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Samsonova M.V.

Research Institute of Pulmonology;
A.S. Loginov Moscow Clinical Research Center

Chernyayev A.L.

Research Institute of Pulmonology;
Acad. A.P. Avtsyn Research Institute of Human Morphology;
N.I. Pirogov Russian National Research Medical University

Dvorakovskaya I.V.

Research Institute of Pulmonology of the Acad. I.P. Pavlov First Saint Petersburg State Medical University;
Saint Petersburg Research Institute of Phthisiopulmonology

Kusraeva E.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Comparative pathomorphological characteristics of idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis

Authors:

Samsonova M.V., Chernyayev A.L., Dvorakovskaya I.V., Kusraeva E.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(1): 59‑66

DOI: 10.17116/patol20228401159

Read: 3802 times

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Table of contents

COMPARATIVE PATHOMORPHOLOGICAL CHARACTERISTICS OF IDIOPATHIC PULMONARY FIBROSIS AND FIBROTIC HYPERSENSITIVITY PNEUMONITIS
COMPARATIVE PATHOMORPHOLOGICAL CHARACTERISTICS OF IDIOPATHIC PULMONARY FIBROSIS AND FIBROTIC HYPERSENSITIVITY PNEUMONITIS

To cite this article:

Samsonova MV, Chernyayev AL, Dvorakovskaya IV, Kusraeva EV. Comparative pathomorphological characteristics of idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis. Russian Journal of Archive of Pathology. 2022;84(1):59‑66. (In Russ.)
https://doi.org/10.17116/patol20228401159

 
Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The paper presents an X-ray morphological differential diagnosis of idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (FHP). It describes the etiology, pathogenesis, radiological signs, and pathoanatomy of IPF and FHP. For differential diagnosis, radiological and morphological signs were studied in 105 patients with IPF and in 111 patients with FHP. The mean ages of patients with IPF or FHP were 65.0±8.9 and 48.9±12.3 years, respectively. The history of IPF to the moment of its diagnosis ranged from 1 to 18 months, while that of FHP was 35 to 79 days. The authors describe the additional morphological signs of FHP: delicate collagen fibrosis; smooth muscle metaplasia in the interalveolar septa and fibrotic areas; fibroblastic foci mainly in the walls of bronchioles; plasma cell infiltration of interalveolar septa with a touch of neutrophils and eosinophils. A table has been compiled for differential diagnosis according to the morphological signs of IPF and FHP.

Keywords:

idiopathic pulmonary fibrosis
fibrotic hypersensitivity pneumonitis
morphological signs of fibrosis

Authors:

Samsonova M.V.

Research Institute of Pulmonology;
A.S. Loginov Moscow Clinical Research Center

Chernyayev A.L.

Research Institute of Pulmonology;
Acad. A.P. Avtsyn Research Institute of Human Morphology;
N.I. Pirogov Russian National Research Medical University

Dvorakovskaya I.V.

Research Institute of Pulmonology of the Acad. I.P. Pavlov First Saint Petersburg State Medical University;
Saint Petersburg Research Institute of Phthisiopulmonology

Kusraeva E.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Received:

08.10.2021

Accepted:

10.11.2021

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References:

