Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
0 ₽
0 products
All journals
Journal
Year
Year
Search result: 0

Ia.O. Grusha

NII glaznykh bolezneĭ RAMN, Moskva

A.A. Fedorov

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

J.U. Prause

Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Frederik V’s Vej 11, 1., Copenhagen, Denmark, 2100

O.V. Éksarenko

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

V.A. Sheptulin

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

Experimental study of hyaluronic acid gel fillers biodegradation in orbit

Authors:

Ia.O. Grusha, A.A. Fedorov, J.U. Prause, O.V. Éksarenko, V.A. Sheptulin

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(2): 13‑19

DOI: 10.17116/oftalma202013602113

Views: 4804

Downloaded: 243

Download PDF (RU)
Download PDF
Contact the author
Table of contents

EXPERIMENTAL STUDY OF HYALURONIC ACID GEL FILLERS BIODEGRADATION IN ORBIT
EXPERIMENTAL STUDY OF HYALURONIC ACID GEL FILLERS BIODEGRADATION IN ORBIT

To cite this article:

Grusha IaO, Fedorov AA, Prause JU, Éksarenko OV, Sheptulin VA. Experimental study of hyaluronic acid gel fillers biodegradation in orbit. Russian Annals of Ophthalmology. 2020;136(2):13‑19. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202013602113

Здоровье щитовидной железы – 2024
Перекрестки терапевтических проблем
Доказательная гастроэнтерология: pro et contra
Актуальные вопросы педиатрической практики
Подписка 2024, 2 полугодие
NN - давайте знакомится (08.04.2024)
Использование инфографики авторами научных работ
МСФ на ЯМ
Mediasphera_Net
1med.tv
Close metadata
Recommended articles:
Fat grafting or hyaluronic acid inje­ctions: a map of indi­vidual indi­cations. Plastic Surgery and Aesthetic Medi­cine. 2023;(2):54-62
Phonophoresis with hyaluronic acid and laser technologies in correction of skin invo­lution. Plastic Surgery and Aesthetic Medi­cine. 2023;(2):63-66
Consensus on the algo­rithm of complex asse­ssment and correction of the lower third of the face. Plastic Surgery and Aesthetic Medi­cine. 2023;(3):93-109
Patient asse­ssment of effe­ctiveness of facial skin biorevitalization procedures: a prospective study. Plastic Surgery and Aesthetic Medi­cine. 2023;(4):93-100
Late complications after inje­ctable lips contour correction simu­lating an amelanotic mela­noma. Russian Journal of Clinical Dermatology and Vene­reology. 2023;(6):749-756
Study of facial muscles function after the chin treatment with hyaluronic acid filler. Plastic Surgery and Aesthetic Medi­cine. 2024;(1):84-95
Clinical study of effe­ctiveness and patients’ tole­rability profile of biorevitalization procedures course. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(2):199-205

Introduction. Recently, hyaluronic acid gel (HAG) fillers were proposed as an effective alternative treatment option for surgical orbital volume augmentation. Several authors reported about long-standing effect of the filler. Purpose — to assess the features of HAG biodegradation after intraorbital injection in experimental environment. Material and methods. In the course of the experiment, 7 chinchilla rabbits (14 eyes) received a single 1ml intraorbital HAG injection (Restylane SubQ, Galderma, Sweden) using a cannula. The animals’ orbits were examined by ultrasound scan after the injection and at 1, 3, 6, 9, 12 and 18 months. The animals were subsequently sacrificed for morphological study of orbital tissue containing the HAG filler. Results. The HAG filler persisted in the orbit of experimental animals during the whole follow-up period. The volume of HAG depot and its density diminished gradually till the 18th month, after which the particles of HAG could still be detected with the morphological study and ultrasound. Conclusion. The HAG filler persisted in the orbit of experimental animals up to 18 months. Incomplete biodegradation explains the longstanding duration of the injection effect.

Keywords:

injectable fillers
hyaluronic acid
intraorbital injection
neocollagenogenesis
rabbit

Authors:

Ia.O. Grusha

NII glaznykh bolezneĭ RAMN, Moskva

A.A. Fedorov

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

J.U. Prause

Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Frederik V’s Vej 11, 1., Copenhagen, Denmark, 2100

O.V. Éksarenko

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

V.A. Sheptulin

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

List of references:

