Intensive care for disseminated intravascular coagulation syndrome (dic-syndrome, coagulopathy) in obstetrics

Close metadata

Recommended articles:

Fibrin monomer in diagnosis of cardiovascular diseases. Russian Cardiology Bulletin. 2024;(4-2):113-120

ABSTRACT The article discusses the main provisions of the clinical guidelines (treatment protocols) the intensive care of disseminated intravascular coagulation syndrome (DIC, coagulopathy) in obstetrics. The main risk factors, possible complications. Particular attention is paid to issues of infusion, transfusion therapy and correction of coagulopathic disorders. Discussed problems of laboratory and clinical diagnosis of DIC, transfusion therapy and the use of blood coagulation factors are discussed.

Keywords:

disseminated intravascular coagulation

intensive theray in obstetrics

Authors:

Artymuk N.V.

kafedra akusherstva i ginekologii #2 Kemerovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

SPIN RSCI: 7348-9673
Scopus AuthorID: 35108913300
ResearcherID: N-2919-2016
ORCID: 0000-0001-7014-6492

Astahov A.A.

FSBEI HE «South-Ural State Medical University», Chelyabinsk, Russia

Belokrinitskaia T.E.

Kafedra akusherstva i ginekologii fakul'teta povysheniia kvalifikatsii i poslediplomnoĭ podgotovki spetsialistov Chitinskoĭ gosudarstvennoĭ meditsinskoĭ akademii

SPIN RSCI: 7823-5179
Scopus AuthorID: 55655694800
ResearcherID: P-9795-2015
ORCID: 0000-0002-5447-4223

Bulanov A.Yu.

St. Petersburg, Russia

Zabolotskikh I.B.

FGBOU VO «Kuban State Medical University» Ministry of Health of Russia, Krasnodar, Russia

SPIN RSCI: 5142-1661
Scopus AuthorID: 6508104506
ResearcherID: O-2705-2014
ORCID: 0000-0002-3623-2546

Kulikov A.V.

SPIN RSCI: 3736-8965
Scopus AuthorID: 35773365600
ResearcherID: C-6924-2016
ORCID: 0000-0002-9980-9226

Matkovsky A.A.

Ovezov A.M.

MONIKI, Moscow, Russia

SPIN RSCI: 9263-8834
Scopus AuthorID: 23474305000
ResearcherID: AAP-3404-2021
ORCID: 0000-0001-7629-6280

Protsenko D.N.

GBUZ «City clinical hospital named after S.S. Yudin» of Moscow health department, Moscow, Russia;
FGBOU VO «Russian national research medical University named after N.I. Pirogov» of Ministry of health of Russia, Moscow, Russia

SPIN RSCI: 1019-8216
Scopus AuthorID: 6603277055
ResearcherID: P-9224-2018
ORCID: 0000-0002-5166-3280

Ronenson A.M.

SBIH TR «Regional Clinical Perinatal Center named E.M. Bakunina», Tver, Russia

SPIN RSCI: 9616-1338
Scopus AuthorID: 56146619300
ResearcherID: K-7232-2014
ORCID: 0000-0002-2468-297X

Riazanova O.V.

FSBEI HE SPbSPMU of the Ministry of Health of Russia, St. Petersburg, Russia

Sinkov S.V.

Kuban State Medical University, Krasnodar, Russia;
Regional Clinical Hospital №2, Krasnodar, Russia

SPIN RSCI: 4413-0869
Scopus AuthorID: 57218212478
ORCID: 0000-0003-4483-4077

Filippov O.S.

Departament razvitiia meditsinskoĭ pomoshchi detiam i sluzhby rodovspomozheniia Ministerstva zdravookhraneniia i sotsial'nogo razvitiia Rossiĭskoĭ Federatsii, Moskva

Shifman E.M.

