Evolution of dry eye disease diagnostics

Close metadata

Recommended articles:

Therapeutic hygiene of eyelids in dry eye disease prior to cataract phacoemulsification. Russian Annals of Ophthalmology. 2023;(1):46-54

Modern possibilities of pathogenetically oriented therapy for dry eye syndrome. Russian Annals of Ophthalmology. 2023;(2):95-103

Neuropathic pain in dry eye syndrome. Part 1. Pathophysiological mechanisms of pain formation. Russian Annals of Ophthalmology. 2023;(4):93-99

Neuropathic pain in dry eye syndrome. Part 2. Clinical picture, diagnosis and treatment. Russian Annals of Ophthalmology. 2023;(4):100-106

Acaricidal therapy in chronic demodex blepharitis and meibomian gland dysfunctions. Russian Annals of Ophthalmology. 2023;(5):36-42

Risk factors, clinical features and indications for treatment of dry eye disease at a young age. Russian Annals of Ophthalmology. 2023;(6):94-100

Kinetics of mucosal blood flow in 3D modeling of the gingival contour around dental implants after bone reconstruction of the alveolar ridge in the lateral part of the jaws. Stomatology. 2023;(2):25-32

Molecular genetic features of meningiomas. Burdenko's Journal of Neurosurgery. 2023;(4):101-106

Laser Doppler flowmetry in risk assessment of trophic abnormalities in adipose-cutaneous flaps of lateral regions of the face and neck during rejuvenation surgery in smokers. Plastic Surgery and Aesthetic Medicine. 2023;(4):37-43

This article reviews modern functional and instrumental examination methods included in the diagnostic algorithm for dry eye disease. The described methods can serve as an objective criterion for the effectiveness of the therapy.

Keywords:

dry eye syndrome

tear film

tearscopy

impression cytology

laser scanning confocal microscopy

laser Doppler flowmetry

terahertz reflectometry

genetic studies

Authors:

T.N. Safonova

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0002-4601-0904

G.V. Zaitseva

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-8575-3076

N.P. Kintyukhina

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0002-2740-2793

Received:

01.03.2023

Accepted:

03.03.2023

List of references:

Sjögren H. Zur Kenntnis der Keratoconjunctivitis Sicca (Keratitis filiformis bei Hypofunktion der Tranendrusen). Acta Ophthalmol. 1933(Suppl II): 1-151. (In German).
Holly FJ, Lemp MA. Tear physiology and dry eyes. Survey of Ophthalmology. 1977;22:69-75.
Holly FJ. Physical Chemistry of the Normal and Disorderad Tear Film. Trans Ophthal Soc UK (1962). 1985;104(Pt 4):374-380.
McDonald JE, Brubaker S. Meniscus-induced thinning of tear films. Am J Ophthalm. 1971;72(1):139-146.
Norn MS. Dissication of the precorneal film. Corneal wetting time. Acta Ophthalmol. 1969;47:865-880. https://doi.org/10.1111/j.1755-3768.1969.tb03711.x
Craig JP, Tomlinson A. Importance of the lipid layer in human tear filmstability and evaporation. Optom Vis Scie. 1997;74:8-13. https://doi.org/10.1097/00006324-199701000-00014
Egorova GB, Novikov IA, Mitichkina TS. Perfection and assessment of the possibilities of the method of tiascopy. Vestnik oftal’mologii. 2011;127(6): 35-40. (In Russ.).
Safonova TN, At’kova EL, Kintyukhina NP, Reznikova LV. Modern methods of evaluating the morphological and functional state of the eyelids in chronic blepharitis. Vestnik oftal’mologii. 2018;134(5):276-281. (In Russ.). https://doi.org/10.17116/oftalma2018134051276
Fedorov AA. Morphological basics of scientific research in ophthalmology. Vestnik oftal’mologii. 2013;129(5):10-21. (In Russ.).
Thatcher RW, Darougar S, Jones BR. Conjunctival impression cytology. Arch Ophthalmol. 1977;95:678-968. https://doi.org/10.1001/archopht.1977.04450040144022
Safonova TN, Kintyukhina NP, Sidorov VV, Gladkova OV, Reyn ES. Microcirculatory blood and lymph flow examination in eyelid skin by laser Doppler flowmetry. Vestnik oftal’mologii. 2017;133(3):16-21. (In Russ.). https://doi.org/10.17116/oftalma2017133316-21
Safonova TN, Kintyukhina NP, Sidorov VV, Gladkova OV. Laser doppler flowmetry in assessing the effectiveness of treatment of chronic demodex blefaritis. Rossijskij oftal’mologicheskij zhurnal. 2017;10(2):62-66. (In Russ.).
Safonova TN, Kintyukhina NP, Yartsev VD. Morphofunctional substantiation of repeated invasive treatment of chronic blepharitis. Vestnik oftal’mologii. 2021;137(1):21-27. (In Russ.). https://doi.org/10.17116/oftalma202113701121
Safonova TN, Kintyukhina NP. Involutional blepharitis: modern approaches to diagnostic and treatment. Vestnik oftal’mologii. 2018;134(1):43-47. (In Russ.). https://doi.org/10.17116/oftalma2018134143-47
Lemp MA. Report of the National Eye Institute Industry/Industry workshop on Clinical Trails in Dry Eyes. CLAO J. 1995;21(4):221-232.
Van Haertingen NJ. Clinical biochemistry of tears. Surv Ophthalmol. 1981; 26:84-96. https://doi.org/10.1016/0039-6257(81)90145-4
Nasnikova IYu, Markosyan AG, Kharlap SI, Safonova TN, Ermakov NV, Eksarenko OV, Vashkulatova EA. Sizes and ratios of structural parameters of the lacrimal gland according to the results of spatial ultrasound digital examination in normal and pathological conditions. Kremlevskaya meditsina. Klinicheskij vestnik. 2014;1:92-98. (In Russ.).
Safonova TN, Kharlap SI, Eksarenko OV. Ultrasound predictors of dry eye syndrome in sarcoidosis. Journal of Radiology and Nuclear Medicine. 2019; 100(4):186-191. (In Russ.). https://doi.org/10.20862/0042-4676-2019-100-4-186-191
Safonova TN, Vasilyev VI, Likhvantseva VG. Sindrom Shegrena. Rukovodstvo dlya vrachej. M.: Izdatel’stvo Moskovskogo universiteta; 2013. (In Russ.).
Vasilyev VI, Safonova TN, Socol EV, et al. Diagnosis of IgG4 associated ophthalmic disease in a group of patients with various lesions of the eyes and orbits. Terapevticheskij arkhiv. 2018;90(5):61-71. (In Russ.). https://doi.org/10.26442/terarkh201890561-71
Thatcher RW, Darougar S, Jones BR. Conjunctival impression cytology. Arch Ophthalmol. 1977;95:678-68. https://doi.org/10.1001/archopht.1977.04450040144022
Brignole-Baudouin F, Ott AC, Warnet JM, Baudouin C. Flow cytometry in conjunctival impression cytology: A new tool for exploring ocular surface pathologies. Exp Eye Res. 2004;78:473-481. https://doi.org/10.1016/j.exer.2003.08.005
Nelson JD. Impression cytology. Cornea. 1988;7:71-81.
Safonova TN, Fedorov AA, Zaitseva GV, Burdenny AM, Lukina SS, Loginov VI. Correlation of the polymorphic marker rs4072037 of the MUC1 gene with changes in the ocular surface in Sjögren’s syndrome. Oftal’mologiya. Vostochnaya Evropa. 2019;9(2):136-145. (In Russ.).
Safonova TN, Gladkova OV, Boev VI, Fedorov AA. Effectiveness of soft contact lenses in severe keratoconjunctivitis sicca treated with local immunosuppressive therapy. Vestnik oftal’mologii. 2016;132(5):39-48. (In Russ.). https://doi.org/10.17116/oftalma2016132539-48
Fedorov AA, Sherstneva LV. Clinical and cytological parallels with conjunctival inflammational diseases. Vestnik oftal’mologii. 1997;113(1):33-36. (In Russ.).
Fedorov AA. Morphological basics of scientific research in ophthalmology. Vestnik oftal’mologii. 2013;129(5):10-21. (In Russ.).
Safonova TN, Gladkova OV, Boev VI. Significance of laser confocal tomography in diagnosis and monitoring of keratoconjunctivitis sicca. Vestnik oftal’mologii. 2016;132(2):47-54. (In Russ., In Engl.). https://doi.org/10.17116/oftalma2016132247-54
Kintyukhina NP, Safonova TN, Gladkova OV. The use of laser scanning confocal microscopy of the eyelids for intraductal probing of the meibomian glands. Sovremennye tekhnologii v oftal’mologii. 2017;4:(112-114). (In Russ.).
Safonova TN, Sikach EI, Ozheredov IA. Current methods of tear film stability assessment. Vestnik oftal’mologii. 2019;135(5):92-98. (In Russ.). https://doi.org/10.17116/oftalma201913505192
Ozheredov I, Mischenko M, Prokopchuk M, Larichev A, Listopadskaya Y, Shkurinov A, Safonova T, Sikach E. Potential clinical applications of terahertz reflectometry for the assessment of the tear film stability. Optical Engineering. 2020;59:061622-061622. https://doi.org/10.1117/1.oe.59.6.061622
Kekkonen EA, Konovko AA, Li YuS, Li IM, Ozheredov IA, Park KH, Safonova TN, Sikach EI, Shkurinov AP. Assessment of the degree of hydration of the ocular surface tissues by terahertz reflectometry. Kvantovaya elektronika. 2020;50(1):61-68. (In Russ.). https://doi.org/10.1070/QEL17213
Safonova TN, Fedorov AA, Surnina ZV, Sikach EI, Ozheredov IA. Experimental investigation of the safety of terahertz radiation in corneal hydration assessment. Vestnik oftal’mologii. 2021;137(3):58-67. (In Russ.). https://doi.org/10.17116/oftalma202113703158
Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet. 2012;44(12):1336-1340. https://doi.org/10.1038/ng.24628
Ferro F, Vagelli R, Bruni C, Cafaro G, Marcucci., Bartoloni E, Baldini C. One year in review 2016: Sjögren’s syndrome. Clin Exp Rheumatol. 2016; 34(2):161-171.
Safonova TN, Zaitseva GV, Loginov VI, Burdenniy AM, Lukina SS. Association of polymorphisms of the TRIM21 gene with the severity of dry keratoconjunctivitis in rheumatoid arthritis and Sjögren’s disease. Vestnik oftal’mologii. 2019;135(5):192-198. (In Russ.). https://doi.org/10.17116/oftalma2019135052192
Safonova TN, Zaitseva GV. Molecular genetic examination for dry eye syndrome prognosis. Vestnik oftal’mologii. 2018;134(3):108-115. (In Russ.). https://doi.org/10.17116/oftalma20181343108
Safonova TN, Surnina ZV, Zaitseva GV, Burdennyi AM, Loginov VI. The Role of Polymorphic Markers rs1478604, rs2292305, and rs2228262 in THBS1 Gene in the Development of Autoimmune Dry Eye Syndrome. Bulletin of Experimental Biology and Medicine. 2020;169(5):707-709. (In Russ.). https://doi.org/10.1007/s10517-020-04960-0

Close metadata