PHENOTYPIC CHARACTERISTICS OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH PELVIC PERITONEAL ADHESIONS
V.A. Burlev, E.D. Dubinskaya
200 patients with infertility and pelvic adhesions and 37 patients with infertility without pelvic peritoneum adhesions were studied. The increased extent of adhesive process was associated with more expressed manifestation of undifferentiated connective tissue dysplasia.
Key words: pelvic adhesions, connective tissue (page 8—14)
THE CHANGES IN TESTICULAR PROTEOGLYCANS AND GLYCOSAMINOGLYCANS DURING CHRONIC INTOXICATION INDUCED BY SULFUROUS GAS IN RATS
R.V. Vetoshkin, A.A. Nikolaev, P.V. Loginov
The structure of murine testicular proteoglycans and glycosaminoglycans after chronic intoxication induced by natural gas from Astrakhan condensate deposit was investigated. Chronic intoxication with sulfurous gas was shown to cause the disturbance of electrophoretic profile of proteoglycans. Chromatographic analysis was characterized with increase of sulfated forms resulting in increased proteoglycan acidic fractions.
Key words: proteoglycans, glycosaminoglycans, spermatogenesis, chronic intoxication (page 15—17)
INTRAOPERATIVE BLEEDING:ADHESIONS formation AND METHODS OF THEIR PREVENTION IN MICE
K.S. Mailova, A.A. Osipova, R. Corona, M. Binda, F. Koninckx, L.V. Adamyan
The study demonstrated a high adhesiogenic capacity of blood. The efficacy of pneumoperitoneum with oxygen and nitrous oxide in adhesions prevention after laparoscopic surgery was shown.
Key words: adhesions, blood, laparoscopy, mouse model, pneumoperitoneum (page 18—22)
THE INFLUENCE OF PHOSPHOLIPID TRANSPORT SYSTEM ON THE PARAMETERS OF EMBRYONIC DEVELOPMENT IN VIVO
M.S. Ryabtseva, O. V. Klimova, G.G. Barsegyan
The influence of phospholipid transport system (PLTS) on murine embryonic development was investigated. It was shown that intraperitoneal injection of 5.2 g/kg or 10.25 g/kg PLTS from the 1st to 17th days of gestation , exceeding the therapeutic dose in 10 and 20 times, does not alter the embryos implantation and survival. The dose of 10.25 g/kg leads to fetuses hypertrophy, acceleration of skeleton ossification and causes the head pathology.
Key words: liposomes, embryo toxicity, mouse, in vivo (page 22—26)
THE ANALYSIS OF LIFE QUALITY IN PATIENTS WITH ANDROGENIC DERMOPATHY BEFORE AND AFTER TREATMENT
E.M. Kuznetsova, I.B. Manukhin, M.A. Gevorkyan, E.I. Manukhina
Androgenic dermopathy in women is the permanent stressful factor leading to psycho-emotional reactions, restrictions and reducing quality of life. The analysis of life quality in patients with androgenic dermopathy before and after treatment is presented.
Key words: quality of life, androgenic dermopathy, congenital adrenal hyperplasia, polycystic ovary syndrome (PCOS), idiopathic hyperandrogenism (page 33—37)
HYPERANDROGENISM AND OXIDATIVE STRESS
I.B. Manukhin, T.N. Fedorova, S.О. Smirnova, E.M. Kuznetsova
The hormonal, metabolic and oxidative status of patients with clinical signs of hyperandrogenism of various genesis is presented. It has been supposed that antioxidant therapy of androgenic dermopathy can increase the efficiency of the treatment.
Key words: androgenic dermopathy, oxidative stress, adrenal hyperplasia, polycystic ovary syndrome, idiopathic hyperandrogenism (page 42—45)
Menstrual Cycle-Dependent Problems and progestagen-only contraception
Yu.E. Dobrokhotova, I.I. Grishin
The article considers adverse events, associated with combined oral contraceptives and the issues of contraception without estrogen in women with risk factors, like endometrial hyperplasia; patients with a history of cardiovascular diseases; history of thrombosis, smokers, premenopausal woman. Questions of postpartum contraception.
Key words: estrogen-free pill, progestagens, contraception amone woman with a risk factors, noncontraceptive benfites (page 46—50).
