Phosphorus (P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive pH. A study involving 23 volunteers. Part I

Pronin I.N.; Zakharova N.E.; Podoprigora A.E.; Batalov A.I.; Tyurina A.N.; Mertsalova M.P.; Fadeeva L.M.; Golanov A.V.; Postnov A.A.; Rodionov P.V.; Potapov A.A.

doi:https://doi.org/10.17116/neiro2019830215

Pronin I.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Zakharova N.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Podoprigora A.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Batalov A.I.

Burdenko Neurosurgical Institute, Moscow, Russia

Tyurina A.N.

Burdenko Neurosurgical Institute, Moscow, Russia

Mertsalova M.P.

Burdenko Neurosurgical Institute, Moscow, Russia

Fadeeva L.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Golanov A.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

ORCID: 0000-0002-0976-4547

Postnov A.A.

Vserossiĭskiĭ tsentr ékstrennoĭ i radiatsionnoĭ meditsiny im. A.M. Nikiforova MChS Rossii, Sankt-Peterburg

Rodionov P.V.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Phosphorus (P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive pH. A study involving 23 volunteers. Part I

Authors:

Pronin I.N., Zakharova N.E., Podoprigora A.E., Batalov A.I., Tyurina A.N., Mertsalova M.P., Fadeeva L.M., Golanov A.V., Postnov A.A., Rodionov P.V., Potapov A.A.

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Journal: Burdenko's Journal of Neurosurgery. 2019;83(2): 5‑10

DOI: 10.17116/neiro2019830215

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To cite this article:

Pronin IN, Zakharova NE, Podoprigora AE, et al. . Phosphorus (P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive pH. A study involving 23 volunteers. Part I. Burdenko's Journal of Neurosurgery. 2019;83(2):5‑10. (In Russ., In Engl.)
https://doi.org/10.17116/neiro2019830215

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

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Abstract:

Evaluation of brain metabolism is an important part in examination of brain lesions. Phosphorus magnetic resonance spectroscopy opens up great opportunities for studying the energy metabolism and allows noninvasive examination of metabolic processes occurring both in healthy and in pathologic brain tissue by obtaining a spectrum of phosphorus-containing metabolites involved in the turnover of cell membrane phospholipids. The technique presented in this paper was used to conduct 31P MR spectroscopy and to estimate the ratio between the peaks of the main metabolites and intracellular pH of the healthy brain tissue of 23 volunteers in the age group under 30 years old in clinical settings. Based on the recorded stable phosphorus spectra of metabolites of the healthy brain tissue, the value of intracellular pH (6.963±0.044) and the ratio of the main PME/PDE peaks (1.17±0.20) were calculated. The database was created to subsequently analyze the metabolic changes in brain tissue spectra in norm and in pathology, as well as the intracellular pH variations that have diagnostic and prognostic value.

Keywords:

(31P) MRS

brain energy metabolism

intracellular pH

Authors:

Pronin I.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Zakharova N.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Podoprigora A.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Batalov A.I.

Burdenko Neurosurgical Institute, Moscow, Russia

Tyurina A.N.

Burdenko Neurosurgical Institute, Moscow, Russia

Mertsalova M.P.

Burdenko Neurosurgical Institute, Moscow, Russia

Fadeeva L.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Golanov A.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

ORCID: 0000-0002-0976-4547

Postnov A.A.

Vserossiĭskiĭ tsentr ékstrennoĭ i radiatsionnoĭ meditsiny im. A.M. Nikiforova MChS Rossii, Sankt-Peterburg

Rodionov P.V.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

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