M.F. Vladimirsky Moscow Regional Research Clinical Institute, Ministry of Health of the Moscow Region, Moscow, Russia

SPIN RSCI: 4582-8494
Scopus AuthorID: 6507655298
ResearcherID: AAY-3981-2020
ORCID: 0000-0002-6113-8498

List of references:

Boral B, Williams D, Boral L. Disseminated Intravascular Coagulation. Am J Clin Pathol. 2016;146(6):670-680.
Levi M, van der Poll T. A short contemporary history of disseminated intravascular coagulation. Semin Thromb Hemost. 2014;40(8):874-880.
Levi M. Pathogenesis and diagnosis of disseminated intravascular coagulation. Int J Lab Hematol. 2018;40(Suppl 1):15-20.
Vaught A. Critical Care for the Obstetrician and Gynecologist: Obstetric Hemorrhage and Disseminated Intravascular Coagulopathy. Obstet Gynecol Clin North Am. 2016;43(4):611-622.
Colling M, Bendapudi P. Purpura Fulminans: Mechanism and Management of Dysregulated Hemostasis. Transfus Med Rev. 2018;32(2):69-76.
Lécuyer H, Borgel D, Nassif X, Coureuil M. Pathogenesis of meningococcal purpura fulminans. Pathog Dis. 2017;75(3).
Perera T, Murphy-Lavoie H. Purpura Fulminans. 2018. Stat Pearls [Internet]. Treasure Island (FL): Available at: https://www.ncbi.nlm.nih.gov/books/NBK532865/
National Clinical Guideline Centre (UK). Blood Transfusion. London: National Institute for Health and Care Excellence (UK); 2015. Available at: https://www.ncbi.nlm.nih.gov/books/NBK11822/
O’Brien K, Shainker S, Lockhart E. Transfusion Management of Obstetric Hemorrhage. Transfus Med Rev. 2018;32(4):249-255.
Flint A, McQuilten Z, Wood E. Massive transfusions for critical bleeding: is everything old new again? Transfus Med. 2018;28(2):140-149.
Woods T, Scott K, Quick A. New Advances in the Care of the Hemorrhaging Patient. Mo Med. 2018;115(5):434-437.
Gatta L, Lockhart E, James A. Blood Products in the Management of Abnormal Placentation. Clin Obstet Gynecol. 2018;61(4):828-840.
Jackson D, DeLoughery T. Postpartum Hemorrhage: Management of Massive Transfusion. Obstet Gynecol Surv. 2018;73(7):418-422.
Tanaka H, Matsunaga S, Yamashita T, Okutomi T, et al. A systematic review of massive transfusion protocol in obstetrics. Taiwan J Obstet Gynecol. 2017;56(6):715-718.
Foster J, Sappenfield J, Smith R, Kiley S. Initiation and Termination of Massive Transfusion Protocols: Current Strategies and Future Prospects. Anesth Analg. 2017;125(6):2045-2055.
Pacheco L, Saade G, Costantine M, Clark S, Hankins G. An update on the use of massive transfusion protocols in obstetrics. Am J Obstet Gynecol. 2016;214(3):340-344.
Lavee O, Kidson-Gerber G. Update on inherited disorders of haemostasis and pregnancy. Obstet Med. 2016;9(2):64-72.
Cohen H, O’Brien P (ed.). Disorders of Thrombosis and Hemostasis in Pregnancy. A Guide to Management. Springer. 2012;252.
Marder VJ, et al. Hemostasis and thrombosis: basic principles and clinical practice. 6th ed. Lippincott Williams & Wilkins, 2013;1566.
Edwards H. Aetiology and treatment of severe postpartum haemorrhage. Dan Med J. 2018;65(3):B5444.
Katz D, Beilin Y. Disorders of coagulation in pregnancy. Br J Anaesth. 2015;115(Suppl 2):75-88.
Bannow B, Konkle B. Inherited Bleeding Disorders in the Obstetric Patient. Transfus Med Rev. 2018;32(4):237-243.
Nyfløt L, Sandven I, Stray-Pedersen B, Pettersen S, et al. Risk factors for severe postpartum hemorrhage: a case-control study. BMC Pregnancy Childbirth. 2017;17(1):17.
Margarido C, Ferns J, Chin V, Ribeiro T, et al. Massive hemorrhage protocol activation in obstetrics: a 5-year quality performance review. Int J Obstet Anesth. 2018. [Epub ahead of print] https://doi.org/10.1016/j.ijoa.2018.10.004
Taylor FJr, Toh C, Hoots W, et al. Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327-1330.
Ding R, Wang Z, Lin Y, Liu B, et al. Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study. Blood Coagul Fibrinolysis. 2018;29(6):551-558.
Wada H, Hasegawa K, Watanabe M. DIC: an update on diagnosis and treatment. Rinsho Ketsueki. 2017;58(5):523-529.