CHROMOSOME PATHOLOGY REVEALED IN ABORTIONS AFTER MISSED ART PREGNANCIES
N.V. Alexandrova, О.А. Doronina, О.R. Baev
The results of cytogenetic testing of first trimester abortions after infertility treatment with the help of ART were analyzed. The rate of chromosome abnormalities in ART and spontaneous pregnancy groups was the same. The association between chromosomal abnormalities and the origin of infertility was also studied.
Кey words: pregnancy, ART, chromosome abnormalities, infertility (page 51—56)
THE ROLE OF UTERINE HEMODYNAMICS IN THE ASSESSMENT OF ENDOMETRIAL RECEPTIVITY
E.Yu. Volkova, I.E. Korneeva, E.S. Silanteva
The different aspects of uterine hemodynamic are presented. The analysis of uterine hemodynamic make allows to predict the pregnancy after IVF.
Key words: uterine hemodynamic, Doppler ultrasonography, thickness of endometrium, IVF (page 57—62)
Twins birth after IVF without stimulation in woman with ovarian depletion
A.A. Smirnova, M.B. Anshina, D.O. Jorlanidze
In 39 years old woman two follicles were aspirated in natural cycle with consequent ICSI of two oocytes. Two 3-days embryos were transferred. Full term pregnancy resulted in twins birth.
Key words: infertility, ovarian depletion (page 63—64).
THE USE OF AROMATASE INHIBITORS IN ART IN WOMEN WITH BREAST CANCER
T.A. Nazarenko, A.A. Parokonnaya, N.Yu. Sharipova
The method of aromatase inhibitors use in stimulation protocols for IVF in patients with breast cancer to preserve their fertility via embryo cryopreservation before chemotherapy is presented. Aromatase inhibitors significantly reduce serum estrogen level without interrupting oogenesis/embryogenesis.
Key words: breast cancer, aromatase inhibitors, fertility preservation (page 72—76)
Poor ovarian response in IVF-programs: a new therapeutic approach
N.M. Podzolkova, Yu.A. Koloda
Modern data regarding poor ovarian response in IVF-programs are presented. The efficiency of new combined recombinant gonadotropin is discussed.
Key words: recombinant LH, recombinant FSH, infertility, IVF, poor response (page 77—82).
THE SCORE SYSTEM OF DELIVERY RISK FOR FERUS AND NEWBORN
A.G. Gunin, A.V. Samoilova, A.B. Demakov
There is no reliable method of assessing the influence of delivery process on newborn condition. Present work suggests the score system to estimate the risk of vaginal delivery for fetus and newborn, which might be tested and discussed.
Key words: delivery, fetus, newborn, risk (page 90—92)
THE IMMUNOLOGICAL THEORY OF PREECLAMPSIA (a review)
O.V. Makarov, E.V. Volkova, I.N. Vinokurova, L.S. Djokhadze
The preeclampsia is one of the most common complications in pregnancy; however, there is still no consensus regarding the trigger of this pathology. The immunological theory as one of the most credible and popular theory of preeclampsia is presented.
Key words: preeclampsia, immunological theory, immunity in physiological pregnancy (page 93—97)
THE ACUTE POINTS OF PREGNANCIES CARE IN WOMEN WITH DIABETES pregnancies (A REVIEW)
O.R. Grigoryan, E.V. Sheremetyeva, E.N. Andreeva
The complications of diabetes mellitus during pregnancy is largely dependent on the degree of metabolic control. Early complications, abortions and congenital malformations are pre-determined with fetal blood glucose level during pregnancy. The childbirth in women with diabetes should not differ from the childbirth in women without metabolic disorders. The breastfeeding should be promoted in patients with impaired glucose metabolism, not only because of the advantages in terms of its composition (immunoglobulins, etc.), but also because of its protective effect against the onset of type 2 diabetes.
Key words: diabetes mellitus, pregnancy (page 98—103)
THE CORRECTION OF MENOPAUSAL DISORDERS IN WOMEN FROM ENDEMIC GOITER REGION
A.G. Gamidova, T.H.-M. Hashaeva, A.E. Esedova, Z.A. Abusueva, A.B. Gasanova
The efficiency and safety of low-dose HRT in women with climacteric disorders in the endemic goiter region was studied. The combination of 1 mg estradiol/2 mg drospirenone and L-thyroxine was shown to be effective and safe in the majority of patients.
Key words: menopause, hypothyroidism, HRT, climacteric disorders (page 110—114)