OBJECTIVE
To analyze the relationship between high and low NEOMOD scores, medical records, clinical characteristics and outcomes in preterm infants with gestational age <32 weeks and birth weight <1500 grams in early neonatal period.
MATERIAL AND METHODS
A retrospective observational cohort single-center study included 78 premature newborns between 2022 and 2023. All ones were divided into two groups: group 1 — low NEOMOD scores (2—4, n=58); group 2 — high NEOMOD scores (≥5, n=20). Inclusion criteria: birth in one perinatal center and immediate admission to ICU, birth weight <1500 grams, gestational age <32 weeks, multiple organ failure within 6 hours of life with NEOMOD score ≥2, dynamic assessment of scores until relief of multiple organ failure or death.
RESULTS
Higher NEOMOD scores were significantly more common in patients with low birth weight (980.0 vs 810.0, p=0.019), lower gestational age (28.0 weeks vs 25.0 weeks, p=0.008) and lower Apgar score at the 1st/5th minutes, respectively (5/6 vs 2.5/5.0, p=0.005/p=0.025). A full course of prenatal steroids avoids severe manifestations of multiple organ failure (46.6% vs 0.0%, p<0.001), and premature rupture of membranes increases the risk of multiple organ failure (17.2% vs 45.0%, p=0.018).
CONCLUSION
The modified NEOMOD score of multiple organ failure in infants with birth weight <1500 grams in early neonatal period increases with lower birth weight, height and gestational age, as well as in premature rupture of membranes. A full course of prenatal steroids has a protective effect against multiple organ failure. Polyuria in premature infants should be regarded as one of the manifestations of multiple organ failure.