Endogenic antimicrobial peptides and cytokines in calculous cholecystitis

Gadzhiev J.N.; Gadzhiev N.J.; Gasymova Sh.Kh.

doi:https://doi.org/10.17116/hirurgia201810151

Gadzhiev J.N.

Azerbaijan Medical University, Baku, Azerbaijan

Gadzhiev N.J.

Azerbaijan Medical University, Baku, Azerbaijan

Gasymova Sh.Kh.

Azerbaijan Medical University, Baku, Azerbaijan

Endogenic antimicrobial peptides and cytokines in calculous cholecystitis

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Gadzhiev J.N., Gadzhiev N.J., Gasymova Sh.Kh.

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Journal: Pirogov Russian Journal of Surgery. 2018;(10): 51‑54

DOI: 10.17116/hirurgia201810151

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To cite this article:

Gadzhiev JN, Gadzhiev NJ, Gasymova ShKh. Endogenic antimicrobial peptides and cytokines in calculous cholecystitis. Pirogov Russian Journal of Surgery. 2018;(10):51‑54. (In Russ.)
https://doi.org/10.17116/hirurgia201810151

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

Aim. To analyze concentration of some antimicrobial peptides and cytotoxins in acute calculous cholecystitis regarding gallbladder inflammation grade. Material and methods. There were 69 patients with catarrhal (29), phlegmonous (24) inflammation and gangrenous phlegmon (19). Some antimicrobial peptides (HNP-α, BPI, endotoxin, neutrophil elastase, lactoferritin, hepcidin) and cytokines (TNF-α, IL-6, 8, 10) in blood serum as well as hepcidin, TNF-α and IL-6 in hepatic biopsy samples were assessed. Results. Significantly increased concentration of all antimicrobial peptides and cytokines was observed in all patients at admission compared with healthy persons. Changes depended on severity of gallbladder inflammation. There was a positive correlation of antimicrobial peptides and TNF-α, IL-6, IL-8. Conclusion. The use of antimicrobial peptides as the most informative biomarker for early diagnosis of destructive acute cholecystitis reduces postoperative morbidity.

Keywords:

hepcidin

α-defensin

acute calculous cholecystitis

Authors:

Gadzhiev J.N.

Azerbaijan Medical University, Baku, Azerbaijan

Gadzhiev N.J.

Azerbaijan Medical University, Baku, Azerbaijan

Gasymova Sh.Kh.

Azerbaijan Medical University, Baku, Azerbaijan

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References:

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