Di Nisio M, Baudo F, Cosmi B, D’Angelo A, et al. Italian Society for Thrombosis and Haemostasis. Diagnosis and treatment of disseminated intravascular coagulation: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res. 2012;129(5):177-184.
Papageorgiou C, Jourdi G, Adjambri E, Walborn A, Patel P, et al. Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies. Clin Appl Thromb Hemost. 2018. [Epub ahead of print]. https://doi.org/10.1177/1076029618806424
Semeraro N, Ammollo C, Semeraro F, et al. Coagulopathy of Acute Sepsis. Semin Thromb Hemost. 2015;41(6):650-658.
Wada H, Matsumoto T, Suzuki K, Imai H, et al. Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy. Thromb J. 2018;16:14.
Chang J. TTP-like syndrome: novel concept and molecular pathogenesis of endotheliopathy-associated vascular microthrombotic disease. Thromb J. 2018;16:20.
Chang JC. Disseminated intravascular coagulation: is it fact or fancy? Blood Coagul Fibrinolysis. 2018;29(3):330-337.
Costello R, Nehring S. Disseminated Intravascular Coagulation (DIC). 2017. Stat Pearls: Available at: https://www.ncbi.nlm.nih.gov/books/NBK441834/
Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38-44.
Kurosawa S, Stearns-Kurosawa D. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014;2(1):65.
Kozek-Langenecker S. Fluids and coagulation. Curr Opin Crit Care. 2015;21(4):285-291.
Duan C, Li T, Liu L. Efficacy of limited fluid resuscitation in patients with hemorrhagic shock: a meta-analysis. Int J Clin Exp Med. 2015;8(7):11645-11656.
Roessler M, Bode K, Bauer M. Fluid resuscitation in hemorrhage. Anaesthesist. 2014;63(10):730-744.
Gillissen A, van den Akker T, Caram-Deelder C, Henriquez D, et al. TeMpOH-1 study group Association between fluid management and dilutional coagulopathy in severe postpartum haemorrhage: a nationwide retrospective cohort study. BMC Pregnancy Childbirth. 2018;18(1):398.
Pohlman T, Fecher A, Arreola-Garcia C. Optimizing transfusion strategies in damage control resuscitation: current insights. J Blood Med. 2018;9:117-133.
Cap A, Pidcoke H, Spinella P, Strandenes G, et al. Damage Control Resuscitation. Mil Med. 2018;183(suppl 2):36-43.
Samuels J, Moore H, Moore E. Damage Control Resuscitation. Chirurgia (Bucur). 2017;112(5):514-523.
Beldowicz B. The Evolution of Damage Control in Concept and Practice. Clin Colon Rectal Surg. 2018;31(1):30-35.
Wikkelsø A, Wetterslev J, Møller A, Afshari A. Thromboelastography (TEG) or rotational thromboelastometry (ROTEM) to monitor haemostatic treatment in bleeding patients: a systematic review with metaanalysis and trial sequential analysis. Anaesthesia. 2017;72(4):519-531.
Wikkelsø A, Wetterslev J, Møller A, Afshari A. Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding. Cochrane Database Syst Rev. 2016;(8):CD007871.
Fahrendorff M, Oliveri R, Johansson P. The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products — a systematic review and metaanalysis. Scand J Trauma Resusc Emerg Med. 2017;25(1):39.
Whiting P, Al M, Westwood M, Ramos I, et al. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015;19(58):1-228.
Cunningham F, Nelson D. Disseminated Intravascular Coagulation Syndromes in Obstetrics. Obstet Gynecol. 2015;126(5):999-1011.
Lippi G, Adcock D, Simundic A, Tripodi A, Favaloro E. Critical laboratory values in hemostasis: toward consensus. Ann Med. 2017;49(6):455-461.
Winter W, Flax S, Harris N. Coagulation Testing in the Core Laboratory. Lab Med. 2017;48(4):295-313.
Solomon C, Collis R, Collins P. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth. 2012;109(6):851-863.
Rossaint R, Bouillon B, Cerny V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016;20(1):100.
Mallett S, Armstrong M. Point-of-care monitoring of haemostasis. Anaesthesia. 2015;70(Suppl 1):73-77.
Levi M, Hunt B. A critical appraisal of point-of-care coagulation testing in critically ill patients. J Thromb Haemost. 2015;13(11):1960-1967.
