
Мы и МАБы
Журнал: Non nocere. Новый терапевтический журнал. 2025;(10):76-81.
Прочитано: 423 раза
Резюме
Генно-инженерные биологические препараты в лечении бронхиальной астмы: что нужно знать врачам общей практики и терапевтам первичного звена.
Дата публикации: 18.11.2025
Литература / References
- Skloot GS. Asthma phenotypes and endotypes: a personalized approach to treatment. Curr Opin Pulm Med. 2016 Jan;22(1):3-9. https://doi.org/10.1097/MCP.0000000000000225
- Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2024. Last updated: May 2024 [Electronic resource]. Access date: May 14, 2024. https://ginasthma.org/wp-content/uploads/2024/05/GINA-2024-Main-Report-WMS-1.pdf
- Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014 Feb;43(2):343-373. https://doi.org/10.1183/09031936.00202013
- Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010 Nov;126(5):926-938. https://doi.org/10.1016/j.jaci.2010.07.019
- Chung KF. Managing severe asthma in adults: lessons from the ERS/ATS guidelines. Curr Opin Pulm Med. 2015 Jan;21(1):8-15. https://doi.org/10.1097/MCP.0000000000000116
- Mansur AH, Prasad N. Management of difficult-to-treat asthma in adolescence and young adults. Breathe (Sheff). 2023 Mar;19(1):220025. https://doi.org/10.1183/20734735.0025-2022
- Lloyd CM, Robinson DS. Allergen-induced airway remodelling. Eur Respir J. 2007 May;29(5):1020-1032. https://doi.org/10.1183/09031936.00150305
- Hylkema MN, Sterk PJ, de Boer WI, Postma DS. Tobacco use in relation to COPD and asthma. Eur Respir J. 2007 Mar;29(3):438-445. https://doi.org/10.1183/09031936.00124506
- Venancio-Hernández M, Mendieta-Flores E, Mendiola-Marín J, Alaniz-Flores AK, Reyes-Arellano M. Abordaje diagnóstico del asma difícil de tratar y asma grave [The diagnostic approach to difficult-to-treat asthma and severe asthma]. Rev Alerg Mex. 2022;69 Suppl 1:s94–s111. Spanish. https://doi.org/10.29262/ram.v69iSupl1.1046
- The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J. 2003 Sep;22(3):470-477. https://doi.org/10.1183/09031936.03.00261903
- Tan R, Liew MF, Lim HF, Leung BP, Wong WSF. Promises and challenges of biologics for severe asthma. Biochem Pharmacol. 2020 Sep;179:114012. https://doi.org/10.1016/j.bcp.2020.114012
- Dahlén SE. Asthma phenotyping: noninvasive biomarkers suitable for bedside science are the next step to implement precision medicine. J Intern Med. 2016 Feb;279(2):205-207. https://doi.org/10.1111/joim.12466
- Hekking PW, Wener RR, Amelink M, Zwinderman AH, Bouvy ML, Bel EH. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015 Apr;135(4):896-902. https://doi.org/10.1016/j.jaci.2014.08.042
- Agache I, Beltran J, Akdis C, et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines – recommendations on the use of biologicals in severe asthma. Allergy. 2020 May;75(5):1023-1042. https://doi.org/10.1111/all.14221
- Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma. N Engl J Med. 2021 May 13;384(19):1800-1809. https://doi.org/10.1056/NEJMoa2034975
- Buhl R, Korn S, Menzies-Gow A, et al. Prospective, Single-Arm, Longitudinal Study of Biomarkers in Real-World Patients with Severe Asthma. J Allergy Clin Immunol Pract. 2020 Sep;8(8):2630-2639.e6. https://doi.org/10.1016/j.jaip.2020.03.038
- Tran TN, Zeiger RS, Peters SP, et al. Overlap of atopic, eosinophilic, and TH2-high asthma phenotypes in a general population with current asthma. Ann Allergy Asthma Immunol. 2016 Jan;116(1):37-42. https://doi.org/10.1016/j.anai.2015.10.027
- Djukanović R, Wilson SJ, Kraft M, et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med. 2004 Sep 15;170(6):583-593. https://doi.org/10.1164/rccm.200312-1651OC
- Pan S, Conaway S Jr, Deshpande DA. Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases. Arch Biochem Biophys. 2019 Mar 15;663:109-119. https://doi.org/10.1016/j.abb.2019.01.002
- Roth M, Zhao F, Zhong J, Lardinois D, Tamm M. Serum IgE Induced Airway Smooth Muscle Cell Remodeling Is Independent of Allergens and Is Prevented by Omalizumab. PLoS One. 2015 Sep 2;10(9):e0136549. https://doi.org/10.1371/journal.pone.0136549
