Современные возможности диагностики и лечения эндофтальмитов

Закрыть метаданные

Эндофтальмит характеризуется воспалением внутриглазных жидкостей и тканей, которое может привести к необратимой потере зрения, если не лечить данное заболевание своевременно и должным образом. Эндофтальмит классифицируют на экзогенный и эндогенный в зависимости от пути передачи инфекционного агента. Экзогенный эндофтальмит возникает, если патогены попадают в глаз посредством прямой инокуляции, тогда как эндогенный эндофтальмит развивается, если инфекционные агенты распространяются в глаз гематогенным путем из отдаленного очага инфекции. Классификация эндофтальмита позволяет определить этиологию и вероятных возбудителей заболевания. Диагностика эндофтальмита основывается на клинических данных. Ранняя диагностика и правильное лечение являются ключом к спасению глаза. Для достижения наилучших результатов необходимо быстрое начало эмпирической антимикробной терапии широкого спектра.

Ключевые слова:

эндофтальмит

Авторы:

Халатян А.С.

ФГБНУ «Научно-исследовательский институт глазных болезней»

Даты поступления:

31.05.2020

Даты принятия в печать:

08.06.2020

Список литературы:

Vaziri K, Schwartz SG, Kishor K, Flynn HW Jr. Endophthalmitis: state of art. Clinical Ophthalmology. 2015;9:95-108. https://doi.org/10.2147/opth.s76406
Verbraeken H. Treatment of postoperative endophthalmitis. Ophthalmologica. 1995;209(3):165-171. https://doi.org/10.1159/000310605
Alharbi SS, Alrajhi A, Alkahtani E. Endophthalmitis following keratoplasty: incidence, microbial profile, visual and structural outcomes. Ocular Immunology and Inflammation. 2014;22(3):218-223. https://doi.org/10.3109/09273948.2013.841956
Tay E, Bainbridge J, da Cruz L. Subretinal abscess after scleral buckling surgery: a rare risk of retinal surgery. Canadian Journal of Ophthalmology. 2007; 42(1):141-142. https://doi.org/10.3129/canjophthalmol.06-110
ESCRS Endophthalmitis Study Group. Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors. Journal of Cataract and Refractive Surgery. 2007;33(6):978-988. https://doi.org/10.1016/j.jcrs.2007.02.032
Park JC, Ramasamy B, Shaw S, Ling RH, Prasad S. A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: clinical presentation, microbiology, management and outcome. British Journal of Ophthalmology. 2014;98(8):1080-1086. https://doi.org/10.1136/bjophthalmol-2013-304486
Schwartz SG, Flynn HW Jr, Das T, Mieler WF. Ocular infection: endophthalmitis. Developments in Ophthalmology. 2016;55:176-188. https://doi.org/10.1159/000431195
Hatch WV, Cernat G, Wong D, Devenyi R, Bell CM. Risk factors for acute endophthalmitis after cataract surgery: a population-based study. Ophthalmology. 2009;116(3):425-430. https://doi.org/10.1016/j.ophtha.2008.09.039
Shirodkar AR, Pathengay A, Flynn HW Jr, Albini TA, Berrocal AM, Davis JL, Lalwani GA, Murray TG, Smiddy WE, Miller D. Delayed- versus acute-onset endophthalmitis after cataract surgery. American Journal of Ophthalmology. 2012;153(3):391-398.e2. https://doi.org/10.1016/j.ajo.2011.08.029
Wykoff CC, Parrott MB, Flynn HW Jr, Shi W, Miller D, Alfonso EC. Nosocomial acute-onset postoperative endophthalmitis at a University Teaching Hospital (2002—2009). American Journal of Ophthalmology. 2010;150(3): 392-398.e2. https://doi.org/10.1016/j.ajo.2010.04.010
