Therapy of mental disorders in patients with hematological malignancies

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OBJECTIVE

To assess the possibilities of therapy with minimal effective doses (MED) of psychotropic drugs for mental disorders (MD) that manifest during the treatment of hematological malignancies (HM).

MATERIAL AND METHODS

A prospective study was conducted at the National Medical Research Center for Hematology of the Russian Ministry of Health (Moscow), which included 204 (39.4%) men and 314 (60.6%) women (518 patients in total), aged 17 to 83 years (median 45 years), with various HM, in which the manifestation of MD occurred during the treatment of the underlying disease. To minimize the side-effects of psychotropic drugs and given the relatively mild level of MD, psychopharmacotherapy of patients was carried out mainly at MED. The severity of MD, manifested in patients, was assessed by the illness severity scale of the Clinical Global Impression (CGI) scale, and the effectiveness of the treatment was assessed by the improvement scale (CGI-I).

RESULTS

Mainly mild (188, 36%) and moderately pronounced (270, 52%) MD were noted in patients with HM during the treatment of the underlying disease. Severe psychopathological disorders (60, 12%) were observed much less often. Because of psychopharmacotherapy with MED, patients experienced a very significant (97, 19%) and significant improvement (354, 68%) of their mental state, less often the improvement was regarded as minimal (67, 13%). Therefore, almost all patients showed a stable relief of MD; in 87% (95% CI 84—90) of patients, this improvement was significant.

CONCLUSION

The tactics of treatment MD that manifest in patients with HM with MED of psychotropic drugs turned out to be therapeutically effective according to the results of the assessment on CGI scales.

Keywords:

psychopharmacotherapy

minimum effective doses

psychotropic drugs

hematological malignancies

overall clinical impression scale (CGI)

frequency analysis

Authors:

D.E. Vybornykh

National Medical Research Center for Hematology

ORCID: 0000-0001-7506-4947

S.V. Ivanov

Mental Health Research Center

ORCID: 0000-0001-9532-7150

E.G. Gemdzhian

National Medical Research Center for Hematology

ORCID: 0000-0002-8357-977X

L.V. Esina

National Medical Research Center for Hematology;
Sechenov First Moscow State Medical University

ORCID: 0000-0001-7253-5694

T.V. Gaponova

National Medical Research Center for Hematology

ORCID: 0000-0002-9684-5045

Received:

07.07.2023

Accepted:

21.01.2024

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