Right-sided xenografts in children: analysis of dysfunction (in Russian only)

N.R. Nichay

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

Yu.Yu. Kulyabin

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

I.Iu. Zhuravleva

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Iu.N. Gorbatykh

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia Rossii

A.V. Zubritskiy

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

A.V. Voitov

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

I.A. Soynov

Meshalkin Novosibirsk National Medical Research Center of Healthcare Ministry of Russia, Novosibirsk, Russia, Federal Center for Cardiovascular Surgery of Healthcare Ministry of Russia, Perm, Russia, Topchibashov Research Center for Surgery of Healthcare Ministry of Azerbaijan, Baku, Azerbaijan

A.V. Gorbatykh

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

A.V. Bogachev-Prokof'ev

FGBU "Novosibirskiĭ NII patologii krovoobrashcheniia im. akad. E.N. Meshalkina" Minzdravsotsrazvitiia Rossii

A.M. Karas'kov

FGBU "Novosibirskiĭ NII patologii krovoobrashcheniia im. akad. E.N. Meshalkina" Minzdravsotsrazvitiia Rossii

Right-sided xenografts in children: analysis of dysfunction (in Russian only)

Authors:

N.R. Nichay, Yu.Yu. Kulyabin, I.Iu. Zhuravleva, Iu.N. Gorbatykh, A.V. Zubritskiy, A.V. Voitov, I.A. Soynov, A.V. Gorbatykh, A.V. Bogachev-Prokof'ev, A.M. Karas'kov

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(3): 173‑182

DOI: 10.17116/kardio201912031173

Downloaded: 12

To cite this article:

Nichay NR, Kulyabin YuYu, Zhuravleva IIu, Gorbatykh IuN, Zubritskiy AV, Voitov AV, Soynov IA, Gorbatykh AV, Bogachev-Prokof'ev AV, Karas'kov AM. Right-sided xenografts in children: analysis of dysfunction (in Russian only). Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(3):173‑182. (In Russ., In Engl.)
https://doi.org/10.17116/kardio201912031173

Доказательная гастроэнтерология: pro et contra

Актуальные вопросы педиатрической практики

Использование инфографики авторами научных работ

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Objective — to analyze the risk of redo surgery and causes of xenograft failure in children after right ventricular outflow tract (RVOT) repair with valved conduit. Material and methods. A retrospective analysis included patients under 18 years old who underwent RVOT repair with xenograft in 2000—2017. Results. Three hundreds and thirty-three patients underwent implantation of 373 xenografts including glutaraldehyde-crosslinked bovine jugular vein (GA-JV) (n=200, 53.6%), glutaraldehyde-crosslinked bovine pericardial valved conduit (GA-PC) (n=77, 20.6%), diepoxy-crosslinked porcine aortic root conduit (DE-AR) (n=58, 15.5%) and diepoxy-crosslinked bovine pericardial valved conduit (DE-PC) (n=38, 10.2%). The median follow-up was 4.2 years (range 2 month — 14.5 years). Multivariate regression analysis did not reveal significant correlation of redo surgery and type of xenograft (p=0.65). However, type of xenograft was significant risk factor for redo surgery due to xenograft calcification (p=0.007) and neointimal hyperplasia (p=0.01). DE-AR group had 3 times higher risk of calcification than GA-JV group (p<0.001). Risk of calcification in GA-PC and DE-PC groups was comparable with GA-JV group (p=0.24 and p=0.53, respectively). GA-PC group had significantly higher risk of neointimal proliferation and subsequent redo surgery in comparison with DE-PC group (p=0.006). Conclusion. Freedom from redo surgery did not differ between groups regardless type of xenograft. However, the causes of conduit failure were different. DE-PC conduits failed mostly due to calcification, while GA-treated xenografts failed due to obstruction as the result of neointimal hyperplasia.

Keywords:

congenital heart disease

pulmonary artery replacement

xenograft

calcification

neointimal proliferation

Authors:

N.R. Nichay

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

Yu.Yu. Kulyabin

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

I.Iu. Zhuravleva

Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ SO RAMN, Kemerovo

Iu.N. Gorbatykh

Novosibirskiĭ nauchno-issledovatel'skiĭ institut patologii krovoobrashcheniia im. akad. E.N. Meshalkina Minzdravsotsrazvitiia Rossii

A.V. Zubritskiy

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

A.V. Voitov

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

I.A. Soynov

A.V. Gorbatykh

Meshalkin National Medical Research Center, Ministry of Health of the Russia, Novosibirsk, Russia

A.V. Bogachev-Prokof'ev

FGBU "Novosibirskiĭ NII patologii krovoobrashcheniia im. akad. E.N. Meshalkina" Minzdravsotsrazvitiia Rossii

A.M. Karas'kov

FGBU "Novosibirskiĭ NII patologii krovoobrashcheniia im. akad. E.N. Meshalkina" Minzdravsotsrazvitiia Rossii

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