Modern treatment methods for patients with liver metastases from uveal melanoma

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Uveal melanoma is a rare malignant neoplasm originating from the uveal tract of the eye. The liver is the most common site of metastasis, occurring in 70—90% of cases and becoming the sole site of metastasis in approximately 50% of observations. This literature review presents modern methods for treating liver metastases from uveal melanoma: immunotherapy, targeted therapy, oncolytic adenovirus therapy, chemoembolization, transarterial chemoembolization, drug-eluting bead therapy, immunoembolization, radioembolization, thermal ablation, isolated hepatic perfusion. The conclusion is drawn about the highest efficacy, safety, and availability of isolated hepatic perfusion compared to other treatment methods.

Keywords:

immunotherapy

targeted therapy

oncolytic adenovirus therapy

chemoembolization

transarterial chemoembolization

drug-eluting bead therapy

immunoembolization

radioembolization

thermal ablation

isolated hepatic perfusion

Authors:

V.M. Unguryan

Kostroma Oncology Dispensary

ORCID: 0000-0003-2094-0596

A.N. Kazantsev

Kostroma Regional Oncology Dispensary;
B.V. Petrovsky Russian Scientific Center of Surgery;
Kostroma Regional Clinical Hospital named after E.I. Korolev

ORCID: 0000-0002-1115-609X

A.M. Abduragimov

I.I. Mechnikov North-Western State Medical University

ORCID: 0009-0008-9851-5446

Yu.V. Belov

B.V. Petrovsky Russian Scientific Center of Surgery;
I.M. Sechenov First Moscow State Medical University

ORCID: 0000-0002-9280-8845

Received:

18.05.2023

Accepted:

26.07.2023

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