Endogenic antimicrobial peptides and cytokines in calculous cholecystitis

Gadzhiev J.N.

Azerbaijan Medical University, Baku, Azerbaijan

Gadzhiev N.J.

Azerbaijan Medical University, Baku, Azerbaijan

Gasymova Sh.Kh.

Azerbaijan Medical University, Baku, Azerbaijan

Endogenic antimicrobial peptides and cytokines in calculous cholecystitis

Authors:

Gadzhiev J.N., Gadzhiev N.J., Gasymova Sh.Kh.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2018;(10): 51‑54

DOI: 10.17116/hirurgia201810151

Downloaded: 17

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Gadzhiev JN, Gadzhiev NJ, Gasymova ShKh. Endogenic antimicrobial peptides and cytokines in calculous cholecystitis. Pirogov Russian Journal of Surgery. 2018;(10):51‑54. (In Russ.)
https://doi.org/10.17116/hirurgia201810151

Подписка 2025 (Pirogov Russian Journal of Surgery)

Close metadata

Recommended articles:

Potentially preventable causes of mortality in acute calculous cholecystitis: a population-based study. Pirogov Russian Journal of Surgery. 2024;(7):5-15

Experience of indocyanine green use in acute calculous cholecystitis. Pirogov Russian Journal of Surgery. 2024;(8):52-56

Comparative analysis of laparoscopic cholecystectomy outcomes in acute calculous cholecystitis: importance of indocyanine green, optimal dosing regimen. Pirogov Russian Journal of Surgery. 2024;(11):72-76

Aim. To analyze concentration of some antimicrobial peptides and cytotoxins in acute calculous cholecystitis regarding gallbladder inflammation grade. Material and methods. There were 69 patients with catarrhal (29), phlegmonous (24) inflammation and gangrenous phlegmon (19). Some antimicrobial peptides (HNP-α, BPI, endotoxin, neutrophil elastase, lactoferritin, hepcidin) and cytokines (TNF-α, IL-6, 8, 10) in blood serum as well as hepcidin, TNF-α and IL-6 in hepatic biopsy samples were assessed. Results. Significantly increased concentration of all antimicrobial peptides and cytokines was observed in all patients at admission compared with healthy persons. Changes depended on severity of gallbladder inflammation. There was a positive correlation of antimicrobial peptides and TNF-α, IL-6, IL-8. Conclusion. The use of antimicrobial peptides as the most informative biomarker for early diagnosis of destructive acute cholecystitis reduces postoperative morbidity.

Keywords:

hepcidin

α-defensin

acute calculous cholecystitis

Authors:

Gadzhiev J.N.

Azerbaijan Medical University, Baku, Azerbaijan

Gadzhiev N.J.

Azerbaijan Medical University, Baku, Azerbaijan

Gasymova Sh.Kh.

Azerbaijan Medical University, Baku, Azerbaijan

List of references:

Gadzhiev DzhN, Gadzhiev NDzh, Mamedova ZB. Khirurgiya. 2017;10:61-67. (In Russ.)
Lutsevich OE, Urbanovich AS, Amirkhanov AA. Postoperative complications in acute cholecystitis and its complicated forms in elderly and senile patients. Moskovskii Khirurgicheskii Zhurnal. 2012;6:17-23. (In Russ.)
Oreshkin AYu, Bykov AV, Vorob’ev AI. The latent form of destructive cholecystitis (clinical and immuno-biological aspects). Byulleten’ Volgogradskogo nauchnogo tsentra RAMN. 2008;4:30-33. (In Russ.)
Bystrov SV, Gorkh PI, Chir’ev AI., et al. Morphological features of the course of chronic cholecystitis in cholelithiasis. Voprosy rekonstruktivnoi i plasticheskoi khirurgii. 2015;4:43-45. (In Russ.)
Makarov Aİ, Vorobeva NA, Dobrodeeva LK, Makarova Vİ, Laboratory criteria of systemic inflammatory syndrome by surgical abdominal infections. Khirurgiya. 2009;5:40-45. (In Russ.)
Gadzhiev DzhN, Allakhverdiev VA, Gadzhiev NDzh. Features of disorders in the system of cytokines and lipid peroxidation in acute ulcerative gastroduodenal hemorrahages. Kazanskii Meditsinskii zhurnal. 2017;5:686-691. (In Russ.)
Meditsinskaya mikrobiologiya, virusologiya i immunologiya. Pod. red. AS Bykova, VV Zvereva. M.: Izdatel’stvo Meditsinskoe inform. agentstvo; 2018. (In Russ.).
Azizova GI, Gasanova ShI, Niyazova NK, et al. Secretion level of some endogenous antimicrobial peptides and certain cytokines in type 2 diabetes mellitus. Kazanskii Meditsinskii zhurnal. 2014;5:646-649. (In Russ.)
Khaitov RM, Yarilin AA, Pinegin BV. Immunologiya. M.: GEOTAR-Media; 2011. (In Russ.)
Barnes NC, Anderson ME, Moots RJ. The Many faces of İnterleukin-6: The Role of İL-6 in inflammation, Vasculopathy and fibrosis in Systemic Sclerosis. İnternational Journal of Rheumatology. 2011; Article ID 721608, 6 pages.
Rosello-Lieti E, Rivera M, Bertomeu V, et al. İnterleukin-4 and cardiac fibrosis in Patients With Heart Failure. Rev Esp Cardiol. 2007;60(7):1-24.
Mamchur VI, Levykh AE. Defensins — peptides with antiinfective and antitumor properties. Bolezni i Antibiotiki. 2012;2:27-39. (In Russ.)
Yang D, Chen Q, Chertov O, Oppenheim JJ. Human neutrophil defensis selectively chemoattract naïve T and immature dendritic cels. J Leukoc Biol. 2000;68:9-14.
Lehrer RI, Lu W. α-Defensins in human innate immunity. Immunol Rev. 2012;1:84-112.
Danilov IP, Smirnova LA, Kozich ZhM, Kravchuk ZI. Clinical significance of markers of iron metabolism: ferritin, transferrin, hepcidin. Zdravookhranenie. 2011;9:30-35. (In Russ.)

Close metadata