ECTOPIC ENDOMETRIUM: PROLIFERATIVE ACTIVITY AND APOPTOSIS in PATIENTS WITH PERITONEAL FORM OF GENITAL ENDOMETRIOSIS

V.A. Burlev

Mitotic activity in glandular epithelium and stromal cells of ectopic endometrium at patients with peritoneal form of endometriosis is associated with an expression of apoptosis activators and inhibitors. These data demonstrate a pathogenetic role of proliferative activity and apoptosis in ectopic endometrium in patients with the active form of endometriosis.

Key words: endometriosis, ectopic endometrium, apoptosis (page...)

DIAGNOSTIC VALUE OF ALFA-FETOPROTEIN IN ONCOLOGY, PERINATOLOGY AND NEONATOLOGY (A REVIEW)

T.Yu. Ivanets, M.L. Alekseeva, V.G. Kolodko

The information concerning alfafetoprotein structure and function is presented, as well as informative value of this marker concentration in oncology, obstetrics, neonatology and perinatology is summarizes.

Key words: alpha-fetoprotein, perinatology, neonatology, oncology (page...)

MAMMARY GLAND DEVELOPMENT IN GIRLS (A REVIEW)

L.V. Adamyan, E.A.Bogdanova, E.V. Sibirskaya, I.N. Sorokina

A review regarding anatomy and physiology of the mammary gland and the features of it’ development in girls is presented.

Key words: anatomy, physiology, girls, mammary glands (page ...)

THE TREATMENT OF WOMEN WITH ANDROGENIC DERMATOPATHY

Е.М. Kuznetsova, Т.N. Fedorova, М.А. Gevorkyan, Е.I. Manukhina, S.О. Smirnova

The treatment of women with androgen dermatopathy remains the most difficult problem. The complex approach to the treatment is necessary in accordance with the origin of hyperandrogenia. The hormonal, metabolic and oxidative status of the patients with clinical signs of the hyperandrogenism of the various genesis (PCOS, CAH, the idiopathic form) is discussed. It has been shown that antioxidative therapy of androgen dermatopathy may intensify treatment efficiency.

Key words: hyperandrogenism, dermatopathy, oxidative stress, PCOS, CAH, antioxidative therapy (page ...)

DIAGNOSIS AND TREATMENT OF CHRONIC ENDOMETRITIS IN WOMEN WITH PREVIOUS MISCARRIAGES

Т.А. Pluzhnikova, Е.К. Komarov

159 women with previous miscarriages were investigated and in 105 of them (66%) chronic endometritis was revealed. The immunohistochemical method with monoclonal antibodies to NK cells (CD16+, CD56+), HLA-DR+ and B-lymphocytes (CD20+) was used for diagnosis of chronic endometritis. More than a half of patients had chronic endometritis with autoimmune component (AIC) leading to the increase of antiendometrial antibodies (AEA) concentration in peripheral blood. The patients with chronic endometritis and AIC had significantly delayed secretory transformation of endometrium despite of normal ovarian luteal activity. AEA could have independent influence on hormone-receptor interaction provoking thus morphologic and functional disorders of endometrium. Complex therapy of chronic endometritis led to elimination of AEA and normalization of secretory transformation of endometrium.

Key words: miscarriage, chronic endometritis, endometrial antibodies (page...)

LAPAROSCOPIC HYSTERECTOMY: EFFECT ON SEXUAL FUNCTION

N.M. Podzolkova, Yu.A. Koloda, T.I. Nikitina

The frequency of sexual dysfunction after hysterectomy varies from 10 to 40%.  Effect of laparoscopic hysterectomy on sexual function in women associated with  hormonal  disorders (reduced  libido, arousal, vaginal dryness) that may be associated with damaged vascularisation of  the ovaries after surgery. Orgasm disorders rarely complicated hysterectomy. It is important to discuss with the patients the  issues related to sexual function after surgery to avoid common fears.

Key words: hysterectomy, sexual function (page...)

THE IMPACT OF THROMBOPHILIA ON IVF FAILURE

F.Yu. Gahramanli, F.K. Aliyeva

The aim of the study was to investigate the incidence of thrombophilia in women with IVF failure and to develop the algorithm of patients preparing to next IVF attempt. 81 patients were examined. Genetic forms of thrombophilia were revealed in 75,3%. The use of anticoagulant therapy in IVF programs resulted in high pregnancy rate (50.0%).

Key words: IVF, thrombophilia, LMWH, pregnancy (page... )

THE EFFECT OF UTERINE FIBROIDS ON THE ART OUTCOMES (A REVIEW)

A.E. Martynova, V.Yu. Smolnikova

The influence of fibroids on fertility is poorly understood. Submucosal and intramural fibroids that distort the endometrial cavity have been associated with decreased pregnancy rates following IVF treatment. However, there is uncertainty about the effect of intramural fibroids that do not distort the endometrial cavity on IVF outcomes.

Key words: ART, uterine fibroids, myomectomy, IVF, pregnancy rates (page... )

IN VITRO FERTILIZATION AND MANAGEMENT OF HAEMOSTASIS DISORDERS

A.P. Momot, I.V. Lydina, O.G. Borisov V.A. Elykomov, L.P. Tsyvkina

The association of excess thrombin production and hypofibrinolysis is associated with IVF failures, reducing the chance of pregnancy in 12.1 times. On the basis of selected laboratory parameters three groups of women were formed for therapeutic correction (heparin prophylaxis and/or calf-thigh compression) in the cycles of IVF. The treatment of 98 women with hemostasis disorders resulted in pregnancy rate increase in 4.7 times.

Key words: IVF, pregnancy, risk factors, thrombin, hypofibrinolysis, heparin, prophylaxis, calf-thigh compression (page...)

THE ROLE OF VASCULAR GROWTH FACTORS IN THE DIAGNOSIS OF VARIOUS FORMS OF HYPERTENSION IN PREGNANCY

E.V. Volkova, E.Yu. Lyssuk, L.S. Djokhadze

Preeclampsia remains a major problem in modern medicine. In our study we analyzed the possibility of using angiogenic status in pregnant women with preeclampsia as new markers of the severity of the pathological process, which is necessary for the timely correct diagnosis and optimal treatment.

Key words: preeclampsia, vascular growth factors, optimization tactics (page ...)

PREVENTION OF PREMATURE BIRTH: THE RISK FACTORS

O.I. Sukhorukova

Early check-ups during pregnancy, self-test the pH-balance of the vaginal environment, sanitation and subsequent recovery of normal vaginal flora, the use of preventive antithrombotic therapy in cases of diagnosed hereditary thrombophilia, the use of the Actim Partus test and the adequate tocolytic therapy reduce the incidence of preterm birth and get a higher percentage of live full-term infants.

Key words: premature birth, pH-meters vaginal contents, phosphorylated protein-1, IGFBP-1, hereditary thrombophilia, tocolytic therapy, respiratory distress syndrome (page ...)

THE EFFICIENCY OF MICRO-DOSE HORMONE REPLACEMENT THERAPY IN THE PREVENTION AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN MULTIPAROUS WOMEN

Т.H. Hashaeva, A.B. Gasanova, A.E. Esedova, Z.A. Abusueva, A.G. Gamidova

Femoston ¹/₅ has expressed nonresorptive effect in postmenopausal women, living in the region of a high birth rate. The studied markers of bone remodeling (C-terminal telopeptides in the blood serum and urine, bone alkaline phosphatase and osteocalcin) are sensitive tests for assessing the effectiveness of nonresorptive therapy.

Key words: osteoporosis, bone density, hormone replacement therapy, telopeptides, bone alkaline phosphatase (page... )