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A.I. Greben

National Medical Research Center for Rehabilitation and Balneology;
N.I. Pirogov Russian National Research Medical University

P.S. Eremin

National Medical Research Center for Rehabilitation and Balneology

E.Yu. Kostromina

National Medical Research Center for Rehabilitation and Balneology

P.A. Markov

National Medical Research Center for Rehabilitation and Balneology

T.N. Greben

National Medical Research Center for Rehabilitation and Balneology

I.R. Gilmutdinova

National Medical Research Center for Rehabilitation and Balneology

T.V. Konchugova

National Medical Research Center for Rehabilitation and Balneology

Low level laser therapy: molecular mechanisms of anti-inflammatory and regenerative effects

Authors:

A.I. Greben, P.S. Eremin, E.Yu. Kostromina, P.A. Markov, T.N. Greben, I.R. Gilmutdinova, T.V. Konchugova

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2023;100(2): 61‑68

DOI: 10.17116/kurort202310002161

Views: 1510

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LOW LEVEL LASER THERAPY: MOLECULAR MECHANISMS OF ANTI-INFLAMMATORY AND REGENERATIVE EFFECTS
LOW LEVEL LASER THERAPY: MOLECULAR MECHANISMS OF ANTI-INFLAMMATORY AND REGENERATIVE EFFECTS

To cite this article:

Greben AI, Eremin PS, Kostromina EYu, Markov PA, Greben TN, Gilmutdinova IR, Konchugova TV. Low level laser therapy: molecular mechanisms of anti-inflammatory and regenerative effects. Problems of Balneology, Physiotherapy and Exercise Therapy. 2023;100(2):61‑68. (In Russ.)
https://doi.org/10.17116/kurort202310002161

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Laser therapy as a physiotherapeutic method has been successfully used for a long time in the treatment of various pathologies, but the action mechanisms of low level laser therapy (LLLT) remain understudied.

OBJECTIVE

To perform the analysis of published results of LLLT investigations, to describe the physical principles of photobiomodulation, its action mechanisms on various cells and tissues, therapeutic intervention and efficiency of the technique.

MATERIAL AND METHODS

The search of articles was done for the period from 2014 to 2022. The preference was given to the articles for the last 5 years in the PubMed database depending on keywords: low level laser therapy, photobiomodulation, exosomes, monocytes, macrophages.

RESULTS AND DISCUSSION

This article represents the current conceptions about the action mechanisms and reproduced effects of low level laser therapy, the photobiomodulation influence on the inflammation and reparative processes in human body by intervention on cells and their signal pathways. The discussion of research results and probable causes of conflicting data are performed, as well as the efficacy assessment of laser irradiation in different conditions and diseases is made.

CONCLUSION

Laser therapy has certain variety of advantages, among which: non-invasiveness and availability, long-term service of equipment, stable intensity of light radiation and the ability to use in various wavelength ranges. The technique efficacy was proven for a large number of diseases. However, for the successful application of photobiomodulation in clinical practice in current evidence-based medicine, additional investigations are necessary to determine the best dosimetric radiation parameters, as well as further study of action mechanisms on various human cells and tissues.

Keywords:

laser therapy
photobiomodulation
low level laser therapy
regenerative medicine
monocytes
macrophages
spinal cord injury
bone defects

Authors:

A.I. Greben

National Medical Research Center for Rehabilitation and Balneology;
N.I. Pirogov Russian National Research Medical University

P.S. Eremin

National Medical Research Center for Rehabilitation and Balneology

E.Yu. Kostromina

National Medical Research Center for Rehabilitation and Balneology

P.A. Markov

National Medical Research Center for Rehabilitation and Balneology

T.N. Greben

National Medical Research Center for Rehabilitation and Balneology

I.R. Gilmutdinova

National Medical Research Center for Rehabilitation and Balneology

T.V. Konchugova

National Medical Research Center for Rehabilitation and Balneology

Received:

03.11.2022

Accepted:

16.11.2022

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