007/s11695-013-1138-1
  33. Bergmann NC, Davies MJ, Lingvay I, Knop FK. Semaglutide for the treatment of overweight and obesity: A review. Diabetes Obes Metab. 2023;25(1):18-35. http://doi.org/10.1111/dom.14863
  34. Мкртумян А.М., Егшатян Л.В. Эффективность семаглутида в свете доказательной медицины. Медицинский Совет. 2023;17(6):264-273. https://doi.org/10.21518/ms2022-010
  35. Zhu T, Wu XL, Zhang W, Xiao M. Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice. Int J Mol Sci. 2015;16(9):20195-20211. https://doi.org/10.3390/ijms160920195
  36. Шабутдинова О.Р., Даутов А.Р., Самков А.А. и др. Семаглутид — эффективность в снижении веса и побочные эффекты при применении по данным исследований SUSTAIN, PIONEER, STEP. Проблемы Эндокринологии. 2023;69(3):68-82. https://doi.org/10.14341/probl13197
  37. Zhang MQ, Lin C, Cai XL, et al. The Association between GLP-1 Receptor-Based Agonists and the Incidence of Asthma in Patients with Type 2 Diabetes and/or Obesity: A Meta-Analysis. Biomed Environ Sci. 2024;37(6):607-616. https://doi.org/10.3967/bes2024.067
  38. Wu AY, Cahill KN, Toki S, Peebles RS Jr. Evaluating the glucagon-like peptide-1 receptor in managing asthma. Curr Opin Allergy Clin Immunol. 2022;22(1):36-41. https://doi.org/10.1097/ACI.0000000000000797
  39. Foer D, Strasser ZH, Cui J, et al. Association of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes. Am J Respir Crit Care Med. 2023;208(10):1088-1100. https://doi.org/10.1164/rccm.202303-0491OC
  40. Billington CK, Ojo OO, Penn RB, Ito S. cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther. 2013;26(1):112-120. https://doi.org/10.1016/j.pupt.2012.05.007
  41. Brandfon S, Eylon A, Khanna D, Parmar MS. Advances in Anti-obesity Pharmacotherapy: Current Treatments, Emerging Therapies, and Challenges. Cureus. 2023;15(10):e46623. https://doi.org/10.7759/cureus.46623
  42. Taylor B, Mannino D, Brown C, Crocker D, Twum-Baah N, Holguin F. Body mass index and asthma severity in the National Asthma Survey. Thorax. 2008;63(1):14-20. https://doi.org/10.1136/thx.2007.082784
  43. Sutherland ER, Lehman EB, Teodorescu M, Wechsler ME; National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma. J Allergy Clin Immunol. 2009;123(6):1328-1334.e1. https://doi.org/10.1016/j.jaci.2009.04.005
  44. Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 1996;271(16):9550-9559. https://doi.org/10.1074/jbc.271.16.9550
  45. Sutherland ER, Goleva E, King TS, et al. Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012;7(5):e36631. https://doi.org/10.1371/journal.pone.0036631
  46. Heialy S, Gaudet M, Ramakrishnan RK, et al. Contribution of IL-17 in Steroid Hyporesponsiveness in Obese Asthmatics Through Dysregulation of Glucocorticoid Receptors α and β. Front Immunol. 2020;11:1724. https://doi.org/10.3389/fimmu.2020.01724
  47. Giouleka P, Papatheodorou G, Lyberopoulos P, et al. Body mass index is associated with leukotriene inflammation in asthmatics. Eur J Clin Invest. 2011;41(1):30-38. https://doi.org/10.1111/j.1365-2362.2010.02371.x
  48. Chakrabarti SK, Wen Y, Dobrian AD, et al. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab. 2011;300(1):E175-187. https://doi.org/10.1152/ajpendo.00203.2010
slide-cover
slide-cover
slide-cover
slide-cover
slide-cover
Издательство «Медиа Сфера»
РекламаДоставка/ОплатаО насКонтактыОбучение для редакцийПолитика конфиденциальностиПолитика обработки персональных данныхПубличная оферта на реализацию издательской продукции
ЖурналыПодпискаАрхивКнигиПроекты
  • RuStore

© 1998-2026

  • Телефоны издательства:

  • +7 (495) 482-41-18
  • +7 (495) 482-43-29
  • Прямой телефон отдела подписки
    (только по вопросам заказов и доставки журналов)

  • +7 (800) 250-18-12
  • пн-пт с 10:00 до 18:00

  • Telegram
  • VK
info@mediasphera.ru
  • Почтовый адрес:

  • Издательство «Медиа Сфера»,
    а/я 54, Москва, Россия, 127238

  • RuStore

© 1998-2026