Fowler A, Perry D. Laboratory monitoring of haemostasis. Anaesthesia. 2015;70(Suppl 1):68-72.
Pacheco L, Saade G, Hankins G. Medical management of postpartum hemorrhage: An update. Semin Perinatol. 2018; [Epub ahead of print]. https://doi.org/10.1053/j.semperi.2018.11.005
Williams B, McNeil J, Crabbe A, Tanaka K. Practical Use of Thromboelastometry in the Management of Perioperative Coagulopathy and Bleeding. Transfus Med Rev. 2017;31(1):11-25.
Benes J, Zatloukal J, Kletecka J. Viscoelastic Methods of Blood Clotting Assessment — A Multidisciplinary Review. Front Med (Lausanne). 2015;2:62.
Gehrie E, Baine I, Booth G. Education Committee of the Academy of Clinical Laboratory Physicians and Scientists. Pathology Consultation on Viscoelastic Studies of Coagulopathic Obstetrical Patients. Am J Clin Pathol. 2016;146(2):149-155.
Curry N, Davenport R, Pavord S, Mallett S, et al. The use of viscoelastic haemostatic assays in the management of major bleeding: a British Society for Haematology Guideline. Br J Haematol. 2018;182(6):789-806.
Kaufner L, Ghantus K, Henkelmann A, Friedrichs U, et al. Haemostatic management in postpartum haemorrhage: Nationwide survey in Germany. Anaesthesist. 2017;66(7):491-499.
Saito S, Uchino S, Hayakawa M, Yamakawa K, et al. Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group. Epidemiology of disseminated intravascular coagulation in sepsis and validation of scoring systems. J Crit Care. 2018;50:23-30.
Thrombosis and hemostasis study group in hematology branch of the Chinese Medical Association. Chinese experts’ consensus on the diagnosis and treatment of disseminated intravascular coagulation (2012 ed.). Chin J Hematol. 2012;33(11):978-979.
Wada H, Thachil J, Di Nisio M, Mathew P, et al. The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013;4:42.
Asakura H, Takahashi H, Uchiyama T, Eguchi Y, et al. DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis. Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thromb J. 2016;14:42.
Lee D, Lee B, Jeung K, Park J, et al. Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma. Medicine (Baltimore). 2018;97(33):11912.
Kobayashi T. Obstetrical disseminated intravascular coagulation score. J Obstet Gynaecol Res. 2014;40:1500-1506.
Yoshihara M, Uno K, Tano S, Mayama M, Ukai M, Kondo S, et al. The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study. Crit Care. 2015 Oct;19:369.
Erez O. Disseminated intravascular coagulation in pregnancy – Clinical phenotypes and diagnostic scores. Thromb Res. 2017;151(Suppl 1):56-60.
Clark S, Romero R, Dildy G, Callaghan W, et al. Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies. Am J Obstet Gynecol. 2016;215(4):408-412.
Nadisauskiene R, Kliucinskas M, Dobozinskas P, Kacerauskiene J. The impact of postpartum haemorrhage management guidelines implemented in clinical practice: a systematic review of the literature. Eur J Obstet Gynecol Reprod Biol. 2014;178:21-26.
McQuilten Z, Crighton G, Brunskill S, Morison JK, et al. Optimal Dose, Timing and Ratio of Blood Products in Massive Transfusion: Results from a Systematic Review. Transfus Med Rev. 2018;32(1):6-15.
Müller M, Straat M, Meijers J, Klinkspoor J, et al. Fresh frozen plasma transfusion fails to influence the hemostatic balance in critically ill patients with a coagulopathy. J Thromb Haemost. 2015;13(6):989-997.
Lancé M, Ninivaggi M, Schols S, Feijge M, et al. Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trial. Vox Sang. 2012;103(1):25-34.
Levy J, Rossaint R, Zacharowski K, Spahn D. What is the evidence for platelet transfusion in perioperative settings? Vox Sang. 2017;112(8):704-712.
Llau J, Acosta F, Escolar G, Fernández-Mondéjar E, et al. Multidisciplinary consensus document on the management of massive haemorrhage (HEMOMAS document). Med Intensiva. 2015;39(8):483-504.
Jones R, de Lloyd L, Kealaher E, Lilley G, et al. Platelet count and transfusion requirements during moderate or severe postpartum haemorrhage. Anaesthesia. 2016;71(6):648-656.