Fox GM, Joondeph BC, Flynn HW Jr, Pflugfelder SC, Roussel TJ. Delayed-onset pseudophakic endophthalmitis. American Journal of Ophthalmology. 1991;111(2):163-173. https://doi.org/10.1016/s0002-9394(14)72254-8
Brillat-Zaratzian E, Bron A, Aptel F, Romanet JP, Cornut PL, Vandenesch F, Boisset S, Maurin M, Chiquet C. FRIENDS Group: clinical and microbiological characteristics of post-filtering surgery endophthalmitis. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2014;252(1):101-107. https://doi.org/10.1007/s00417-013-2503-4
Ciulla TA, Beck AD, Topping TM, Baker AS. Blebitis, early endophthalmitis, and late endophthalmitis after glaucoma-filtering surgery. Ophthalmology. 1997;104(6):986-995. https://doi.org/10.1016/s0161-6420(97)30196-1
Ashkenazi I, Melamed S, Avni I, Bartov E, Blumenthal M. Risk factors associated with late infection of filtering blebs and endophthalmitis. Ophthalmic Surgery. 1991;22(10):570-574.
Solomon A, Ticho U, Frucht-Pery J. Late-onset, bleb-associated endophthalmitis following glaucoma filtering surgery with or without antifibrotic agents. Journal of Ocular Pharmacology and Therapeutics. 1999;15(4): 283-293. https://doi.org/10.1089/jop.1999.15.283
Prasad N, Latina MA. Blebitis and endophthalmitis after glaucoma filtering surgery. International Ophthalmology Clinics. 2007;47(2):85-97. https://doi.org/10.1097/iio.0b013e31803775c6
Fileta JB, Scott IU, Flynn HW Jr. Meta-analysis of infectious endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. Ophthalmic Surgery, Lasers and Imaging Retina. 2014;45(2):143-149. https://doi.org/10.3928/23258160-20140306-08
Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY; MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. New England Journal of Medicine. 2006;355(14):1419-1431. https://doi.org/10.1056/nejmoa054481
Irigoyen C, Ziahosseini K, Morphis G, Stappler T, Heimann H. Endophthalmitis following intravitreal injections. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2012;250(4):499-505. https://doi.org/10.1007/s00417-011-1851-1
McCannel CA. Meta-analysis of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents: causative organisms and possible prevention strategies. Retina. 2011;31(4):654-661. https://doi.org/10.1097/iae.0b013e31820a67e4
Artunay O, Yuzbasioglu E, Rasier R, Sengül A, Bahcecioglu H. Incidence and management of acute endophthalmitis after intravitreal bevacizumab (Avastin) injection. Eye (London). 2009;23(12):2187-2193. https://doi.org/10.1038/eye.2009.7
Roth DB, Flynn HW Jr. Distinguishing between infectious and noninfectious endophthalmitis after intravitreal triamcinolone injection. American Journal of Ophthalmology. 2008;146(3):346-347. https://doi.org/10.1016/j.ajo.2008.04.037
Goldberg RA, Shah CP, Wiegand TW, Heier JS. Noninfectious inflammation after intravitreal injection of aflibercept: clinical characteristics and visual outcomes. American Journal of Ophthalmology. 2014;158(4):733-737. https://doi.org/10.1016/j.ajo.2014.06.019
Chong DY, Anand R, Williams PD, Qureshi JA, Callanan DG. Characterization of sterile intraocular inflammatory responses after intravitreal bevacizumab injection. Retina. 2010;30(9):1432-1440. https://doi.org/10.1097/iae.0b013e3181dc04da
Sakamoto T, Ishibashi T, Ogura Y, Shiraga F, Takeuchi S, Yamashita H; Japanese Retina and Vitreous Society Triamcinolone Survey Group. Survey of triamcinolone-related non-infectious endophthalmitis. Nihon Ganka Gakkai Zasshi. 2011;115(6):523-528.
