Objective — to perform an experimental psychological study of gender differences in patients with attack-like schizophrenia in the aspect of pathopsychological syndrome. Material and methods. The study included 80 subjects: 40 men and 40 women, aged 18—30 years. The disease duration was <3 years. Patients were examined in remission. Results and conclusion. The major gender differences are manifested in emotional and personal characteristics and self-concepts related with them, as well in the characteristics of communication. It can be assumed that these gender differences are due to a more pronounced presence of an affective component in the structure of endogenous disorders in women which slightly softens the manifestation of negative disorders during the endogenous process.