Sternal instability is the one of the unresolved problems in open cardiac surgery (1-8%). The risk of recurrence after repeated osteosynthesis is up to 20% in these patients. Repeated osteosynthesis is impossible in some cases, and this complicates anterior chest wall reconstruction. Among various methods of sternal reconstruction, there are options for repair with own tissues and various fixing devices. Mesh prostheses from titanium and its alloys are modern materials for chest defect closure. There are literature data on soft tissue structural changes after hernia repair with titanium mesh implants, but biological compatibility and advantages of titanium alloys for chest wall instability are unclear. We present 2 patients after sternal reconstruction with titanium mesh implant and subsequent partial removal of prosthesis for various reasons with morphological examination.