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Ia.O. Grusha

NII glaznykh bolezneĭ RAMN, Moskva

A.A. Fedorov

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

J.U. Prause

Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Frederik V’s Vej 11, 1., Copenhagen, Denmark, 2100

O.V. Éksarenko

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

V.A. Sheptulin

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

Experimental study of hyaluronic acid gel fillers biodegradation in orbit

Authors:

Ia.O. Grusha, A.A. Fedorov, J.U. Prause, O.V. Éksarenko, V.A. Sheptulin

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(2): 13‑19

DOI: 10.17116/oftalma202013602113

Views: 4679

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Table of contents

EXPERIMENTAL STUDY OF HYALURONIC ACID GEL FILLERS BIODEGRADATION IN ORBIT
EXPERIMENTAL STUDY OF HYALURONIC ACID GEL FILLERS BIODEGRADATION IN ORBIT

To cite this article:

Grusha IaO, Fedorov AA, Prause JU, Éksarenko OV, Sheptulin VA. Experimental study of hyaluronic acid gel fillers biodegradation in orbit. Russian Annals of Ophthalmology. 2020;136(2):13‑19. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202013602113

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Introduction. Recently, hyaluronic acid gel (HAG) fillers were proposed as an effective alternative treatment option for surgical orbital volume augmentation. Several authors reported about long-standing effect of the filler. Purpose — to assess the features of HAG biodegradation after intraorbital injection in experimental environment. Material and methods. In the course of the experiment, 7 chinchilla rabbits (14 eyes) received a single 1ml intraorbital HAG injection (Restylane SubQ, Galderma, Sweden) using a cannula. The animals’ orbits were examined by ultrasound scan after the injection and at 1, 3, 6, 9, 12 and 18 months. The animals were subsequently sacrificed for morphological study of orbital tissue containing the HAG filler. Results. The HAG filler persisted in the orbit of experimental animals during the whole follow-up period. The volume of HAG depot and its density diminished gradually till the 18th month, after which the particles of HAG could still be detected with the morphological study and ultrasound. Conclusion. The HAG filler persisted in the orbit of experimental animals up to 18 months. Incomplete biodegradation explains the longstanding duration of the injection effect.

Keywords:

injectable fillers
hyaluronic acid
intraorbital injection
neocollagenogenesis
rabbit

Authors:

Ia.O. Grusha

NII glaznykh bolezneĭ RAMN, Moskva

A.A. Fedorov

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

J.U. Prause

Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Frederik V’s Vej 11, 1., Copenhagen, Denmark, 2100

O.V. Éksarenko

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

V.A. Sheptulin

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

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