  1. Matarasso SL, Carruthers JD, Jewell ML. Consensus recommendations for soft-tissue augmentation with nonanimal stabilized hyaluronic acid (Restylane). Plast Reconstr Surg. 2006;117(3):3-34. https://doi.org/10.1097/01.prs.0000204759.76865.39
  2. Comper WD, Laurent TC. Physiological function of connective tissue polysaccharides. Physiol Rev. 1978;58:255-315.
  3. Malhotra R. Deep orbital sub-Q Restylane (Nonanimal stabilized hyaluronic acid) for orbital volume enhancement in sighted and anophthalmic orbits. Arch Ophth. 2007;125:1623-1629. https://doi.org/10.1001/archopht.125.12.1623
  4. Tay E, Olver J. Intraorbital hyaluronic acid for enophthalmos. Ophthalmology. 2008;115:110-112. https://doi.org/10.1016/j.ophtha.2008.02.015
  5. Goldberg RA, Fiashetti D. Filling the orbital hollows with hyaluronic acid gel: initial experience with 244 injections. Ophthal Plast Reconstr Surg. 2006;22:335-341. https://doi.org/10.1097/01.iop.0000235820.00633.61
  6. Goldberg RA, Lee S, Jayasundera T, et al. Treatment of lower eyelid retraction by expansion of the lower eyelid with hyaluronic acid gel. Ophthal Plast Reconstr Surg. 2007;23:343-348. https://doi.org/10.1097/iop.0b013e318137aa41
  7. Taban M, Mancini R, Nakra T, et al. Nonsurgical management of congenital eyelid malpositions using hyaluronic Acid gel. Ophthal Plast Reconstr Surg. 2009;25(4):259-263. https://doi.org/10.1097/iop.0b013e3181ac984b
  8. Kataev MG. Use of Repleri hyaluronic acid injectable implant as a fuller and corrector of and periorbital region soft tissues defects in case of anophthalmos and eye presence. Prakticheskaya meditsina. Oftal’mologiya. 2012;04(12):194-198. (In Russ.).
  9. Grusha Y, Khovrin V, Stoyukhina A, Sheptulin V. Hyaluronic Acid Gel Re-Injection for Enophthalmos Correction in Silent Sinus Syndrome. Orbit. 2015;34(6):351-353. https://doi.org/10.3109/01676830.2015.1078376
  10. Feldman I, Sheptulin VA, Grusha YO, Malhotra R. Deep Orbital Sub-Q Hyaluronic Acid Filler Injection for Enophthalmic Sighted Eyes in Parry-Romberg Syndrome. Ophthalmic Plast Reconstr Surg. 2018;34(5):449-451. https://doi.org/10.1097/IOP.0000000000001050
  11. Grusha YO, Agafonova EI, Ismailova DS, Ivanchenko YuF. The first experience in using the stabilized hyaluronic acid preparation to correct lagophthalmos. Vestnik oftal’mologii. 2010;1:39-42. (In Russ.).
  12. Atamanov VV, Burilov KB. Sposob ustraneniya zapadeniya verkhnego veka pri anoftal’me. Patent RF na izobretenie №2342107/ 27.12.08. Accessed 28.01.19. (In Russ.). http://www.freepatent.ru/patents/2342107
  13. Kasparov AA, Gryaznova II, Vazhdi AS. Formation of locomotor stump after enucleation. Vestnik oftal’mologii. 1984;3:36-39. (In Russ.).
  14. Grusha YaO, Fedorov AA, Prause JU, Sheptulin VA. Histopathological study of experimental intrapalpebral injection of hyaluronic acid gel. Vestnik oftal’mologii. 2015;131(1):69-74. (In Russ.). https://doi.org/10.17116/oftalma2015131169-74
  15. Grusha YaO, Fedorov AA, Baranov PIu, Bakaeva TV, Pavliuk AS. Study of the three-dimensional structure and biointegrative characteristics of porous orbital implant materials. Vestnik oftal’mologii. 2010;126(5):9-13. (In Russ.).
  16. Gutierrez ML, Pe-Yan MR, Ortiz AC, Cruz JJ. Use of autologous-fat graft in postenucleation-socket syndrome. Philipp J Ophthalmol. 2009;34(2):70-73.
  17. Cakir B, Aygit AC, Omur-Okten O. Retro-orbital intraconal fat injection: an experimental study in rabbits. J Oral Maxillofac Surg. 2012;70(1):242-250. https://doi.org/10.1016/j.joms.2011.02.091
  18. Vagefi MR, McMullan TF, Burroughs JR, et al. Injectable calcium hydroxlapatite for orbital volume augmentation. Arch Facial Plast Surg. 2007;9:439-442. https://doi.org/10.1001/archfaci.9.6.439
  19. Carruthers J, Carruters A. Facial sculpting and tissue augmentation. Dermatol Surg. 2005;31:1604-1612. https://doi.org/10.2310/6350.2005.31248
  20. Crochelet O, Maalouf T, Duron S, Froussart F, Rigal-Sastourné JC, George JC. Efficacy and tolerability of highly crosslinked hyaluronic acid injections in the management of the enophthalmous orbit. Journal français d’ophtalmologie. 2012;35:441-447. https://doi.org/10.1016/j.jfo.2012.04.005
  21. Zamani M, Thyagarajan S, Olver JM. Adjunctive use of hyaluronic acid gel (Restylane Sub-Q) in anophthalmic volume deficient sockets and phthisical eyes. Ophthal Plast Reconstr Surg. 2010;26(4):250-253. https://doi.org/10.1097/iop.0b013e3181ba76f5
  22. Paap M, Milman T, Ugradar S, et al. Examining the Role of Retrobulbar Hyaluronidase in Reversing Filler-Induced Blindness: A Systematic Review. Ophthalmic Plast Reconstr Surg. 2019. [Epub ahead of print] https://doi.org/10.1097/IOP.0000000000001568
  23. Zhang LX, Lai LY, Zhou GW, et al. Evaluation of Intraarterial Thrombolysis in Treatment of Cosmetic Facial Filler-Related Ophthalmic Artery Occlusion. Plast Reconstr Surg. 2020;145(1):42-50. https://doi.org/10.1097/PRS.0000000000006313
  24. Grusha YO, Fedorov AA, Sheptulin VA. In’ektsionnye implantaty na osnove gelya gialuronovoi kisloty pri patologii pridatochnogo apparata glaza. M.: GEOTAR-Media; 2017. (In Russ.).

Close metadata

Contact the author
Email
Message

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.