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Kaibysheva V.O.

Pirogov Russian National Research Medical University;
Savelyeva City Clinical Hospital No. 31

Of particular concern

Authors:

Kaibysheva V.O.

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Journal: Non Nocere. New Therapeutic Journal. 2026;(1‑2): 60‑66

Read: 124 times

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To cite this article:

Kaibysheva VO. Of particular concern. Non Nocere. New Therapeutic Journal. 2026;(1‑2):60‑66. (In Russ.)

МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

Life-threatening gastrointestinal bleeding associated with the use of direct oral anticoagulants.

Authors:

Kaibysheva V.O.

Pirogov Russian National Research Medical University;
Savelyeva City Clinical Hospital No. 31

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References:

  1. Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 Sep 8;365(10):883-891.  https://doi.org/10.1056/NEJMoa1009638
  2. Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139-1151. https://doi.org/10.1056/NEJMoa0905561
  3. Abrignani MG, Gatta L, Gabrielli D, et al. Gastroprotection in patients on antiplatelet and/or anticoagulant therapy: a position paper of National Association of Hospital Cardiologists (ANMCO) and the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO). Eur J Intern Med. 2021 Mar;85:1-13.  https://doi.org/10.1016/j.ejim.2020.11.014
  4. Lanas-Gimeno A, Lanas A. Risk of gastrointestinal bleeding during anticoagulant treatment. Expert Opin Drug Saf. 2017 Jun;16(6):673-685.  https://doi.org/10.1080/14740338.2017.1325870
  5. AlLehibi AH, Alsubaie FF, Alzahrani RH, et al. Clinical Presentations and Risk Factors of Gastrointestinal Bleeding in the Emergency Department: A Multicenter Retrospective Study. Cureus. 2024 May 8;16(5):e59912. https://doi.org/10.7759/cureus.59912
  6. Abraham NS, Noseworthy PA, Yao X, Sangaralingham LR, Shah ND. Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study. Gastroenterology. 2017 Apr;152(5):1014-1022.e1.  https://doi.org/10.1053/j.gastro.2016.12.018
  7. Miller CS, Dorreen A, Martel M, Huynh T, Barkun AN. Risk of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2017 Nov;15(11):1674-1683.e3.  https://doi.org/10.1016/j.cgh.2017.04.031
  8. Hernandez I, Baik SH, Piñera A, Zhang Y. Risk of bleeding with dabigatran in atrial fibrillation. JAMA Intern Med. 2015 Jan;175(1):18-24.  https://doi.org/10.1001/jamainternmed.2014.5398
  9. Van Gelder IC, Rienstra M, Bunting KV, et al. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024 Sep 29;45(36):3314-3414. https://doi.org/10.1093/eurheartj/ehae176
  10. Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024 Sep 29;45(36):3415-3537. https://doi.org/10.1093/eurheartj/ehae177
  11. Ray WA, Chung CP, Murray KT, et al. Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding. JAMA. 2018 Dec 4;320(21):2221-2230. https://doi.org/10.1001/jama.2018.17242
  12. Kuvaev RO. Not sour! Non Nocere. New Therapeutic Journal. 2025;(4):80-86. (In Russ.)
  13. Moayyedi P, Eikelboom JW, Bosch J, et al. Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled Trial. Gastroenterology. 2019 Aug;157(2):403-412.e5.  https://doi.org/10.1053/j.gastro.2019.04.041
  14. Maev I.V., Zaborovsky A.V., Yurenev G.L., et al. Efficacy and safety of pantoprazole in the treatment of patients with gastroesophageal reflux disease in real-life clinical practice: a multicenter observational study. Medical Council. 2025;19(8): 24–31.  https://doi.org/10.21518/ms2025-230
  15. Maev I.V., Zaborovsky A.V., Tararina L.A., et al. Efficacy and safety of pantoprazole in the treatment of patients with acid-related diseases in Russia: a multicenter observational study. Effective Pharmacotherapy. 2023;19(43):20–27.  https://doi.org/10.33978/2307-3586-2023-19-43-20-27
  16. Package leaflet – information for the consumer: Nolpaza®, 20 mg and 40 mg, enteric-coated tablets, film-coated [Electronic resource] / State Register of Medicines (date accessed: 02/05/2026). https://grls.minzdrav.gov.ru/InstrImg/2025/06/10/1518013/95f4e0e1-5332-43b2-9e2a-3829d8c696cd.pdf
  17. Results of a comparative analysis of instructions for use of drugs with the INN pantoprazole, registered in the State Register of Medicines as of 05.02.2026 (author’s own data).
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