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V.A. Shaimova

S.M. Kirov Military Medical Academy;
Multidisciplinary Center for Laser Medicine;
Center Zreniya LLC

Yu.V. Nosul

Center Zreniya LLC;
Municipal Clinical Hospital No. 6

S.Kh. Kuchkildina

Center Zreniya LLC

A.N. Kulikov

S.M. Kirov Military Medical Academy

D.S. Maltsev

S.M. Kirov Military Medical Academy

T.B. Shaimov

Center Zreniya LLC

R.B. Shaimov

Center Zreniya LLC

E.S. Golovneva

Multidisciplinary Center of Laser Medicine;
South Ural State Medical University

T.G. Kravchenko

S.M. Kirov Military Medical Academy

A.Yu. Kholopova

Chelyabinsk Regional Pathoanatomical Bureau

V.V. Ermilov

Volgograd State Medical University

R.B. Berdnikov

Ural State Medical University;
Ural Scientific Research Institute of Phthisiopulmonology — branch of National Research Medical Center of Phthisiopulmonology and Infectious Diseases

Retrolental amyloidosis of the vitreous body (case study)

Authors:

V.A. Shaimova, Yu.V. Nosul, S.Kh. Kuchkildina, A.N. Kulikov, D.S. Maltsev, T.B. Shaimov, R.B. Shaimov, E.S. Golovneva, T.G. Kravchenko, A.Yu. Kholopova, V.V. Ermilov, R.B. Berdnikov

More about the authors

Journal: Vestnik Oftalmologii. 2021;137(4): 98‑103

DOI: 10.17116/oftalma202113704198

Views: 1188

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To cite this article:

Shaimova VA, Nosul YuV, Kuchkildina SKh, Kulikov AN, Maltsev DS, Shaimov TB, Shaimov RB, Golovneva ES, Kravchenko TG, Kholopova AYu, Ermilov VV, Berdnikov RB. Retrolental amyloidosis of the vitreous body (case study). Vestnik Oftalmologii. 2021;137(4):98‑103. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202113704198

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Accumulations of pathological amyloid protein in the vitreous can be a pathognomonic morphological sign of systemic amyloidosis, which is characterized by deposition of insoluble fibrillar protein aggregates (amyloid) in various organs and tissues. The article describes a clinical case of a female 65-year-old patient with bilateral vitreous floaters and histologically confirmed vitreous amyloidosis on the right eye. The patient had undergone YAG laser vitreolysis of the right eye 3 years ago on the Ultra Q Reflex system («Ellex», Australia) to treat an atypical Weiss ring. Diagnosis of vitreous amyloidosis was confirmed using the following equipment: video slit lamp SL9900 («CSO», Italy), optical coherence tomography system Solix («Optovue», USA), B-scan Plus («Accutome», USA), microscope CX41RF («Olympus Corporation», Japan). Due to significant visual deterioration in the right eye, the patient underwent vitrectomy. Microscopic examination of the surgical sample showed the presence of amyloid deposits revealed by the brick-red specific staining with congo red dye and apple-green birefringence of the stained areas in polarized light.

Keywords:

vitreous floaters
vitreous amyloidosis
YAG laser vitreolysis

Authors:

V.A. Shaimova

S.M. Kirov Military Medical Academy;
Multidisciplinary Center for Laser Medicine;
Center Zreniya LLC

Yu.V. Nosul

Center Zreniya LLC;
Municipal Clinical Hospital No. 6

S.Kh. Kuchkildina

Center Zreniya LLC

A.N. Kulikov

S.M. Kirov Military Medical Academy

D.S. Maltsev

S.M. Kirov Military Medical Academy

T.B. Shaimov

Center Zreniya LLC

R.B. Shaimov

Center Zreniya LLC

E.S. Golovneva

Multidisciplinary Center of Laser Medicine;
South Ural State Medical University

T.G. Kravchenko

S.M. Kirov Military Medical Academy

A.Yu. Kholopova

Chelyabinsk Regional Pathoanatomical Bureau

V.V. Ermilov

Volgograd State Medical University

R.B. Berdnikov

Ural State Medical University;
Ural Scientific Research Institute of Phthisiopulmonology — branch of National Research Medical Center of Phthisiopulmonology and Infectious Diseases