- Vennera MDC, Sabadell C, Picado C; Spanish Omalizumab Registry. Duration of the efficacy of omalizumab after treatment discontinuation in ‘real life’ severe asthma. Thorax. 2018 Aug;73(8):782-784. https://doi.org/10.1136/thoraxjnl-2017-210017
- Baena-Cagnani CE, Teijeiro A, Canonica GW. Four-year follow-up in children with moderate/severe uncontrolled asthma after withdrawal of a 1-year omalizumab treatment. Curr Opin Allergy Clin Immunol. 2015 Jun;15(3):267-271. https://doi.org/10.1097/ACI.0000000000000161
- Kim DH, Park KY, Kim BJ, Kim MN, Mun SK. Anti-immunoglobulin E in the treatment of refractory atopic dermatitis. Clin Exp Dermatol. 2013 Jul;38(5):496-500. https://doi.org/10.1111/j.1365-2230.2012.04438.x
- Naclerio RM, Baroody FM, Pinto JM. Should clinicians use omalizumab for the treatment of nasal polyps? J Allergy Clin Immunol. 2013 Jul;132(1):247. https://doi.org/10.1016/j.jaci.2013.04.001
- Gevaert P, Calus L, Van Zele T, et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol. 2013 Jan;131(1):110-116.e1. https://doi.org/10.1016/j.jaci.2012.07.047
- Agache I, Rocha C, Beltran J, et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines – recommendations on the use of biologicals in severe asthma. Allergy. 2020 May;75(5):1043-1057. https://doi.org/10.1111/all.14235
- Deeks ED, Brusselle G. Reslizumab in Eosinophilic Asthma: A Review. Drugs. 2017 May;77(7):777-784. https://doi.org/10.1007/s40265-017-0740-2
- Máspero J. Reslizumab in the treatment of inadequately controlled asthma in adults and adolescents with elevated blood eosinophils: clinical trial evidence and future prospects. Ther Adv Respir Dis. 2017 Aug;11(8):311-325. https://doi.org/10.1177/1753465817717134
- Albers FC, Price RG, Smith SG, Yancey SW. Mepolizumab efficacy in patients with severe eosinophilic asthma receiving different controller therapies. J Allergy Clin Immunol. 2017 Nov;140(5):1464-1466.e4. https://doi.org/10.1016/j.jaci.2017.06.010
- Caminati M, Cegolon L, Vianello A, et al. Mepolizumab for severe eosinophilic asthma: a real-world snapshot on clinical markers and timing of response. Expert Rev Respir Med. 2019 Dec;13(12):1205-1212. https://doi.org/10.1080/17476348.2019.1676734
- Bakakos A, Rovina N, Bakakos P. Treatment Challenges in Severe Eosinophilic Asthma: Differential Response to Anti-IL-5 and Anti-IL-5R Therapy. Int J Mol Sci. 2021 Apr 12;22(8):3969. https://doi.org/10.3390/ijms22083969
- Matera MG, Rogliani P, Calzetta L, Canonica GW, Cazzola M. Benralizumab for the treatment of asthma. Drugs Today (Barc). 2017 Dec;53(12):633-645. https://doi.org/10.1358/dot.2017.53.12.2736670
- Pelaia C, Busceti MT, Crimi C, et al. Real-Life effects of benralizumab on exacerbation number and lung hyperinflation in atopic patients with severe eosinophilic asthma. Biomed Pharmacother. 2020 Sep;129:110444. https://doi.org/10.1016/j.biopha.2020.110444
- Gavett SH, O’Hearn DJ, Karp CL, et al. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am J Physiol. 1997 Feb;272(2 Pt 1):L253-261. https://doi.org/10.1152/ajplung.1997.272.2.L253
- Rabe KF, Nair P, Brusselle G, et al. Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma. N Engl J Med. 2018 Jun 28;378(26):2475-2485. https://doi.org/10.1056/NEJMoa1804093
- Gour N, Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015 Sep;75(1):68-78. https://doi.org/10.1016/j.cyto.2015.05.014
- Bleck B, Tse DB, Curotto de Lafaille MA, Zhang F, Reibman J. Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin. J Clin Immunol. 2008 Mar;28(2):147-156. https://doi.org/10.1007/s10875-007-9149-0
- Corren J, Parnes JR, Wang L, et al. Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017 Sep 7;377(10):936-946. https://doi.org/10.1056/NEJMoa1704064
- Emson C, Corren J, Sałapa K, Hellqvist Å, Parnes JR, Colice G. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with and without Nasal Polyposis: A Post Hoc Analysis of the Phase 2b PATHWAY Study. J Asthma Allergy. 2021 Feb 3;14:91-99. https://doi.org/10.2147/JAA.S288260
- Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. Am J Respir Crit Care Med. 2023 Jul 1;208(1):13-24. https://doi.org/10.1164/rccm.202210-2005OC



