Intraoperative optical coherence tomography in vitreoretinal surgery

Close metadata

Recommended articles:

Long-term outcomes of treating rhegmatogenous retinal detachment with macular hole using platelet-rich blood plasma. Russian Annals of Ophthalmology. 2023;(2):6-10

Horseshoe retinal tear: factors that determine the risk of developing rhegmatogenous retinal detachment. Russian Annals of Ophthalmology. 2023;(4):20-25

Pathogenetic role of multifunctional protein alpha-2-macroglobulin and its activity in tears and serum in age-related macular degeneration and proliferative diabetic retinopathy. Russian Annals of Ophthalmology. 2023;(6):26-32

This article reviews literature on the use of intraoperative optical coherence tomography (iOCT) in vitreoretinal surgery, describes the historical aspects of the development of this technology from portable devices to optical coherence tomographs integrated into the surgical microscope, considers the advantages, limitations and disadvantages of this technology, which are now becoming obvious due to the accumulated experience. The review also explores the prospects for the development of iOCT and possible ways to solve its problems. In addition, the review presents and systematizes clinical findings that can be revealed with iOCT in such diseases as rhegmatogenous retinal detachment, complications of proliferative diabetic retinopathy, macular pathology, etc.

Keywords:

intraoperative optical coherence tomography

vitreoretinal surgery

rhegmatogenous retinal detachment

proliferative diabetic retinopathy

epimacular fibrosis

penetrating macular hole

Authors:

Yu.N. Yusef

Krasnov Research Institute of Eye Diseases;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-4043-456X

D.V. Petrachkov

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0003-4757-5584

Received:

30.09.2022

Accepted:

17.10.2022

List of references:

Ung C, Miller JB. Intraoperative Optical Coherence Tomography in Vitreoretinal Surgery. Semin Ophthalmol. 2019;34(4):312-316. https://doi.org/10.1080/08820538.2019.1620811
Ringel MJ, Tang EM, Tao YK. Advances in multimodal imaging in ophthalmology. Ther Adv Ophthalmol. 2021;13:25158414211002400. Published 2021 Mar 19. https://doi.org/10.1177/25158414211002400
Benda T, Studený P. Intraoperative optical coherence tomography — available technologies and possibilities of use. A review. Cesk Slov Oftalmol. 2022 Winter;2(Ahead of Print):1001-1010.
Avetisov KS, Bol’shunov AV, Avetisov SE, Yusef YuN, Ivanov MN, Sobol EN, Sakalova ED. Hybrid (femtosecond laser-assisted) phaco surgery and the state of the macula. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2017;4(133):97-102. (In Russ.). https://doi.org/10.17116/oftalma2017133497-102
Dayani PN, Maldonado R, Farsiu S, Toth CA. Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery. Retina. 2009;29(10):1457-1468. https://doi.org/10.1097/IAE.0b013e3181b266bc
Branchini LA, Gurley K, Duker JS, Reichel E. Use of handheld intraoperative spectral-domain optical coherence tomography in a variety of vitreoretinal diseases. Ophthalmic Surg Lasers Imaging Retina. 2016;47(1):49-54. https://doi.org/10.3928/23258160-20151214-07
Joos KM, Shen JH. Miniature real-time intraoperative forward-imaging optical coherence tomography probe. Biomed Opt Express. 2013;4(8):1342-1350. https://doi.org/10.1364/BOE.4.001342
Asami T, Terasaki H, Ito Y, Sugita T, Kaneko H, Nishiyama J, Namiki H, Kobayashi M, Nishizawa N. Development of a fiber-optic optical coherence tomography probe for intraocular use. Invest Ophthalmol Vis Sci. 2016;57(9): OCT568. https://doi.org/10.1167/iovs.15-18853
Carrasco-Zevallos OM, Viehland C, Keller B, Draelos M, Kuo AN, Yoth CA, Izatt JA. Review of intraoperative optical coherence tomography: technology and applications [Invited]. Biomed Opt Express. 2017;8(3):1607-1637. https://doi.org/10.1364/BOE.8.001607
Bayborodov YaV, Balashevich LI. Microinvasive surgical treatment of macular hole of stage I without vitrectomy under the intra-operative OCT control. Fyodorov Journal of Ophthalmic Surgery = Oftal’mokhirurgiya. 2017;(1): 53-58. (In Russ.). https://doi.org/10.25276/0235-4160-2017-1-53-58
Ahronovich EZ, Simaan N, Joos KM. A Review of Robotic and OCT-Aided Systems for Vitreoretinal Surgery. Adv Ther. 2021;38(5):2114-2129. https://doi.org/10.1007/s12325-021-01692-z
Ehlers JP, Dupps WJ, Kaiser PK, Goshe J, Singh RP, Petkovsek D, Srivastava SK. The prospective intraoperative and perioperative ophthalmic imaging with optical coherence tomography (PIONEER) study: 2-year results. Am J Ophthalmol. 2014;158(5):999-1007. https://doi.org/10.1016/j.ajo.2014.07.034
Ray R, Baranano DE, Fortun JA, Schwent BJ, Cribbs BE, Bergstrom CS, Hubbard GB, Srivastava SK. Intraoperative microscope-mounted spectral domain optical coherence tomography for evaluation of retinal anatomy during macular surgery. Ophthalmology. 2011;118(11):2212-2217. https://doi.org/10.1016/j.ophtha.2011.04.012
Binder S, Falkner-Radler CI, Hauger C, Matz H, Glittenberg C. Feasibility of intrasurgical spectral-domain optical coherence tomography. Retina. 2011;31(7):1332-1336. https://doi.org/10.1097/IAE.0b013e3182019c18
Ehlers JP, Tao YK, Farsiu S, Maldonado R, Izatt JA, Toth CA. Visualization of real-time intraoperative maneuvers with a microscope-mounted spectral domain optical coherence tomography system. Retina. 2013;33(1):232-236. https://doi.org/10.1097/IAE.0b013e31826e86f5
Hahn P, Migacz J, O’Connell R, Maldonado RS, Izatt JA, Toth CA. The use of optical coherence tomography in intraoperative ophthalmic imaging. Ophthalmic Surg Lasers Imaging. 2011;42(suppl):85-94. https://doi.org/10.3928/15428877-20110627-08
Zakir R, Iqbal K, Hassaan Ali M, Mirza UT, Mahmood K, Riaz S, Hashmani N. The outcomes and usefulness of Intraoperative Optical Coherence Tomography in vitreoretinal surgery and its impact on surgical decision making. Rom J Ophthalmol. 2022;66(1):55-60. https://doi.org/10.22336/rjo.2022.12