  1. Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F, Flaherty KR, Wells A, Martinez FJ, Azuma A, Bice TJ, Bouros D, Brown KK, Collard HR, Duggal A, Galvin L, Inoue Y, Jenkins RG, Johkoh T, Kazerooni EA, Kitaichi M, Knight SL, Mansour G, Nicholson AG, Pipavath SNJ, Buendía-Roldán I, Selman M, Travis WD, Walsh S, Wilson KC; American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society. Diagnosis of idiopathic pulmonary fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2018;198(5):44-68.  https://doi.org/10.1164/rccm.201807-1255ST
  2. Raghu G, Remy-Jardin M, Ryerson CJ, Myers JL, Kreuter M, Vasakova M, Bargagli E, Chung JH, Collins BF, Bendstrup E, Chami HA, Chua AT, Corte TJ, Dalphin JC, Danoff SK, Diaz-Mendoza J, Duggal A, et al. Diagnosis of hypersensitivity pneumonitis in adults. An Official ATS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2020;202(3):36-69.  https://doi.org/10.1164/rccm.202005-2032ST
  3. Fernández Pérez ER, Travis WD, Lynch DA, Brown KK, Johannson KA, Selman M, Ryu JH, Wells AU, Tony Huang YC, Pereira CAC, Scholand MB, Villar A, Inase N, Evans RB, Mette SA, Frazer-Green L. Executive summary: diagnosis and evaluation of hypersensitivity pneumonitis: CHEST guideline and expert panel report. Chest. 2021;160(2):595-615.  https://doi.org/10.1016/j.chest.2021.03.067.
  4. Morisset J, Johannson KA, Jones KD, Wolters PJ, Collard HR, Walsh SLF, Ley B; HP Delphi Collaborators. Identification of diagnostic criteria for chronic hypersensitivity pneumonitis: an international modified delphi survey. Am J Respir Crit Care Med. 2018;197(8):1036-1044. https://doi.org/10.1164/rccm.201710-1986OC
  5. Troy LK, Grainge C, Corte TJ, Williamson JP, Vallely MP, Cooper WA, Mahar A, Myers JL, Lai S, Mulyadi E, Torzillo PJ, Phillips MJ, Jo HE, Webster SE, Lin QT, Rhodes JE, Salamonsen M, Wrobel JP, Harris B, Don G, Wu PJC, Ng BJ, Oldmeadow C, Raghu G, Lau EMT; Cryobiopsy versus Open Lung biopsy in the Diagnosis of Interstitial lung disease alliance (COLDICE) Investigators. Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study. Lancet Respir Med. 2020;8(2):171-181.  https://doi.org/10.1016/S2213-2600(19)30342-X
  6. Kogan EA, Tyong FV, Demura SA. The mechanism of lung tissue remodeling in the progression of idiopathic pulmonary fibrosis. Arkh Patol. 2010;72(4):30-36. (In Russ.).
  7. Popper H. Pathology of lung disease. Morphology-pathogenesis-etiology. Berlin, Heidelberg: Spuiner-Verlag; 2017;177-178. 
  8. Mikumo H, Yanagihara T, Hamada N, Hashisako M, Ijichi K, Suzuki K, Harada E, Shikada Y, Oda Y, Nakanishi Y. An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation. Respir Med Case Rep. 2018;24:92-94.  https://doi.org/10.1016/j.rmcr.2018.04.016
  9. Roden AC, Camus P. Iatrogenic pulmonary lesions. Semin Diagn Pathol. 2018;35(4):260-271.  https://doi.org/10.1053/j.semdp.2018.03.002
  10. Chong BJ, Kanne JP, Chung JH. Headcheese sign. J Thorac Imaging. 2014;29(1):W13.  https://doi.org/10.1097/RTI.0000000000000067
  11. Wang LJ, Cai HR, Xiao YL, Wang Y, Cao MS. Clinical characteristics and outcomes of hypersensitivity pneumonitis: a population-based study in China. Chin Med J (Engl). 2019;132(11):1283-92. Erratum in: Chin Med J (Engl). 2021;134(3):378.  https://doi.org/10.1097/CM9.0000000000000256
  12. Dias OM, Baldi BG, Pennati F, Aliverti A, Chate RC, Sawamura MVY, Carvalho CRR, Albuquerque ALP. Computed tomography in hypersensitivity pneumonitis: main findings, differential diagnosis and pitfalls. Expert Rev Respir Med. 2018;12(1):5-13.  https://doi.org/10.1080/17476348.2018.1395282
  13. Barnett J, Molyneaux PL, Rawal B, Abdullah R, Hare SS, Vancheeswaran R, Desai SR, Maher TM, Wells AU, Devaraj A. Variable utility of mosaic attenuation to distinguish fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis. Eur Respir J. 2019;54(1):1900531. https://doi.org/10.1183/13993003.00531-2019
  14. Myers JL. Hypersensitivity pneumonia: the role of lung biopsy in diagnosis and management. Mod Pathol. 2012;25(suppl 1):58-67.  https://doi.org/10.1038/modpathol.2011.152
  15. Mooney JJ, Koth LL. Surgical lung biopsy over bronchoalveolar lavage in chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2014;189(3):371-372.  https://doi.org/10.1164/rccm.201309-1736LE
  16. Ganganah O, Guo SL, Chiniah M, Li YS. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: A systematic review and meta-analysis. Respirology. 2016;21(5):834-841.  https://doi.org/10.1111/resp.12770
  17. Il’kovich MM, Novikova LN, Orlova GP. Ekzogennyy allergicheskiy al’veolit. In: Il’kovich M.M., ed. Disseminirovannyye zabolevaniya legkikh. M.: GEOTAR-Media; 2011;83-111. (In Russ.).
  18. Putov NV, Il’kovich MM. Fibroziruyushchiye al’veolity. L.: Meditsina; 1986. (In Russ.).
  19. Churg A, Muller NL, Flint J, Wright JL. Chronic hypersensitivity pneumonitis. Am J Surg Pathol. 2006;30(2):201-208.  https://doi.org/10.1097/01.pas.0000184806.38037.3c
  20. Takemura T, Akashi T, Ohtani Y, Inase N, Yoshizawa Y. Pathology of hypersensitivity pneumonitis. Curr Opin Pulm Med. 2008;14(5):440-454.  https://doi.org/10.1097/MCP.0b013e3283043dfa
  21. Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL. Pathologic findings and prognosis in a large prospective cohort of chronic hypersensitivity pneumonitis. Chest. 2017;152(3):502-509.  https://doi.org/10.1016/j.chest.2017.02.011
  22. https://doi.org/10.17116/patol201476628-36  https://doi.org/10.17116/patol201476628-36
  23. Castonguay MC, Ryu JH, Yi ES, Tazelaar HD. Granulomas and giant cells in hypersensitivity pneumonitis. Hum Pathol. 2015;46(4): 607-613.  https://doi.org/10.1016/j.humpath.2014.12.017
  24. Katzenstein AA, Askin FB. Surgical pathology of non-neoplastic lung disease. Major Probl Pathol. 1982;13:1-430. 
  25. Franks TJ, Galvin JR. Hypersensitivity pneumonitis: essential radiologic and pathologic findings. Surg Pathol Clin. 2010;3(1):187-198.  https://doi.org/10.1016/j.path.2010.03.005
  26. Glazer CS. Chronic hypersensitivity pneumonitis: important considerations in the work-up of this fibrotic lung disease. Curr Opin Pulm Med. 2015;21(2):171-177.  https://doi.org/10.1097/MCP.0000000000000137
  27. García de Alba C, Buendia-Roldán I, Salgado A, Becerril C, Ramírez R, González Y, Checa M, Navarro C, Ruiz V, Pardo A, Selman M. Fibrocytes contribute to inflammation and fibrosis in chronic hypersensitivity pneumonitis through paracrine effects. Am J Respir Crit Care Med. 2015;191(4):427-436.  https://doi.org/10.1164/rccm.201407-1334OC
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