Collis R, Guasch E. Managing major obstetric haemorrhage: Pharmacotherapy and transfusion. Best Pract Res Clin Anaesthesiol. 2017;31(1):107-124.
Shah A, Stanworth S, McKechnie S. Evidence and triggers for the transfusion of blood and blood products. Anaesthesia. 2015;70(Suppl 1):3-5.
Franchini M, Mengoli C, Cruciani M, Bergamini V, et al. Safety and efficacy of tranexamic acid for prevention of obstetric haemorrhage: an updated systematic review and metaanalysis. Blood Transfus. 2018;16(4):329-337.
Shakur H, Beaumont D, Pavord S, Gayet-Ageron A, et al. Antifibrinolytic drugs for treating primary postpartum haemorrhage. Cochrane Database Syst Rev. 2018;2:CD012964.
WOMAN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017;389(10084):2105-2116.
Shaylor R, Weiniger CF, Austin N, Tzabazis A, et al. National and International Guidelines for Patient Blood Management in Obstetrics: A Qualitative Review. Anesth Analg. 2017;124(1):216-232.
Kozek-Langenecker S, Ahmed A, Afshari A, Albaladejo P, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. Eur J Anaesthesiol. 2017;34(6):332-395.
Hunt B, Allard S, Keeling D, Norfolk D, et al. British Committee for Standards in Haematology. A practical guideline for the haematological management of major haemorrhage. Br J Haematol. 2015;170(6):780-788.
Muirhead B, Weiss A. Massive hemorrhage and transfusion in the operating room. Can J Anaesth. 2017;64(9):962-978.
Guidelines for Patient Blood Management in Obstetrics: A Qualitative Review. Anesth Analg. 2017;124(1):216-232.
Knapp J, Hofer S, Lier H. Anesthesiological approach to postpartum hemorrhage. Anaesthesist. 2016;65(3):225-240.
Blood Transfusion in Obstetrics Royal College of Obstetricians and Gynaecologists. Green-top Guideline No. 47. 2015;23.
American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology. 2015;122(2):241-275.
National Clinical Guideline Centre (UK). Blood Transfusion. London: National Institute for Health and Care Excellence (UK), 2015.
Collins P, Abdul-Kadir R, Thachil J. Subcommittees on Women’ s Health Issues in Thrombosis and Haemostasis and on Disseminated Intravascular Coagulation. Management of coagulopathy associated with postpartum hemorrhage: guidance from the SSC of the ISTH. J Thromb Haemost. 2016;14(1):205-210.
Bonnet M, Benhamou D. Management of postpartum haemorrhage. F1000. Res. 2016;5:F1000 Faculty Rev. 1514.
Peyvandi F, Garagiola I, Seregni S. Future of coagulation factor replacement therapy. J Thromb Haemost. 2013;11(Suppl 1):84-98.
Lier H, von Heymann C, Korte W, Schlembach D. Peripartum Haemorrhage: Haemostatic Aspects of the New German PPH Guideline. Transfus Med Hemother. 2018;45(2):127-135.
Affronti G, Agostini V, Brizzi A, Bucci L, et al. The daily-practiced post-partum hemorrhage management: an Italian multidisciplinary attended protocol. Clin Ter. 2017;168(5):307-316.
Ahmadzia H, Phillips J, Katler Q, James A. Tranexamic Acid for Prevention and Treatment of Postpartum Hemorrhage: An Update on Management and Clinical Outcomes. Obstet Gynecol Surv. 2018;73(10):587-594.
Vogel J, Oladapo O, Dowswell T, Gülmezoglu A. Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage. Lancet Glob Health. 2018;6(1):18-19.
Jadon A, Bagai R. Blood transfusion practices in obstetric anaesthesia. Indian J Anaesth. 2014;58(5):629-636.
Meier J. Blood transfusion and coagulation management. Best Pract Res Clin Anaesthesiol. 2016;30(3):371-379.
Kaufman R, Djulbegovic B, Gernsheimer T, Kleinman S, et al. AABB. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med. 2015;162(3):205-213.
Waters J. Role of the massive transfusion protocol in the management of haemorrhagic shock. Br J Anaesth. 2014;113(Suppl 2):3-8.
National Blood Authority. Patient blood management guidelines: module 5-obstetrics and maternity. Canberra ACT (Australia): National Blood Authority; 2015;129.