Ehlers JP, Modi YS, Pecen PE, Goshe J, Dupps WJ, Rachitskaya A, Sharma S, Yuan A, Singh R, Kaiser PK, Reese JL, Calabrise C, Watts A, Srivastava SK. The DISCOVER Study 3-Year Results: Feasibility and Usefulness of Microscope-Integrated Intraoperative OCT during Ophthalmic Surgery. Ophthalmology. 2018;125(7):1014-1027. https://doi.org/10.1016/j.ophtha.2017.12.037
Ehlers JP, Kaiser PK, Srivastava SK. Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study. Br J Ophthalmol. 2014;98(10):1329-1332. https://doi.org/10.1136/bjophthalmol-2014-305294
Ehlers JP, Goshe J, Dupps WJ, Kaiser PK, Singh RP, Gans R, Eisengart J, Srivastava SK. Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER study RESCAN results. JAMA Ophthalmol. 2015;133(10):1124-1132. https://doi.org/10.1001/jamaophthalmol.2015.2376
Runkle A, Srivastava SK, Ehlers JP. Microscope-Integrated OCT Feasibility and Utility With the EnFocus System in the DISCOVER Study. Ophthalmic Surg Lasers Imaging Retina. 2017;48(3):216-222. https://doi.org/10.3928/23258160-20170301-04
Ehlers JP, Srivastava SK, Feiler D, Noonan AI, Rollins AM, Tao YK. Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback. PLoS One. 2014;9(8):e105224. https://doi.org/10.1371/journal.pone.0105224
Carrasco-Zevallos OM, Keller B, Viehland C, Shen L, Seider MI, Izatt JA, Toth CA. Optical coherence tomography for retinal surgery: perioperative analysis to real-time four-dimensional image-guided surgery. Invest Ophthalmol Vis Sci. 2016;57(9):OCT37-50. https://doi.org/10.1167/iovs.16-19277
Gabr H, Chen X, Zevallos-Carrasco OM, Viehland C, Dandrige A, Sarin N, Mahmoud TH, Vajzovic L, Izatt JA, Toth CA. Visualization from intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for complications of proliferative diabetic retinopathy. Retina. 2018;38(suppl 1):110-120. https://doi.org/10.1097/IAE.0000000000002021
Carrasco-Zevallos OM, Keller B, Viehland C, Shen L, Waterman G, Todorich B, Shieh C, Hahn P, Farsiu S, Kuo AN, Toth CA, Izatt JA. Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography. Sci Rep. 2016;6:31689. Published 2016 Aug 19. https://doi.org/10.1038/srep31689
Tang EM, El-Haddad MT, Patel SN, Tao YK. Automated instrument-tracking for 4D video-rate imaging of ophthalmic surgical maneuvers. Biomed Opt Express. 2022;13(3):1471-1484. https://doi.org/10.1364/BOE.450814
El-Haddad MT, Tao YK. Automated stereo vision instrument tracking for intraoperative OCT guided anterior segment ophthalmic surgical maneuvers. Biomed Opt Express. 2015;6(8):3014-3031. https://doi.org/10.1364/BOE.6.003014
Leisser C, Hackl C, Hirnschall N, Luft N, Döller B, Draschl P, Rigal K, Findl O. Visualizing macular structures during membrane peeling surgery with an intraoperative spectral-domain optical coherence tomography device. Ophthalmic Surg Lasers Imaging Retina. 2016;47(4):328-332. https://doi.org/10.3928/23258160-20160324-04
Falkner-Radler CI, Glittenberg C, Gabriel M, Binder S. Intrasurgical microscope-integrated spectral domain optical coherence tomography-assisted membrane peeling. Retina. 2015;35(10):2100-2106. https://doi.org/10.1097/IAE.0000000000000596
Aznabaev BM, Dibaev TI, Mukhamadeev TR, Bagdanurova AR. Intraoperative optical coherence tomography in the study of microstructural changes of posterior segment of the eye during vitrectomy. Medicinskij vestnik Bashkortostana. 2018;1(73):19-22. Accessed 05.07.22 (In Russ.). https://cyberleninka.ru/article/n/intraoperatsionnaya-opticheskaya-kogerentnaya-tomografiya-v-izuchenii-mikrostrukturnyh-izmeneniy-zadnego-otdela-glaza-pri
Bayborodov YaV. The concept of the foveola anatomical reconstruction in the surgical treatment of full-thickness macular tears using intraoperative oct control. Ophthalmology Journal = Oftal’mologicheskie vedomosti. 2017;10(3): 12-17 (In Russ.). https://doi.org/10.17816/OV10312-17
