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Petelina T.I.

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center RAS

Leonovich S.V.

Tomsk National Research Medical Center

Kolupaev V.E.

LLC «Bio-Rad Laboratorii»

Revealed hemoglobinopathy in an adult migrant from South-East Asia in the study of glycated hemoglobin by HPLC

Authors:

Petelina T.I., Leonovich S.V., Kolupaev V.E.

More about the authors

Journal: Laboratory Service. 2021;10(3): 62‑64

DOI: 10.17116/labs20211003162

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Table of contents

REVEALED HEMOGLOBINOPATHY IN AN ADULT MIGRANT FROM SOUTH-EAST ASIA IN THE STUDY OF GLYCATED HEMOGLOBIN BY HPLC
REVEALED HEMOGLOBINOPATHY IN AN ADULT MIGRANT FROM SOUTH-EAST ASIA IN THE STUDY OF GLYCATED HEMOGLOBIN BY HPLC

To cite this article:

Petelina TI, Leonovich SV, Kolupaev VE. Revealed hemoglobinopathy in an adult migrant from South-East Asia in the study of glycated hemoglobin by HPLC. Laboratory Service. 2021;10(3):62‑64. (In Russ.)
https://doi.org/10.17116/labs20211003162

Подписка 2025-2 (Laboratory Service)
МСФ на ЯМ
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A case of HbE in an adult immigrant from Southeast Asia is described and the difficulties encountered in determining the subtype of HbE hemoglobinopathy are documented. The publication of this report aims to draw attention, firstly, to the presence of this rare disease on the territory of the Russian Federation, and secondly, to the possibility of false-negative results in the immunochemical study of glycated hemoglobin as a result of interference with the identified atypical form of hemoglobin.

Keywords:

hemoglobinopathy
HbE
HPLC
glycated hemoglobin

Authors:

Petelina T.I.

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center RAS

Leonovich S.V.

Tomsk National Research Medical Center

Kolupaev V.E.

LLC «Bio-Rad Laboratorii»

Received:

25.06.2021

Accepted:

21.08.2021

List of references:

  1. Weatherall DJ. Thalassemia: the long road from bedside to genome. Nat Rev Genet. 2004;8:625-631.  https://doi.org/10.1038/nrg1406
  2. Dahlawi HA, Zaini RG, Zamzami OM, Alhumyani AF. Hemoglobinopathies among Saudi adults at Taif city, Saudi Arabia. Russian Journal of Hematology and Transfusiology. 2018;2:159-165. (In Russ.). https://doi.org/10.25837/HAT.2018.44..2..006
  3. Mais DD, Gulbranson RD, Keren DF. The range of hemoglobin A2 in hemoglobin E heterozygotes as determined by capillary electrophoresis. Am J Clin Pathol. 2009;132(1):34-38.  https://doi.org/10.1309/AJCPP50JIXXZVLSS
  4. Kunakov YuI, Tyrenko VV, Galomzik NS, et al. The case of hemoglobinopathy E. Onkohematology. 2013;4:51-53. Accessed on 29.06.21. (In Russ.). https://cyberleninka.ru/article/n/sluchay-gemoglobinopatii-e
  5. Library of Variants (LoV). Database for Exploring and Sharing Knowledge. Bio-Rad Laboratories/clinical diagnostics/hemoglobin testing. Accessed on 30.06.21.  https://info.bio-rad.com/cdg-lov
  6. Kiran SS, Aithal S, Belagavi CS. Hemoglobin E Hemoglobinopathy in an Adult from Assam with Unusual Presentation: A Diagnostic Dilemma. Journal of Laboratory Physicians. 2016;8(2):116-119.  https://doi.org/10.4103/0974-2727.180793

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