Aminothiols in blood plasma at different subtypes of ischemic stroke

Maksimova M.Yu.; Ivanov A.V.; Nikiforova K.A.; Virus E.D.; Suanova E.T.; Ochtova F.R.; Piradov M.A.; Kubatiev A.A.

doi:https://doi.org/10.17116/jnevro202012008217

Maksimova M.Yu.

Research Center of Neurology

Ivanov A.V.

Institute of General Pathology and Pathophysiology

Nikiforova K.A.

Institute of General Pathology and Pathophysiology

Virus E.D.

Institute of General Pathology and Pathophysiology

Suanova E.T.

Evdokimov Moscow State Medical and Dentistry University

Ochtova F.R.

Evdokimov Moscow State Medical and Dentistry University

Piradov M.A.

Research Center of Neurology

SPIN RSCI: 2860-1689
Scopus AuthorID: 7003731802
ResearcherID: B-4407-2012
ORCID: 0000-0002-6338-0392

Kubatiev A.A.

Institute of General Pathology and Pathophysiology

Aminothiols in blood plasma at different subtypes of ischemic stroke

Authors:

Maksimova M.Yu., Ivanov A.V., Nikiforova K.A., Virus E.D., Suanova E.T., Ochtova F.R., Piradov M.A., Kubatiev A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8‑2): 17‑23

DOI: 10.17116/jnevro202012008217

Read: 2870 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Maksimova MYu, Ivanov AV, Nikiforova KA, et al. . Aminothiols in blood plasma at different subtypes of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8‑2):17‑23. (In Russ.)
https://doi.org/10.17116/jnevro202012008217

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

Close metadata

Abstract:

OBJECTIVE

To evaluate the hemostasis of plasma aminothiols in different subtypes of ischemic stroke (IS).

MATERIAL AND METHODS

The study included 177 patients, aged 62 (55—68) years, admitted in the first 8—24 hours since IS onset. The pathogenetic subtype of IS was clarified according to the results of clinical and instrumental examination by the Trial of ORG 10172 in Acute Stroke Treatment criteria. Determination of the total plasma aminothiols levels, their reduced forms and redox status was performed using the ultra-efficient Acquity H-Class UPLC liquid chromatograph (Waters, CSHA).

RESULTS

Large-artery atherosclerosis was diagnosed in 24.3% patients, cardioembolic stroke in 20.3%, lacunar stroke in 55.4%. Significant differences in total levels of cysteine (Cys), glutathione (Gsh) and homocysteine (Hcy) were identified in patients with different IS subtypes. Patients with large-artery atherosclerosis and lacunar stroke showed the highest level of Hcy, patients with cardioembolic stroke had the lowest levels of Cys and Gsh.

CONCLUSION

Total levels of plasma aminothiols are associated with different subtypes of IS.

Keywords:

ischemic stroke subtypes

aminothiols in blood plasma

Authors:

Maksimova M.Yu.

Research Center of Neurology

Ivanov A.V.

Institute of General Pathology and Pathophysiology

Nikiforova K.A.

Institute of General Pathology and Pathophysiology

Virus E.D.

Institute of General Pathology and Pathophysiology

Suanova E.T.

Evdokimov Moscow State Medical and Dentistry University

Ochtova F.R.

Evdokimov Moscow State Medical and Dentistry University

Piradov M.A.

Research Center of Neurology

SPIN RSCI: 2860-1689
Scopus AuthorID: 7003731802
ResearcherID: B-4407-2012
ORCID: 0000-0002-6338-0392

Kubatiev A.A.

Institute of General Pathology and Pathophysiology

Received:

04.06.2020

Accepted:

27.06.2020

Close metadata

References:

