The aim of this paper was to evaluate factors influencing the efficiency of kinesotherapy in acute ischemic stroke patients during the first rehabilitation stage. Forty patients with stroke, aged between 45 and 74 years, were enrolled in the study. The individual kinesotherapy of 30-45 minutes duration was applied for stroke patients 5 times a week. The efficiency of kinesotherapy was assessed by the modified Functional independence measure scale and the Motor assessment scale before and after treatment. Information about patient's gender, age, weight, brain lesion localization, stroke localization, the depth of lesion, aphasia, number of comorbidities, the beginning of kinesotherapy, patient's motivation and family member participation in the rehabilitation was taken according to a research protocol. The motor function of stroke patients significantly (p<0.05) improved after kinesotherapy sessions at the end of the first stage of rehabilitation. The lower efficiency (p<0.05) of kinesotherapy for acute stroke patients was determined by the brain lesion localization in the left hemisphere and middle cerebral artery, hemiplegia, sensomotor aphasia, and low motivation of the patient.