Fan JC, Niederer RL, von Lany H, Polkinghorne PJ. Infectious endophthalmitis: clinical features, management and visual outcomes. Clinical and Experimental Ophthalmology. 2008;36(7):631-636. https://doi.org/10.1111/j.1442-9071.2008.01813.x
Zhang Y, Zhang MN, Jiang CH, Yao Y, Zhang K. Endophthalmitis following open globe injury. British Journal of Ophthalmology. 2010;94(1):111-111. https://doi.org/10.1136/bjo.2009.164913
Reynolds DS, Flynn HW Jr. Endophthalmitis after penetrating ocular trauma. Current Opinion in Ophthalmology. 1997;8(3):32-38. https://doi.org/10.1097/00055735-199706000-00006
Nicoară SD, Irimescu I, Călinici T, Cristian C. Outcome and prognostic factors for traumatic endophthalmitis over a 5-year period. Journal of Ophthalmology. 2014;747015. https://doi.org/10.1155/2014/747015
Long C, Liu B, Xu C, Jing Y, Yuan Z, Lin X. Causative organisms of post-traumatic endophthalmitis: a 20-year retrospective study. Ophthalmology. 2014;14:34. https://doi.org/10.1186/1471-2415-14-34
Jindal A, Pathengay A, Mithal K, Jalali S, Mathai A, Pappuru RR, Narayanan R, Chhablani J, Motukupally SR, Sharma S, Das T, Flynn HW Jr. Endophthalmitis after open globe injuries: changes in microbiological spectrum and isolate susceptibility patterns over 14 years. Journal of Ophthalmic Inflammation and Infection. 2014;4(1):5. https://doi.org/10.1186/1869-5760-4-5
Ahmed Y, Schimel AM, Pathengay A, Colyer MH, Flynn HW Jr. Endophthalmitis following open-globe injuries. Eye (London). 2012;26(2):212-217.
Chee SP, Jap A. Endogenous endophthalmitis. Current Opinion in Ophthalmology. 2001;12:464-470. https://doi.org/10.1038/eye.2011.313
Sheu SJ. Endophthalmitis. Korean Journal of Ophthalmology. 2017;31(4): 283-289. https://doi.org/10.3341/kjo.2017.0036
Shrader SK, Band JD, Lauter CB, Murphy P. The clinical spectrum of endophthalmitis: incidence, predisposing factors, and features influencing outcome. Journal of Infectious Diseases. 1990;162(1):115-120. https://doi.org/10.1093/infdis/162.1.115
Jackson TL, Paraskevopoulos T, Georgalas I. Systematic review of 342 cases of endogenous bacterial endophthalmitis. Survey of Ophthalmology. 2014; 59(6):627-635. https://doi.org/10.1016/j.survophthal.2014.06.002
Adam MK, Vahedi S, Nichols MM, Fintelmann RE, Keenan JD, Garg SJ, Hsu J, Maguire JI, Spirn MJ. Inpatient ophthalmology consultation for fungemia: prevalence of ocular involvement and necessity of funduscopic screening. American Journal of Ophthalmology. 2015;160(5):1078-1083.e2. https://doi.org/10.1016/j.ajo.2015.07.033
Sheu SJ, Kung YH, Wu TT, Chang FP, Horng YH. Risk factors for endogenous endophthalmitis secondary to klebsiella pneumoniae liver abscess: 20-year experience in Southern Taiwan. Retina. 2011;31(10):2026-2031. https://doi.org/10.1097/iae.0b013e31820d3f9e
Aziz HA, Berrocal AM, Sisk RA, Hartley K, Diaz-Barbosa M, Johnson RA, Hess D, Dubovy SR, Murray TG, Flynn HW Jr. Intraocular infections in the neonatal intensive care unit. Clinical Ophthalmology. 2012;6:733-737. https://doi.org/10.2147/opth.s26362
Ness T, Pelz K, Hansen LL. Endogenous endophthalmitis: microorganisms, disposition and prognosis. Acta Ophthalmologica Scandinavica. 2007;85(8): 852-856. https://doi.org/10.1111/j.1600-0420.2007.00982.x