Prevention and Management of Postpartum Haemorrhage: Green-top Guideline No. 52. BJOG. 2017;124(5):106-149.
Bar-Natan M, Hymes K. Management of Intraoperative Coagulopathy. Neurosurg Clin N Am. 2018;29(4):557-565.
Butwick A, Goodnough L. Transfusion and coagulation management in major obstetric hemorrhage. Curr Opin Anaesthesiol. 2015;28(3):275-284.
Kwon J, MacLaren R. Comparison of Fresh-Frozen Plasma, Four-Factor Prothrombin Complex Concentrates, and Recombinant Factor VIIa to Facilitate Procedures in Critically Ill Patients with Coagulopathy from Liver Disease: A Retrospective Cohort Study. Pharmacotherapy. 2016;36(10):1047-1054.
Brekelmans M, Ginkel K, Daams J, Hutten B, et al. Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and metaanalysis. J Thromb Thrombolysis. 2017;44(1):118-129.
Chai-Adisaksopha C, Hillis C, Siegal D, Movilla R, et al. Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal. A systematic review and metaanalysis. Thromb Haemost. 2016;116(5):879-890.
Refaai M, Goldstein J, Lee M, Durn B, et al. Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal. Transfusion. 2015;55(11):2722-2729.
Goldstein J, Refaai M, Milling TJr, Lewis B, et al. Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial. Lancet. 2015;385(9982):2077-2087.
Johansen M, Wikkelsø A, Lunde J, Wetterslev J, Afshari A. Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non-bleeding patients. Cochrane Database Syst Rev. 2015;(7):CD010555.
Huber A, Raio L, Alberio L, Ghezzi F, Surbek D. Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study. J Perinat Med. 2011;40(1):43-49.
Phillips L, McLintock C, Pollock W, Gatt S, et al. Australian and New Zealand Haemostasis Registry. Recombinant activated factor VII in obstetric hemorrhage: experiences from the Australian and New Zealand Haemostasis Registry. Anesth Analg. 2009;109(6):1908-1915.
Lavigne-Lissalde G, Aya A, Mercier F, Roger-Christoph S, et al. Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial. J Thromb Haemost. 2015;13(4):520-529.
Franchini M, Manzato F, Salvagno G, Lippi G. Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. Blood Coagul Fibrinolysis. 2007;18(7):589-593.
Brenner B, Wiis J. Experience with recombinant-activated factor VII in 30 patients with congenital factor VII deficiency. Hematology. 2007;12(1):55-62.
Shah N, Chong S, Yusoff S, Mazlan M, et al. Recombinant activated factor VII (rFVIIa) in refractory haemorrhage for non-haemophiliacs: an eleven-year single-centre experience. BMC Hematol. 2018;18:34.
Ahonen J. The role of recombinant activated factor VII in obstetric hemorrhage. Curr Opin Anaesthesiol. 2012;25(3):309-314.
Kalina M, Tinkoff G, Fulda G. Massive postpartum hemorrhage: recombinant factor VIIa use is safe but not effective. Del Med J. 2011;83(4):109-113.
Dutta T, Verma S. Rational Use of Recombinant Factor VIIa in Clinical Practice. Indian J Hematol Blood Transfus. 2014;30(2):85-90.
Bolliger D, Mauermann E, Tanaka K. Thresholds for Perioperative Administration of Hemostatic Blood Components and Coagulation Factor Concentrates: An Unmet Medical Need. J Cardiothorac Vasc Anesth. 2015;29(3):768-776.
Knight M, Fitzpatrick K, Kurinczuk J, Tuffnell D. Use of recombinant factor VIIa in patients with amniotic fluid embolism. Anesthesiology. 2012;117:423.
Neb H, Zacharowski K, Meybohm P. Strategies to reduce blood product utilization in obstetric practice. Curr Opin Anaesthesiol. 2017;30(3):294-299.
Godier A, Greinacher A, Faraoni D, Levy J, Samama M. Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH. J Thromb Haemost. 2018;16(1):170-174.
Franchini M, Franchi M, Bergamini V, Montagnana M, Salvagno G, Targher G, Lippi G. The use of recombinant activated FVII in postpartum hemorrhage. Clin Obstet Gynecol. 2010;53(1):219-227.
Zarychanski R, Abou-Setta A, Kanji S, Turgeon A, et al. Canadian Critical Care Trials Group. The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med. 2015;43(3):511-518.