Piradov MA, Tanashyan MM, Maksimova MYu. Insul’t: sovremennye tekhnologii diagnostiki i lecheniya. Pod red. Piradova M.A., Tanashyan M.M., Maksimovoy M.Yu. 3-e izd., dop. i pererab. M: MEDpress-inform; 2018. https://doi.org/10.24421/MP.2018.18.15909
Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41. https://doi.org/10.1161/01.STR.24.1.35
Gimbrone MA Jr, García-Cardeña G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016;118(4):620-636. https://doi.org/10.1161/CIRCRESAHA.115.306301
Godo S, Shimokawa H. Endothelial Functions. Arterioscler Thromb Vasc Biol. 2017;37(9):108-114. https://doi.org/10.1161/ATVBAHA.117.309813
Ho PI, Ortiz D, Rogers E, Shea TB. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res. 2002;70(5):694-702. https://doi.org/10.1002/jnr.10416
Faraci FM, Lentz SR. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke. 2004;35(2):345-347. https://doi.org/10.1161/01.STR.0000115161.10646.67
Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. 2003;57(3-4):145-155. https://doi.org/10.1016/s0753-3322(03)00043-x
Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489-492. https://doi.org/10.1093/jn/134.3.489
Mudd SH, Finkelstein JD, Refsum H, Ueland PM, Malinow MR, Lentz SR, Jacobsen DW, Brattström L, Wilcken B, Wilcken DE, Blom HJ, Stabler SP, Allen RH, Selhub J, Rosenberg IH Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol. 2000;20(7):1704-1706. Review. PMID: 10894806.
Maksimova MY, Ivanov AV, Virus ED, Alexandrin VV, Nikiforova KA, Bulgakova PO, Ochtova FR, Suanova ET, Piradov MA, Kubatiev AA. Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings. Clin Neurol Neurosurg. 2019;183:105393. https://doi.org/10.1016/j.clineuro.2019.105393
Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V. Measurements of acute cerebral infarction: a clinical examination scale. Stroke. 1989;20(7):864-870. https://doi.org/10.1161/01.str.20.7.864
Mahoney FI, Barthel D. Functional evaluation: the Barthel Index. Maryland State Medical Journal. 1965;14:56-61.
van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19(5):604-607. https://doi.org/10.1161/01.str.19.5.604
Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F; Task Force Members. 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34(28):2159-2219. https://doi.org/10.1093/eurheartj/eht151
Guidelines (2013) for managing overweight and obesity in adults. Preface to the Expert Panel Report (comprehensive version which includes systematic evidence review, evidence statements, and recommendations). Obesity (Silver Spring). 2014;22(suppl 2):40. https://doi.org/10.1002/oby.20822
Grundy SM, Balady GJ, Criqui MH, Fletcher G, Greenland P, Hiratzka LF, Houston-Miller N, Kris-Etherton P, Krumholz HM, LaRosa J, Ockene IS, Pearson TA, Reed J, Smith SC Jr, Washington R. When to start cholesterol-lowering therapy in patients with coronary heart disease. A statement for healthcare professionals from the American Heart Association Task Force on Risk Reduction. Circulation. 1997;95(6):1683-1685. PMID: 9118557.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36:67-74. PMID:15618111.
Ivanov AV, Alexandrin VV, Paltsyn AA, Nikiforova KA, Virus ED, Luzyanin BP, Maksimova MY, Piradov MA, Kubatiev AA. Plasma low-molecular-weight thiol/disulphide homeostasis as an early indicator of global and focal cerebral ischaemia. Redox Rep. 2017;22(6):460-466. https://doi.org/10.1080/13510002.2017.1311464
Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288(16):2015-2022. https://doi.org/10.1001/jama.288.16.2015
Gungor L, Polat M, Ozberk MB, Avci B, Abur U. Which Ischemic Stroke Subtype Is Associated with Hyperhomocysteinemia? J Stroke Cerebrovasc Dis. 2018;27(7):1921-1929. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.033
Ahmed S, Bogiatzi C, Hackam DG, Rutledge AC, Sposato LA, Khaw A, Mandzia J, Azarpazhoo MR, Hachinski V, Spence JD. Vitamin B12 deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre. BMJ Open. 2019;9(1):e026564. https://doi.org/10.1136/bmjopen-2018-026564
Hassan A, Hunt BJ, O’Sullivan M, Bell R, D’Souza R, Jeffery S, Bamford JM, Markus HS. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain. 2004;127(Pt 1):212-219. https://doi.org/10.1093/brain/awh023
Shimizu H, Kiyohara Y, Kato I, Kitazono T, Tanizaki Y, Kubo M, Ueno H, Ibayashi S, Fujishima M, Iida M. Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study. Stroke. 2004;35(9):2072-2077. https://doi.org/10.1161/01.STR.0000138022.86509.2d
Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke. 2000;31(5):1069-1075. https://doi.org/10.1161/01.str.31.5.1069
Shimizu H, Kiyohara Y, Kato I, Tanizaki Y, Ueno H, Kimura Y, Iwamoto H, Kubo M, Arima H, Ibayashi S, Fujishima M. Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study. Cerebrovasc Dis. 2002;13(1):9-15. https://doi.org/10.1159/000047739
Wiseman S, Marlborough F, Doubal F, Webb DJ, Wardlaw J. Blood markers of coagulation, fibrinolysis, endothelial dysfunction and inflammation in lacunar stroke versus non-lacunar stroke and non-stroke: systematic review and meta-analysis. Cerebrovasc Dis. 2014;37(1):64-75. https://doi.org/10.1159/000356789
Lehmann MF, Kallaur AP, Oliveira SR, Alfieri DF, Delongui F, de Sousa Parreira J, de Araújo MC, Rossato C, de Almeida JT, Pelegrino LM, Bragato EF, Lehmann AL, Morimoto HK, Lozovoy MA, Simão AN, Kaimen-Maciel DR, Reiche EM Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes. Metab Brain Dis. 2015;30(6):1417-1428. https://doi.org/10.1007/s11011-015-9731-8
Tascilar N, Ekem S, Aciman E, Ankarali H, Mungan G, Ozen B, Unal A Hyperhomocysteinemia as an independent risk factor for cardioembolic stroke in the Turkish population. Tohoku J Exp Med. 2009;218(4):293-300. https://doi.org/10.1620/tjem.218.293
Ashjazadeh N, Fathi M, Shariat A. Evaluation of Homocysteine Level as a Risk Factor among Patients with Ischemic Stroke and Its Subtypes. Iran J Med Sci. 2013;38(3):233-239. PMID: 24174694.