Morphological precursors of high-grade serous ovarian cancer

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At the beginning of this century, there was a paradigm shift in understanding the histogenesis of high-grade serous carcinomas. The theory of the origin of these tumors from the ovarian surface epithelium was replaced by the concept of their origin from the secretory epithelium of the fallopian tubes. In recent years, researchers have put forward the hypothesis of the “escape” of the precursor of high-grade serous carcinomas. It allows looking at the carcinogenesis of these neoplasms as a natural history of tumor transformation of the serous epithelium without reference to a specific localization.

Keywords:

high-grade serous carcinoma

STIC

p53 signature

precursor escape

serous carcinogenesis

Authors:

Novikov F.V.

Kursk State Medical University of the Ministry of Health of Russia

Efremov G.D.

N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology — branch of the National Medical Research Radiological Center

Received:

20.09.2022

Accepted:

26.10.2022

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