Aznabaev BM, Mukhamadeev TR, Dibaev TI. Intraoperative oct imaging in anterior and posterior eye segment surgery. Medicinskij vestnik Bashkortostana. 2016;1(61):151-154. Accessed 05.07.22 (In Russ.). https://cyberleninka.ru/article/n/intraoperatsionnaya-okt-vizualizatsiya-v-hirurgii-perednego-i-zadnego-otrezka-glaza
Tuifua TS, Sood AB, Abraham JR, Srivastava SK, Kaiser PK, Sharma S, Rachitskaya A, Singh RP, Reese J, Ehlers JP. Epiretinal Membrane Surgery Using Intraoperative OCT-Guided Membrane Removal in the DISCOVER Study versus Conventional Membrane Removal. Ophthalmol Retina. 2021; 5(12):1254-1262. https://doi.org/10.1016/j.oret.2021.02.013
Ehlers JP, Xu D, Kaiser PK, Singh RP, Srivastava SK. Intrasurgical dynamics of macular hole surgery: an assessment of surgery-induced ultrastructural alterations with intraoperative optical coherence tomography. Retina. 2014; 34(2):213-221. https://doi.org/10.1097/IAE.0b013e318297daf3
Ehlers JP, Tam T, Kaiser PK, Martin DF, Smith GM, Srivastava SK. Utility of intraoperative optical coherence tomography during vitrectomy surgery for vitreomacular traction syndrome. Retina. 2014;34(7):1341-1346. https://doi.org/10.1097/IAE.0000000000000123
Lytvynchuk LM, Glittenberg CG, Ansari-Shahrezaei S, Binder S. Intraoperative optical coherence tomography assisted analysis of pars Plana vitrectomy for retinal detachment in morning glory syndrome: a case report. BMC Ophthalmol. 2017;17(1):134. https://doi.org/10.1186/s12886-017-0533-0
Lee LB, Srivastava SK. Intraoperative spectral-domain optical coherence tomography during complex retinal detachment repair. Ophthalmic Surg Lasers Imaging. 2011;42 Online:e71-74. https://doi.org/10.3928/15428877-20110804-05
Muni RH, Kohly RP, Charonis AC, Lee TC. Retinoschisis detected with handheld spectral-domain optical coherence tomography in neonates with advanced retinopathy of prematurity. Arch Ophthalmol. 2010;128(1):57-62. https://doi.org/10.1001/archophthalmol.2009.361
Rachitskaya AV, Yuan A, Marino MJ, Reese J, Ehlers JP. Intraoperative OCT imaging of the Argus II retinal prosthesis system. Ophthalmic Surg Lasers Imaging Retina. 2016;47(11):999-1003. https://doi.org/10.3928/23258160-20161031-03
Gregori NZ, Lam BL, Davis JL. Intraoperative Use of Microscope-Integrated Optical Coherence Tomography for Subretinal Gene Therapy Delivery. Retina. 2019;39(suppl 1):9-12. https://doi.org/10.1097/IAE.0000000000001646
Xue K, Groppe M, Salvetti AP, MacLaren RE. Technique of retinal gene therapy: delivery of viral vector into the subretinal space. Eye (Lond). 2017; 31(9):1308-1316. https://doi.org/10.1038/eye.2017.158
Westenskow PD, Kurihara T, Bravo S, Feitelberg D, Sedillo ZA, Aguilar E, Friedlander M. Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension. J Vis Exp. 2015;(95):52247. https://doi.org/10.3791/52247
Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y, Terada M, Nomiya Y, Tanishima S, Nakamura M, Kamao H, Sugita S, Onishi A, Ito T, Fujita K, Kawamata S, Go MJ, Shinohara C, Hata KI, Sawada M, Yamamoto M, Ohta S, Ohara Y, Yoshida K, Kuwahara J, Kitano Y, Amano N, Umekage M, Kitaoka F, Tanaka A, Okada C, Takasu N, Ogawa S, Yamanaka S, Takahashi M. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017;376(11):1038-1046. https://doi.org/10.1056/NEJMoa1608368
Pfau M, Michels S, Binder S, Becker MD. Clinical experience with the first commercially available intraoperative optical coherence tomography system. Ophthalmic Surg Lasers Imaging Retina. 2015;46(10):1001-1008. https://doi.org/10.3928/23258160-20151027-03
Ehlers JP, Uchida A, Srivastava SK. Intraoperative optical coherence tomography-compatible surgical instruments for real-time image-guided ophthalmic surgery. Br J Ophthalmol. 2017;101(10):1306-1308. https://doi.org/10.1136/bjophthalmol-2017-310530
Rico-Jimenez JJ, Hu D, Tang EM, Oguz I, Tao YK. Real-time OCT image denoising using a self-fusion neural network. Biomed Opt Express. 2022;13(3): 1398-1409. https://doi.org/10.1364/BOE.451029

Close metadata