Bain E, Wilson A, Tooher R, Gates S, Davis L, Middleton P. Prophylaxis for venous thromboembolic disease in pregnancy and the early postnatal period. Cochrane Database Syst Rev. 2014;(2):CD001689.
Villani M, Ageno W, Grandone E, Dentali F. The prevention and treatment of venous thromboembolism in pregnancy. Expert Rev Cardiovasc Ther. 2017;15(5):397-402.
Wada H, Matsumoto T, Yamashita Y. Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. J Intensive Care. 2014;2(1):15.
Levi M, Scully M. How I treat disseminated intravascular coagulation. Blood. 2018;131(8):845-854.
Squizzato A, Hunt B, Kinasewitz G, Wada H, et al. Supportive management strategies for disseminated intravascular coagulation. An international consensus. Thromb Haemost. 2016;115(5):896-904.
Venugopal A. Disseminated intravascular coagulation. Indian J Anaesth. 2014;58(5):603-608.
Yatabe T, Inoue S, Sakamoto S, Sumi Y, et al. The anticoagulant treatment for sepsis induced disseminated intravascular coagulation; network metaanalysis. Thromb Res. 2018;171:136-142.
Hayakawa M, Ono K. A summary of the Japan septic disseminated intravascular coagulation study. Acute Med Surg. 2018;5(2):123-128.
Yamakawa K, Umemura Y, Hayakawa M, Kudo D, et al. Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group. Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan. Crit Care. 2016;20(1):229.
Rhodes A, Evans L, Alhazzani W, Levy M, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304-377.
Arulkumaran S, Karoshi M, Keith LG, Lalondé AB, Lynch CB (eds.). A Comprehensive Textbook of Postpartum Hemorrhage An Essential Clinical Reference for Effective Management 2^nd. The Global Library of Women’s Medicine—Sapiens Publishing. 2012;654.
Dahlke J, Mendez-Figueroa H, Maggio L, Hauspurg A, et al. Prevention and management of postpartum hemorrhage: a comparison of 4 national guidelines. Am J Obstet Gynecol. 2015;213(1):76.e1-76.e10.
Haumonté J, Sentilhes L, Macé P, Cravello L, et al. Surgical treatment of postpartum hemorrhage. J Gynecol Obstet Biol Reprod (Paris). 2014;43(10):1083-1103.
Rani P, Begum J. Recent Advances in the Management of Major Postpartum Haemorrhage — A Review. J Clin Diagn Res. 2017;11(2):QE01-QE05.
Henriquez D, Bloemenkamp K, van der Bom J. Management of postpartum hemorrhage: how to improve maternal outcomes? J Thromb Haemost. 2018. Available at: https://www.ncbi.nlm.nih.gov/pubmed/29883040.
Woods T, Scott K, Quick J. New Advances in the Care of the Hemorrhaging Patient. Mo Med. 2018;115(5):434-437.
Working Party: Association of Anaesthetists of Great Britain & Ireland; Obstetric Anaesthetists’ Association; Regional Anaesthesia UK. Regional anaesthesia and patients with abnormalities of coagulation: the Association of Anaesthetists of Great Britain & Ireland The Obstetric Anaesthetists’ Association Regional Anaesthesia UK. Anaesthesia. 2013;68(9):966-972.
Horlocker T, Vandermeuelen E, Kopp S, Gogarten W, et al. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Fourth Edition). Reg Anesth Pain Med. 2018;43(3):263-309.
Delaney M, Wendel S, Bercovitz R, Cid J, et al. Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Transfusion reactions: prevention, diagnosis, and treatment. Lancet. 2016;388(10061):2825-2836.
Osterman JL, Arora S. Blood Product Transfusions and Reactions. Hematol Oncol Clin North Am. 2017;31(6):1159-1170.
Friedman T, Javidroozi M, Lobel G, Shander A. Complications of Allogeneic Blood Product Administration, with Emphasis on Transfusion-Related Acute Lung Injury and Transfusion-Associated Circulatory Overload. Adv Anesth. 2017;35(1):159-173.
Wada H, Asakura H, Okamoto K, et al. Japanese Society of Thrombosis Hemostasis/DIC Subcommittee: expert consensus for the treatment of DIC in Japan. Thromb Res. 2010;125(1):6-11.
Gando S, Saitoh D, Ogura H, et al. Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group, Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey. Crit Care Med. 2008;36(1):145-150.

Close metadata