Received:

09.07.2021

Accepted:

17.07.2021

List of references:

  1. Milston R, Madigan MC, Sebag J. Vitreous floaters: etiology, diagnostics, and management. Surv Ophthalmol. 2016;61(2):211-227.  https://doi.org/10.1016/j.survophthal.2015.11.008
  2. Shaimova VA, Shaimov TB, Shaimov RB, Galin AYu, Goloshchapova ZhA, Ryzhkov PK, Fomin AV. Evaluation of YAG-laser vitreolysis effectiveness based on quantitative characterization of vitreous floaters. Vestnik oftal’mologii. 2018;134(1):56-62 (In Russ.). https://doi.org/10.17116/oftalma2018134156-62
  3. Schmitz-Valckenberg S, Brasse K, Hoerauf H. Degenerative Glaskörpertrübungen [Vitreous floaters]. Ophthalmologe. 2020;117(5):485-496. (In Germ.). https://doi.org/10.1007/s00347-020-01094-6
  4. Ferreira N. Ophtalmologic changes in transthyretin familial amyloid polyneuropathy (ATTR-FAP). Orphanet J Rare Dis. 2015;10(suppl 1):19.  https://doi.org/10.1186/1750-1172-10-S1-I9
  5. Seca M, Ferreira N, Coelho T. Vitreous Amyloidosis as the Presenting Symptom of Familial Amyloid Polyneuropathy TTR Val30Met in a Portuguese Patient. Case Rep Ophthalmol. 2014;5(1):92-97.  https://doi.org/10.1159/000360790
  6. Coppock JD, Dusenbery AC, Elghawy O, Fellenstein LA, Frierson HF Jr, Shildkrot Y. Cytodiagnosis and protein typing of amyloid from a vitreous washing: initial diagnostic workup of hereditary amyloidosis. J Am Soc Cytopathol. 2020;9(3):173-176.  https://doi.org/10.1016/j.jasc.2020.01.003
  7. Dammacco R, Merlini G, Lisch W, Kivelä, TT, Giancipoli E, Vacca A, Dammacco F. Amyloidosis and Ocular Involvement: an Overview. Semin Ophthalmol. 2020;35(1):7-26.  https://doi.org/10.1080/08820538.2019.1687738
  8. Das S, Tiple S, Pegu J, Dubey S, Mathur U, Mulay K, Shields CL. Intraocular amyloidosis with multifocal iris and anterior chamber translucent spherules. Indian J Ophthalmol. 2019;67(12):2078-2080. https://doi.org/10.4103/ijo.IJO_812_19
  9. Kang S, Dehabadi MH, Rose GE, Verity DH, Amin S, Das-Bhaumik R. Ocular amyloid: adnexal and systemic involvement. Orbit. 2020;39(1):13-17.  https://doi.org/10.1080/01676830.2019.1594988
  10. Shukla S, Cohen A, Josephberg RG. Nonfamilial vitreous amyloidosis diagnosed by portable sutureless vitrectomy. Retin Cases Brief Rep. 2008;2(4):264-265.  https://doi.org/10.1097/ICB.0b013e318074c2e7
  11. Venkatesh P, Selvan H, Singh SB, Gupta D, Kashyap S, Temkar S, Gogia V, Tripathy K, Chawla R, Vohra R. Vitreous Amyloidosis: Ocular, Systemic, and Genetic Insights. Ophthalmology. 2017;124(7):1014-1022. https://doi.org/10.1016/j.ophtha.2017.03.011
  12. Koga T, Ando E, Hirata A, Fukushima M, Kimura A, Ando Y, Negi A, Tanihara H. Vitreous opacities and outcome of vitreous surgery in patients with familial amyloidotic polyneuropathy. Am J Ophthalmol. 2003;135(2):188-193.  https://doi.org/10.1016/s0002-9394(02)01838-x
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