Chen SC, Lee YY, Chen YH, Lin HS, Wu TT, Sheu SJ. Klebsiella pneumoniae infection leads to a poor visual outcome in endogenous endophthalmitis: a 12-year experience in Southern Taiwan. Ocular Immunology and Inflammation. 2016;20(6):870-877. https://doi.org/10.1080/09273948.2016.1193616
Mowat A, Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. New England Journal of Medicine. 1971;284(12): 621-627. https://doi.org/10.1056/nejm197103252841201
Tsai CC, Chen SJ, Chung YM, Yu KW, Hsu WM. Postpartum endogenous Candida endophthalmitis. Journal of the Formosan Medical Association. 2002; 101(6):432-436.
Li AL, Wykoff CC, Wang R, Chen E, Benz MS, Fish RH, Wong TP, Major JC Jr, Brown DM, Schefler AC, Kim RY, OʼMalley RE. Endophthalmitis after intravitreal injection: role of prophylactic topical ophthalmic antibiotics. Retina. 2016;36(7):1349-1356. https://doi.org/10.1097/iae.0000000000000901
Torres-Costa S, Ramos D, Brandao E, Carneiro Â, Rosas V, Rocha-Sousa A, Falcão-Reis F, Falcão M. Incidence of endophthalmitis after intravitreal injection with and without topical antibiotic prophylaxis. European Journal of Ophthalmology. 2020:1120672120902028. Online ahead of print. https://doi.org/10.1177/1120672120902028
Werner L, Sher JH, Taylor JR, Mamalis N, Nash WA, Csordas JE, Green G, Maziarz EP, Liu XM. Toxic anterior segment syndrome and possible association with ointment in the anterior chamber following cataract surgery. Journal of Cataract and Refractive Surgery. 2006;32(2):227-235. https://doi.org/10.1016/j.jcrs.2005.12.093
Eser I, Kapran Z, Altan T, Eren H, Yilmaz OF. The use of blood culture bottles in endophthalmitis. Retina. 2007;27(7):971-973. https://doi.org/10.1097/iae.0b013e31802bfe04
Lott MN, Fuller JJ, Hancock HA, Singh J, Singh H, McGwin G Jr, Marcus DM. Vitreal penetration of oral moxifloxacin in humans. Retina. 2008; 28(3):473-476. https://doi.org/10.1097/iae.0b013e31814fb0ed
Hooper CY, Lightman SL, Pacheco P, Tam PM, Khan A, Taylor SR. Adjunctive antibiotics in the treatment of acute bacterial endophthalmitis following cataract surgery. Acta Ophthalmologica. 2012;90(7):572-573. https://doi.org/10.1111/j.1755-3768.2011.02365.x
Das T. Endophthalmitis Management: Stain-Culture, Empirical Treatment, and Beyond. Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.). 2020; 9(1):1-3. https://doi.org/10.1097/01.apo.0000617904.11979.ae
Dave TV, Dave VP, Sharma S, Karolia R, Joseph J, Pathengay A, Pappuru RR, Das T. Infectious endophthalmitis leading to evisceration: spectrum of bacterial and fungal pathogens and antibacterial susceptibility profile. Journal of Ophthalmic Inflammation and Infection. 2019;9(1):9. https://doi.org/10.1186/s12348-019-0174
Menchini F, Toneatto G, Miele A, Donati S, Lanzetta P, Virgili G. Antibiotic prophylaxis for preventing endophthalmitis after intravitreal injection: a systematic review. Eye (London). 2018;32(9):1423-1431. https://doi.org/10.1038/s41433-018-0138-8
Kim SJ, Toma HS. Antimicrobial resistance and ophthalmic antibiotics: 1-year results of a longitudinal controlled study of patients undergoing intravitreal injections. Archives of Ophthalmology. 2011;129(9):1180-1188. https://doi.org/10.1001/archophthalmol.2011.213
Фролычев И.А., Поздеева Н.А. Послеоперационный эндофтальмит. Обзор литературы. Практическая медицина. 2017;9(110):192-195. https://doi.org/10.25276/0235-4160-2018-1-66-71

Закрыть метаданные