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Fedin A.I.

Pirogov Russian National Research Medical University

The glymphatic system in the brain — neurobiology and clinical pathology

Authors:

Fedin A.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5): 13‑19

DOI: 10.17116/jnevro202312305113

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THE GLYMPHATIC SYSTEM IN THE BRAIN — NEUROBIOLOGY AND CLINICAL PATHOLOGY
THE GLYMPHATIC SYSTEM IN THE BRAIN — NEUROBIOLOGY AND CLINICAL PATHOLOGY

To cite this article:

Fedin AI. The glymphatic system in the brain — neurobiology and clinical pathology. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5):13‑19. (In Russ.)
https://doi.org/10.17116/jnevro202312305113

 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Given new information about the neurobiology of the processes of removal of waste products of the brain, consisting of the lymphatic vessels into the dura and the glial-lymphatic (glymphatic) system. The role of astrocytes and water-conducting channels located on them in cell membranes formed by the protein aquaporin-4 is emphasized. The connection between the functioning of the glymphatic system and the slow phase of sleep is discussed. Possible mechanisms for the development of cognitive impairments in violation of the function of the glymphatic system and a delay in the elimination of β-amyloid are shown. Directions of pathogenetic therapy are given.

Keywords:

glymphatic system
protein aquaporin-4
β-amyloid
cognitive impairment
Cortexin

Authors:

Fedin A.I.

Pirogov Russian National Research Medical University

Received:

16.03.2023

Accepted:

28.03.2023

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